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Heat Shock Protein structures
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**[[4ylb]], [[4ylc]] - SsHsp20 (mutant)<br /> | **[[4ylb]], [[4ylc]] - SsHsp20 (mutant)<br /> | ||
**[[5z81]] – VcHsp15 – ''Vibrio cholerae''<br /> | **[[5z81]] – VcHsp15 – ''Vibrio cholerae''<br /> | ||
| + | **[[4i2n]] – VcHsp31<br /> | ||
**[[3bbu]] – EcHsp15 - ''Escherichia coli'' – Cryo-EM<br /> | **[[3bbu]] – EcHsp15 - ''Escherichia coli'' – Cryo-EM<br /> | ||
| + | **[[1dm9]] – EcHsp15<br /> | ||
| + | **[[8ap4]] – EcHsp15 in 50S ribosome – Cryo-EM<br /> | ||
**[[1ons]] – EcHsp31<br /> | **[[1ons]] – EcHsp31<br /> | ||
**[[3gla]], [[3gt6]], [[3guf]] – Hsp – ''Xanthomonas axonopodis''<br /> | **[[3gla]], [[3gt6]], [[3guf]] – Hsp – ''Xanthomonas axonopodis''<br /> | ||
| - | **[[3vqk]] – StHsp14 – ''Sulfolobus tokodaii''<br /> | + | **[[3aac]], [3vqk]] – StHsp14 – ''Sulfolobus tokodaii''<br /> |
| - | **[[3vql]], [[3vqm]] – StHsp14 (mutant)<br /> | + | **[[3aab]], [[3vql]], [[3vqm]] – StHsp14 (mutant)<br /> |
**[[3w1z]] – Hsp16 – ''Schizosacchromyces pombe''<br /> | **[[3w1z]] – Hsp16 – ''Schizosacchromyces pombe''<br /> | ||
**[[5j7n]] – Hsp – ''Xylella fastidiosa''<br /> | **[[5j7n]] – Hsp – ''Xylella fastidiosa''<br /> | ||
| + | **[[6l6m]] – Hsp18.5 – ''Entamoeba histolytica''<br /> | ||
| + | **[[4fei]] – Hsp17.7 – ''Deinococcus radiodurans''<br /> | ||
**[[1shs]], [[4eld]], [[4i88]] – Hsp – ''Methanococcus jannaschii''<br /> | **[[1shs]], [[4eld]], [[4i88]] – Hsp – ''Methanococcus jannaschii''<br /> | ||
**[[2bol]] – Hsp – ''Taenia saginata''<br /> | **[[2bol]] – Hsp – ''Taenia saginata''<br /> | ||
| Line 45: | Line 50: | ||
*Hsp33 | *Hsp33 | ||
| + | **[[3kkl]] – yHsp33 <br /> | ||
**[[1hw7]], [[3m7m]] – EcHsp33 NTD <br /> | **[[1hw7]], [[3m7m]] – EcHsp33 NTD <br /> | ||
**[[1i7f]] – EcHsp33 chaperone domain (mutant)<br /> | **[[1i7f]] – EcHsp33 chaperone domain (mutant)<br /> | ||
| Line 69: | Line 75: | ||
**[[2qld]] – hHsp40 residues 158-340<br /> | **[[2qld]] – hHsp40 residues 158-340<br /> | ||
| - | **[[1hdj]], [[2ctq]], [[6iws]] – hHsp40 J domain 1-76 - NMR<br /> | + | **[[1hdj]], [[2ctq]], [[2lgw]], [[2m6y]], [[6iws]] – hHsp40 J domain 1-76 - NMR<br /> |
| + | **[[6byr]] – hHsp40 J domain 1-70 + CAMP-dependent protein kinase<br /> | ||
