1kn4

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[[Image:1kn4.gif|left|200px]]
[[Image:1kn4.gif|left|200px]]
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{{Structure
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|PDB= 1kn4 |SIZE=350|CAPTION= <scene name='initialview01'>1kn4</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_1kn4", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=PDE:PARA-NITROPHENYL+PHOSPHONOBUTANOYL+D-ALANINE'>PDE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_1kn4| PDB=1kn4 | SCENE= }}
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|RELATEDENTRY=[[1yec|1YEC]], [[1yef|1YEF]], [[1yeg|1YEG]], [[1yeh|1YEH]], [[1yei|1YEI]], [[1yej|1YEJ]], [[1yek|1YEK]], [[1kn2|1KN2]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kn4 OCA], [http://www.ebi.ac.uk/pdbsum/1kn4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kn4 RCSB]</span>
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'''CATALYTIC ANTIBODY D2.3 COMPLEX'''
'''CATALYTIC ANTIBODY D2.3 COMPLEX'''
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[[Category: Gigant, B.]]
[[Category: Gigant, B.]]
[[Category: Knossow, M.]]
[[Category: Knossow, M.]]
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[[Category: abzyme]]
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[[Category: Abzyme]]
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[[Category: immune system]]
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[[Category: Immune system]]
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[[Category: transition state analog]]
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[[Category: Transition state analog]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 22:56:16 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:50:49 2008''
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Revision as of 19:56, 2 May 2008

Image:1kn4.gif

Template:STRUCTURE 1kn4

CATALYTIC ANTIBODY D2.3 COMPLEX


Overview

The crystal structures of catalytic antibody D2.3 Fab with the two enantiomers, 7D and 7L, which represent transition state analogues for the hydrolysis of the corresponding esters, 6D and 6L, were determined to better understand remarkable reactivity differences: the L-ester displayed significantly tighter binding (K(M)) and increased catalytic activity (k(cat)) with D2.3, even though the chiral center is 7 bonds distant from the reaction center. Surprisingly, the electron densities of the liganded phosphonates, 7D and 7L, within the D2.3 binding/reaction site were essentially identical, highlighting the subtle influences of protein interactions on chemical behavior.

About this Structure

1KN4 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Remarkable remote chiral recognition in a reaction mediated by a catalytic antibody., D'Souza LJ, Gigant B, Knossow M, Green BS, J Am Chem Soc. 2002 Mar 13;124(10):2114-5. PMID:11878955 Page seeded by OCA on Fri May 2 22:56:16 2008

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