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Gyrase 3D Structures

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(New page: ==3D Structure of Gyrase== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *Gyrase Subunit A **3l6v – GyrA C...)
Current revision (09:41, 27 April 2023) (edit) (undo)
 
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
-
*Gyrase Subunit A
+
*Gyrase Subunit A; Domains – N-terminal 1-523; C-terminal 535-841
**[[3l6v]] – GyrA C-terminal – ''Xanthomonas campestris'' <br />
**[[3l6v]] – GyrA C-terminal – ''Xanthomonas campestris'' <br />
-
**[[2y3p]], [[4ckl]] – EcGyrA N-terminal+simocylinone – ''Escherichia coli''<br />
+
**[[1ajb]], [[2y3p]], [[4ckl]] – EcGyrA N-terminal + drug – ''Escherichia coli''<br />
-
**[[1ajb]] - EcGyrA N-terminal+novobiocin<br />
+
**[[4ckk]] - EcGyrA N-terminal<br />
**[[4ckk]] - EcGyrA N-terminal<br />
**[[1zi0]], [[1ab4]] - EcGyrA C-terminal<br />
**[[1zi0]], [[1ab4]] - EcGyrA C-terminal<br />
**[[1x75]] – EcGyrA14+CcdB<br />
**[[1x75]] – EcGyrA14+CcdB<br />
**[[4elz]] - GyrA fragment+CcdB – ''Vibrio fischeri''<br />
**[[4elz]] - GyrA fragment+CcdB – ''Vibrio fischeri''<br />
-
**[[3ilw]], [[3ifz]] - MtGyrA ATPase domain – ''Mycobacterium tuberculosis''<br />
+
**[[3ilw]], [[3ifz]] - MtGyrA N-terminal – ''Mycobacterium tuberculosis''<br />
**[[3uc1]], [[4g3n]] - MtGyrA C-terminal<br />
**[[3uc1]], [[4g3n]] - MtGyrA C-terminal<br />
**[[1suu]] - GyrA C-terminal – ''Borrelia burgdorferi''<br />
**[[1suu]] - GyrA C-terminal – ''Borrelia burgdorferi''<br />
Line 19: Line 18:
**[[3lpx]] – GyrA N-terminal – ''Colwellia psychrerithraea''<br />
**[[3lpx]] – GyrA N-terminal – ''Colwellia psychrerithraea''<br />
**[[4ely]] – GyrA residues 363-497 + CcdB – ''Shigella flexneri''<br />
**[[4ely]] – GyrA residues 363-497 + CcdB – ''Shigella flexneri''<br />
-
**[[4ddq]] – GyrA – ''Bacillus subtilis''<br />
+
**[[4ddq]] – GyrA N-terminal – ''Bacillus subtilis''<br />
**[[6n1r]], [[6n1q]] – SpGyrA N-terminal – ''Streptococcus pneumoniae'' – Cryo EM<br />
**[[6n1r]], [[6n1q]] – SpGyrA N-terminal – ''Streptococcus pneumoniae'' – Cryo EM<br />
**[[6n1p]] – SpGyrA N-terminal + DNA – Cryo EM<br />
**[[6n1p]] – SpGyrA N-terminal + DNA – Cryo EM<br />
**[[5ztj]] - SeGyrA C-terminal – ''Salmonella enterica''<br />
**[[5ztj]] - SeGyrA C-terminal – ''Salmonella enterica''<br />
-
*Gyrase Subunit B
+
*Gyrase Subunit B; Domains – ATPase or N-terminal 1-220; C-terminal 448-675
-
**[[3g75]], [[3g7b]], [[3g7e]], [[3ttz]], [[3u2d]], [[3u2k]], [[4p8o]], [[5cph]], [[5ctu]], [[5ctw]], [[5ctx]], [[5cty]] – GyrB N-terminal residues 2-234 + inhibitor – ''Staphylococcus aureus''<br />
+
**[[3g75]], [[3g7b]], [[3g7e]], [[3ttz]], [[3u2d]], [[3u2k]], [[4p8o]], [[5cph]], [[5ctu]], [[5ctw]], [[5ctx]], [[5cty]], [[6tck]], [[6ttg]] – GyrB N-terminal residues 2-234 + inhibitor – ''Staphylococcus aureus''<br />
**[[5d6p]], [[5d6q]], [[5d7c]], [[5d7d]], [[5d7r]] - SaGyrB N-terminal + ligand<br />
**[[5d6p]], [[5d6q]], [[5d7c]], [[5d7d]], [[5d7r]] - SaGyrB N-terminal + ligand<br />
-