**[[6z5n]] – hHsp40 1-110 – NMR<br /> | **[[6z5n]] – hHsp40 1-110 – NMR<br /> | ||
**[[6cgh]] – hHsp40 346-432 – NMR<br /> | **[[6cgh]] – hHsp40 346-432 – NMR<br /> | ||
**[[6u3r]], [[6u3s]] – hHsp40 1-127+CT – NMR<br /> | **[[6u3r]], [[6u3s]] – hHsp40 1-127+CT – NMR<br /> | ||
**[[7jsq]] – hHsp40 CT – NMR<br /> | **[[7jsq]] – hHsp40 CT – NMR<br /> | ||
| + | **[[7ndx]] – hHsp40 CT + NudC peptide<br /> | ||
**[[7ciz]], [[7cj0]] – hHsp40 CT + DNA replication licensing factor + histone H3.4 + histone H4<br /> | **[[7ciz]], [[7cj0]] – hHsp40 CT + DNA replication licensing factor + histone H3.4 + histone H4<br /> | ||
**[[6jmg]] – DnaJ + GTP - frog<br /> | **[[6jmg]] – DnaJ + GTP - frog<br /> | ||
| Line 90: | Line 98: | ||
*Hsp47 | *Hsp47 | ||
| - | **[[3zha]] – dHsp47 + collagen peptide | + | **[[4au4]] – dHsp47 - dog<br /> |
| + | **[[3zha]] – dHsp47 + collagen peptide<br /> | ||
* Hsp60 mitochondrial | * Hsp60 mitochondrial | ||
| - | **[[7azp]] – hHsp60 – Cryo EM<br /> | + | **[[7azp]], [[7l7l]], [[7l7s]] – hHsp60 – Cryo EM<br /> |
| - | **[[4pj1]], [[6ht7]] – hHsp60 + hHsp10<br /> | + | **[[4pj1]], [[6ht7]] – hHsp60 + hHsp10 + ADP<br /> |
**[[6mrc]], [[6mrd]] – hHsp60 + hHsp10 + ADP – Cryo EM<br /> | **[[6mrc]], [[6mrd]] – hHsp60 + hHsp10 + ADP – Cryo EM<br /> | ||
| Line 103: | Line 112: | ||
**[[3iyf]] - MmHsp60 - GroEL – open state<br /> | **[[3iyf]] - MmHsp60 - GroEL – open state<br /> | ||
**[[3e76]] – EcHsp60 – GroEL+Tl ion – ''Escherichia coli''<br /> | **[[3e76]] – EcHsp60 – GroEL+Tl ion – ''Escherichia coli''<br /> | ||
| - | **[[2nwc]], [[1oel]], [[1grl]], [[1la1]] - EcHsp60 – GroEL<br /> | + | **[[2nwc]], [[1oel]], [[1grl]], [[1la1]], [[7v98]] - EcHsp60 – GroEL<br /> |
| - | **[[2eu1]] - EcHsp60 (mutant) – GroEL<br /> | + | **[[2eu1]], [[7v9r]] - EcHsp60 (mutant) – GroEL<br /> |
**[[2cgt]] - EcHsp60 – GroEL+ADP+capsid assembly protein Gp31<br /> | **[[2cgt]] - EcHsp60 – GroEL+ADP+capsid assembly protein Gp31<br /> | ||
**[[2c7c]], [[2c7d]] - EcHsp60 – GroEL+GroES – cryo EM<br /> | **[[2c7c]], [[2c7d]] - EcHsp60 – GroEL+GroES – cryo EM<br /> | ||
| Line 115: | Line 124: | ||
**[[4v4o]] - TtHsp60 – GroEL+GroES <br /> | **[[4v4o]] - TtHsp60 – GroEL+GroES <br /> | ||
**[[1ass]], [[1asx]] - Hsp60 – GroEL apical domain – ''Thermoplasma acidophilum''<br /> | **[[1ass]], [[1asx]] - Hsp60 – GroEL apical domain – ''Thermoplasma acidophilum''<br /> | ||
| + | |||
