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4y2b

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<StructureSection load='4y2b' size='340' side='right'caption='[[4y2b]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4y2b' size='340' side='right'caption='[[4y2b]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4y2b]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y2B FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4y2b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y2B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y2B FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPK:3-ETHYL-2-(PROPAN-2-YLAMINO)-7-(PYRIDIN-3-YL)THIENO[3,2-D]PYRIMIDIN-4(3H)-ONE'>EPK</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPK:3-ETHYL-2-(PROPAN-2-YLAMINO)-7-(PYRIDIN-3-YL)THIENO[3,2-D]PYRIMIDIN-4(3H)-ONE'>EPK</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PDE7A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y2b OCA], [https://pdbe.org/4y2b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y2b RCSB], [https://www.ebi.ac.uk/pdbsum/4y2b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y2b ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-AMP_phosphodiesterase 3',5'-cyclic-AMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.53 3.1.4.53] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y2b OCA], [http://pdbe.org/4y2b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4y2b RCSB], [http://www.ebi.ac.uk/pdbsum/4y2b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4y2b ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDE7A_HUMAN PDE7A_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.<ref>PMID:19350606</ref>
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[https://www.uniprot.org/uniprot/PDE7A_HUMAN PDE7A_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.<ref>PMID:19350606</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Phosphodiesterase|Phosphodiesterase]]
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 3',5'-cyclic-AMP phosphodiesterase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Amano, S]]
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[[Category: Amano S]]
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[[Category: Asano, T]]
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[[Category: Asano T]]
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[[Category: Asanuma, Y]]
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[[Category: Asanuma Y]]
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[[Category: Endo, Y]]
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[[Category: Endo Y]]
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[[Category: Irie, T]]
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[[Category: Irie T]]
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[[Category: Kamei, N]]
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[[Category: Kamei N]]
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[[Category: Kawai, K]]
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[[Category: Kawai K]]
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[[Category: Onodera, Y]]
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[[Category: Onodera Y]]
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[[Category: Sawada, K]]
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[[Category: Sawada K]]
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[[Category: Sonoda, Y]]
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[[Category: Sonoda Y]]
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[[Category: Takahashi, N]]
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[[Category: Takahashi N]]
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[[Category: Ueo, N]]
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[[Category: Ueo N]]
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[[Category: Camp]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Pde7a]]
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[[Category: Phosphodiesterase]]
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Revision as of 18:03, 26 April 2023

Co-crystal structure of 3-ethyl-2-(isopropylamino)-7-(pyridin-3-yl)thieno[3,2-d]pyrimidin-4(3H)-one bound to PDE7A

PDB ID 4y2b

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