**[[5npk]], [[5npp]] - SaGyrB residues 410-1491 + DNA<br />
+
**[[5npk]], [[5npp]] - SaGyrB residues 410-543 + DNA<br />
**[[5mmn]], [[5mmo]], [[5mmp]] - EcGyrB N-terminal + antibacterial<br />
**[[5mmn]], [[5mmo]], [[5mmp]] - EcGyrB N-terminal + antibacterial<br />
**[[4urm]], [[4uro]] - SaGyrB N-terminal + antibiotic<br />
**[[4urm]], [[4uro]] - SaGyrB N-terminal + antibiotic<br />
**[[5zxm]] - SeGyrB N-terminal (mutant) <br />
**[[5zxm]] - SeGyrB N-terminal (mutant) <br />
 +
**[[6j90]] - SeGyrB N-terminal + ATP<br />
**[[3cwv]] – GyrB truncated – ''Myxococcus xanthus''<br />
**[[3cwv]] – GyrB truncated – ''Myxococcus xanthus''<br />
**[[4wub]], [[4wuc]], [[4wud]], [[4xtj]] - EcGyrB N-terminal<br />
**[[4wub]], [[4wuc]], [[4wud]], [[4xtj]] - EcGyrB N-terminal<br />
**[[1kzn]], [[1ei1]], [[1aj6]] - EcGyrB N-terminal+ antibiotic<br />
**[[1kzn]], [[1ei1]], [[1aj6]] - EcGyrB N-terminal+ antibiotic<br />
-
**[[4duh]], [[4zvi]], [[5l3j]], [[6f8j]], [[4hyp]], [[6f86]], [[5z9q]], [[5z9p]], [[5z9b]], [[5z9e]], [[5z9f]], [[5z9l]], [[5z9m]], [[5z9n]], [[5z4o]], [[5z4h]] - EcGyrB N-terminal+ inhibitor<br />
+
**[[4duh]], [[4zvi]], [[5l3j]], [[6f8j]], [[4hyp]], [[6f86]], [[5z9q]], [[5z9p]], [[5z9b]], [[5z9e]], [[5z9f]], [[5z9l]], [[5z9m]], [[5z9n]], [[5z4o]], [[5z4h]], [[6yd9]], [[7c7n]], [[7c7o]], [[7dor]], [[7dpr]], [[7dps]], [[7dqf]], [[7dqh]], [[7dqj]], [[7dqm]], [[7dqs]], [[7dqu]], [[7p2m]], [[7p2n]], [[7p2w]], [[7p2x]] - EcGyrB N-terminal+ inhibitor<br />
**[[4prv]], [[4prx]], [[4pu9]] - EcGyrB N-terminal+ ADP<br />
**[[4prv]], [[4prx]], [[4pu9]] - EcGyrB N-terminal+ ADP<br />
**[[5mmn]], [[5mmo]], [[5mmp]] - EcGyrB N-terminal + antibacterial<br />
**[[5mmn]], [[5mmo]], [[5mmp]] - EcGyrB N-terminal + antibacterial<br />
-
**[[6f96]], [[6f94]] - EcGyrB N-terminal + inhibitor<br />
+
**[[6f96]], [[6f94]], [[6kzv]], [[6kzx]], [[6kzz]], [[6l01]] - EcGyrB N-terminal + inhibitor<br />
**[[1kij]] – TtGyrB N-terminal+ antibiotic – ''Thermus thermophilus''<br />
**[[1kij]] – TtGyrB N-terminal+ antibiotic – ''Thermus thermophilus''<br />
**[[6enh]], [[6eng]] - TtGyrB ATPase domain + coumarine derivative<br />
**[[6enh]], [[6eng]] - TtGyrB ATPase domain + coumarine derivative<br />
-
**[[4b6c]] - GyrB N-terminal – ''Mycobacterium smegmatis''<br />
+
**[[4b6c]] - MsGyrB N-terminal – ''Mycobacterium smegmatis''<br />
-
**[[4gee]], [[4gfn]], [[4ggl]], [[4hxw]], [[4k4o]], [[4kfg]], [[4ksg]], [[4ksh]], [[4ktn]] – GyrB + inhibitor – ''Enterococcus faecalis''<br />
+
**[[6zt5]] - MsGyrB + MfpA<br />
 +
**[[6zt3]] - MsGyrB + ANP<br />
 +
**[[4gee]], [[4gfn]], [[4ggl]], [[4hxw]], [[4k4o]], [[4kfg]], [[4ksg]], [[4ksh]], [[4ktn]] – GyrB N-terminal + inhibitor – ''Enterococcus faecalis''<br />
**[[2zjt]], [[3ig0]], [[3m4i]] - MtGyrB C-terminal<br />
**[[2zjt]], [[3ig0]], [[3m4i]] - MtGyrB C-terminal<br />
**[[3zkb]], [[3zkd]] - MtGyrB N-terminal + AMPPNP<br />
**[[3zkb]], [[3zkd]] - MtGyrB N-terminal + AMPPNP<br />
**[[3zm7]] - MtGyrB N-terminal + AMPPCP<br />
**[[3zm7]] - MtGyrB N-terminal + AMPPCP<br />
**[[4bae]] - MtGyrB N-terminal (mutant) + inhibitor<br />
**[[4bae]] - MtGyrB N-terminal (mutant) + inhibitor<br />
 +