| + | * Hsp65 | ||
| + | |||
| + | **[[3rtk]] – MtHsp65 – ''Mycobacterium tuberculosis''<br /> | ||
* Hsp70 – 3 domains: N-terminus ATPase hydrolyzes ATP to ADP (NBD) residues 1-380; hydrophobic amino acid binding domain (SBD) residues 381-564: C-terminus lid domain (CT) residues 534-641. | * Hsp70 – 3 domains: N-terminus ATPase hydrolyzes ATP to ADP (NBD) residues 1-380; hydrophobic amino acid binding domain (SBD) residues 381-564: C-terminus lid domain (CT) residues 534-641. | ||
| Line 150: | Line 163: | ||
**[[6s02]] – PfHsp70 NTD+ADP <br /> | **[[6s02]] – PfHsp70 NTD+ADP <br /> | ||
**[[7ooe]], [[7oog]], [[7ooh]], [[7p31]] – PfHsp70 NTD+AMP derivative + inhibitor <br /> | **[[7ooe]], [[7oog]], [[7ooh]], [[7p31]] – PfHsp70 NTD+AMP derivative + inhibitor <br /> | ||
| + | **[[7nqr]], [[7nqs]], [[7nqu]], [[7nqz]] - PfHsp70 NBD + inhibitor<br /> | ||
**[[6zhi]] - PfHsp70 CT + peptide<br /> | **[[6zhi]] - PfHsp70 CT + peptide<br /> | ||
| Line 161: | Line 175: | ||
**[[4b9q]] - EcDnaK NBD + SBD + ATP<br /> | **[[4b9q]] - EcDnaK NBD + SBD + ATP<br /> | ||
| + | **[[7ko2]], [[7krt]], [[7kru]], [[7krv]] - EcDnaK (mutant) + ATP<br /> | ||
**[[5oow]] - EcDnaK + AMPPCP<br /> | **[[5oow]] - EcDnaK + AMPPCP<br /> | ||
**[[5nro]] – EcDnaK (mutant) + DnaJ<br /> | **[[5nro]] – EcDnaK (mutant) + DnaJ<br /> | ||
| Line 172: | Line 187: | ||
**[[1q5l]] - EcDnaK SBD + peptide – NMR<br /> | **[[1q5l]] - EcDnaK SBD + peptide – NMR<br /> | ||
**[[3dpp]], [[3dpq]], [[3dpo]], [[1dky]], [[3qnj]], [[4e81]], [[4ezn]], [[4ezo]], [[4ezp]], [[4ezq]], [[4ezr]], [[4ezs]], [[4ezt]], [[4ezu]], [[4ezv]], [[4ezw]], [[4ezx]], [[4ezy]], [[4ezz]], [[4f00]], [[4hy9]], [[4hyb]], [[4jwc]], [[4jwd]], [[4jwe]], [[4jwi]], [[4r5i]], [[4f01]], [[7jmm]], [[7jn8]], [[7jn9]], [[7jne]], [[7n6j]], [[7n6k]], [[7n6l]], [[7n6m]] – EcDnaK SBD + peptide<br /> | **[[3dpp]], [[3dpq]], [[3dpo]], [[1dky]], [[3qnj]], [[4e81]], [[4ezn]], [[4ezo]], [[4ezp]], [[4ezq]], [[4ezr]], [[4ezs]], [[4ezt]], [[4ezu]], [[4ezv]], [[4ezw]], [[4ezx]], [[4ezy]], [[4ezz]], [[4f00]], [[4hy9]], [[4hyb]], [[4jwc]], [[4jwd]], [[4jwe]], [[4jwi]], [[4r5i]], [[4f01]], [[7jmm]], [[7jn8]], [[7jn9]], [[7jne]], [[7n6j]], [[7n6k]], [[7n6l]], [[7n6m]] – EcDnaK SBD + peptide<br /> | ||
| - | **[[7kzi]], [[7kzu]] – EcDnaK/peptide<br /> | + | **[[7krw]], [[7kzi]], [[7kzu]] – EcDnaK/peptide<br /> |
**[[1q5l]] - EcDnaK SBD +peptide – NMR<br /> | **[[1q5l]] - EcDnaK SBD +peptide – NMR<br /> | ||
**[[4r5g]] - EcDnaK CT + inhibitor<br /> | **[[4r5g]] - EcDnaK CT + inhibitor<br /> | ||
| Line 186: | Line 201: | ||
**[[5f3k]], [[5f5r]] – hHsp75 NTD<br /> | **[[5f3k]], [[5f5r]] – hHsp75 NTD<br /> | ||
| - | **[[5hph]] – hHsp75 residues 60-554<br /> | + | **[[5hph]], [[7ulk]] – hHsp75 residues 60-554<br /> |
**[[4z1f]], [[4z1g]], [[4z1h]], [[4z1i]], [[5y3n]], [[5y3o]], [[7c04]], [[7c05]], [[7c7b]], [[7c7c]] – hHsp75 + inhibitor<br /> | **[[4z1f]], [[4z1g]], [[4z1h]], [[4z1i]], [[5y3n]], [[5y3o]], [[7c04]], [[7c05]], [[7c7b]], [[7c7c]] – hHsp75 + inhibitor<br /> | ||
| + | **[[6xg6]] – hHsp75 residues 60-704 + ADP – Cryo EM<br /> | ||
| + | **[[7kck]], [[7klu]], [[7klv]] – hHsp75 residues 60-704 + AMPPNP – Cryo EM<br /> | ||
| + | **[[7kcl]], [[7kcm]] – hHsp75 residues 60-704 + SDHB + AMPPNP – Cryo EM<br /> | ||
*Hsp83 | *Hsp83 | ||
| Line 193: | Line 211: | ||
**[[3u67]] – LmHsp83 NTD + ADP – ''Leishmania major'' | **[[3u67]] – LmHsp83 NTD + ADP – ''Leishmania major'' | ||
| - | * Hsp90 – 4 domains: N-terminus (NTD) residues 1-236; linker; middle (MD); C-terminus (CT) | + | * Hsp90 – 4 domains: N-terminus (NTD) residues 1-236; linker 237-283; middle (MD) 284-543; C-terminus (CT) |
*''Hsp90-α NTD'' | *''Hsp90-α NTD'' | ||
| - | **[[3t0h]], [[5j2v]], [[6gpw]] - hHsp90 NTD – human<br /> | + | **[[3t0h]], [[5j2v]], [[6gpw]], [[7s8y]], [[7s8z]][[5xr]], - hHsp90 NTD – human<br /> |
**[[5j80]], [[6gr4]], [[6gp4]] - hHsp90 NTD (mutant)<br /> | **[[5j80]], [[6gr4]], [[6gp4]] - hHsp90 NTD (mutant)<br /> | ||
**[[2h8m]], [[2hch]], [[2gqp]] – dHsp90B1 NTD <br /> | **[[2h8m]], [[2hch]], [[2gqp]] – dHsp90B1 NTD <br /> | ||
| Line 216: | Line 234: | ||
**[[2k5b]] - hHsp90 NTD+Cdc37 – NMR - docking<br /> | **[[2k5b]] - hHsp90 NTD+Cdc37 – NMR - docking<br /> | ||
**[[3eko]], [[3ekr]] - hHsp90 NTD+dihydroxyphenyl amide<br /> | **[[3eko]], [[3ekr]] - hHsp90 NTD+dihydroxyphenyl amide<br /> | ||
| - | **[[3bm9]], [[3bmy]], [[5xre]], [[5xrb]], [[5xr9]], [[5xr5]], [[5xqe]], [[5xqd]] - hHsp90 NTD+ oxazole derivative<br /> | + | **[[3bm9]], [[3bmy]], [[5xrd]], [[5xre]], [[5xrb]], [[5xr9]], [[5xr5]], [[5xqe]], [[5xqd]] - hHsp90 NTD+ oxazole derivative<br /> |