**[[6j90]] - GyrB N-terminal + ATP – ''Salmonella typhi''<br />
 +
**[[6m1j]], [[6m1s]], [[7ptf]], [[7ptg]], [[8bn6]] - GyrB ATPase domain + inhibitor – ''Pseudomonas aeruginosa''<br />
 +
**[[6y8l]], [[6y8n]], [[6y8o]] - GyrB ATPase domain + drug – ''Mycobacterium thermoresistibile''<br />
 +
**[[7pqm]] - AbGyrB ATPase domain + inhibitor – Acinetobacter baumannii<br />
 +
**[[7pqi]] - AbGyrB ATPase domain + antibiotic<br />
*Gyrase Subunit A+Subunit B
*Gyrase Subunit A+Subunit B
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**[[2xct]] - SaGyrB C-terminal/SaGyrA N-terminal (mutant) +DNA+ antibiotic<br />
**[[2xct]] - SaGyrB C-terminal/SaGyrA N-terminal (mutant) +DNA+ antibiotic<br />
**[[4tma]] - SaGyrB C-terminal- + SaGyrA N-terminal + Gyr inhibitor YACG<br />
**[[4tma]] - SaGyrB C-terminal- + SaGyrA N-terminal + Gyr inhibitor YACG<br />
-
**[[5cdn]], [[5cdo]], [[5cdp]], [[6fqv]] – SaGyrA + SaGyrB + DNA<br />
+
**[[5cdn]], [[5cdo]], [[5cdp]], [[6fqv]], [[6z1a]] – SaGyrA + SaGyrB + DNA<br />
**[[6qx2]], [[6qx1]], [[6qtp]], [[6qtk]] – SaGyrA + SaGyrB + DNA + inhibitor<br />
**[[6qx2]], [[6qx1]], [[6qtp]], [[6qtk]] – SaGyrA + SaGyrB + DNA + inhibitor<br />
**[[5cdq]], [[6fqm]], [[6fqs]] - SaGyrB + GyrA + DNA + antibiotic<br />
**[[5cdq]], [[6fqm]], [[6fqs]] - SaGyrB + GyrA + DNA + antibiotic<br />
-
**[[5bs3]], [[5iwi]], [[5iwm]] - SaGyrB + GyrA + DNA + inhibitor<br />
+
**[[5bs3]], [[5iwi]], [[5iwm]], [[6qx2]], [[6qx1]], [[6qtp]], [[6qtk]] - SaGyrB + GyrA + DNA + inhibitor<br />
-
**[[6fm4]] - SaGyrB (mutant) + GyrA + DNA + inhibitor<br />
+
**[[6fm4]], [[7mvs]] - SaGyrB (mutant) + GyrA + DNA + inhibitor<br />
**[[5cdm]] – SaGyrA + SaGyrB (mutant) + DNA<br />
**[[5cdm]] – SaGyrA + SaGyrB (mutant) + DNA<br />
**[[5cdr]] – SaGyrA (mutant) + SaGyrB (mutant) + DNA<br />
**[[5cdr]] – SaGyrA (mutant) + SaGyrB (mutant) + DNA<br />
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**[[5bs8]], [[5bta]], [[5btd]], [[5btg]], [[5btl]] - MtGyrB + GyrA + DNA + antibiotic<br />
**[[5bs8]], [[5bta]], [[5btd]], [[5btg]], [[5btl]] - MtGyrB + GyrA + DNA + antibiotic<br />
**[[5btc]], [[5btf]], [[5bti]], [[5btn]] - MtGyrB + GyrA (mutant) + DNA + antibiotic<br />
**[[5btc]], [[5btf]], [[5bti]], [[5btn]] - MtGyrB + GyrA (mutant) + DNA + antibiotic<br />
 +
**[[7ugw]] - MtGyrB + GyrA (mutant) + DNA + inhibitor<br />
**[[3nuh]] – EcGyrA+EcGyrB<br />
**[[3nuh]] – EcGyrA+EcGyrB<br />
 +
**[[6rks]], [[6rku]], [[6rkv]], [[6rkw]] - EcGyrA + GyrB + DNA – Cryo EM<br />
 +
**[[7z9c]], [[7z9g]], [[7z9k]] - EcGyrA + GyrB + DNA + antibiotic – Cryo EM<br />
 +
 +
*Gyrase
 +
 +
**[[6ca8]] – Gyr residues 469-1212 – ''Plasmodium falciparum''<br />
*Reverse Gyrase
*Reverse Gyrase

Current revision

3D Structure of Gyrase

Updated on 27-April-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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