**[[2of6]], [[3b24]], [[3b27]], [[3b28]], [[3r92]] - hHsp90 NTD+triazine derivative<br /> | **[[2of6]], [[3b24]], [[3b27]], [[3b28]], [[3r92]] - hHsp90 NTD+triazine derivative<br /> | ||
| - | **[[5j20]], [[5j27]], [[5j2x]], [[5j64]], [[5j6l]], [[5j6m]], [[5j82]], [[5j86]], [[5j8m]], [[5j6n]], [[5j8u]], [[5j9x]] - hHsp90-α NTD - hHsp90-a NTD+triazol derivative<br /> | + | **[[5j20]], [[5j27]], [[5j2x]], [[5j64]], [[5j6l]], [[5j6m]], [[5j82]], [[5j86]], [[5j8m]], [[5j6n]], [[5j8u]], [[5j9x]], [[8agi]], [[8agl]] - hHsp90-α NTD +triazol derivative<br /> |
| - | **[[2qfo]], [[3nmq]], [[3r4m]], [[3r4n]], [[3r4o]], [[3r4p]], [[3b25]], [[3b26]], [[2jcc]], [[3rlp]], [[3rlq]], [[3rlr]], [[2wi1]], [[2wi2]], [[2wi3]], [[2wi4]], [[2wi5]], [[2wi6]], [[2wi7]], [[2jjc]], [[5fnc]] - hHsp90 NTD+pyrimidine derivative<br /> | + | **[[8agj]] - hHsp90-a NTD (mutant) +triazol derivative<br /> |
| + | **[[2qfo]], [[3nmq]], [[3r4m]], [[3r4n]], [[3r4o]], [[3r4p]], [[3b25]], [[3b26]], [[2jcc]], [[3rlp]], [[3rlq]], [[3rlr]], [[2wi1]], [[2wi2]], [[2wi3]], [[2wi4]], [[2wi5]], [[2wi6]], [[2wi7]], [[2jjc]], [[5fnc]], [[7dmc]], [[7s98]], [[7s99]], [[7s9f]], [[7s9g]], [[7s9h]], [[7s9i]] - hHsp90 NTD+pyrimidine derivative<br /> | ||
| + | **[[7a90]], [[7s95]] - hHsp90 NTD+ adenine <br /> | ||
**[[6f1n]] - hHsp90 NTD+pyridine derivative<br /> | **[[6f1n]] - hHsp90 NTD+pyridine derivative<br /> | ||
**[[1uy6]], [[1uy7]], [[1uy8]], [[1uy9]], [[1uyc]], [[1uyd]], [[1uye]], [[1uyf]], [[1uyg]], [[1uyh]], [[1uyi]], [[1uyk]], [[1uyl]], [[6el5]], [[2fwy]], [[2fwz]], [[2h55]], [[3o0i]], [[6cyh]], [[6cyg]], [[6b9a]], [[6b99]] - hHsp90 NTD+purine derivative<br /> | **[[1uy6]], [[1uy7]], [[1uy8]], [[1uy9]], [[1uyc]], [[1uyd]], [[1uye]], [[1uyf]], [[1uyg]], [[1uyh]], [[1uyi]], [[1uyk]], [[1uyl]], [[6el5]], [[2fwy]], [[2fwz]], [[2h55]], [[3o0i]], [[6cyh]], [[6cyg]], [[6b9a]], [[6b99]] - hHsp90 NTD+purine derivative<br /> | ||
| Line 253: | Line 273: | ||
**[[6cjr]], [[6cjs]] – CaHsp90 NTD + inhibitor<br /> | **[[6cjr]], [[6cjs]] – CaHsp90 NTD + inhibitor<br /> | ||
**[[7k9s]], [[7k9u]], [[7k9v]], [[7k9w]] – CnHsp90 NTD + inhibitor<br /> | **[[7k9s]], [[7k9u]], [[7k9v]], [[7k9w]] – CnHsp90 NTD + inhibitor<br /> | ||
| + | |||
| + | *''Hsp90-a NTD+linker residues 1-293'' | ||
| + | |||
| + | **[[7ur3]] - hHsp90 + inhibitor <br /> | ||
*''Hsp90-α MD'' | *''Hsp90-α MD'' | ||
| + | **[[6ksq]] - hHsp90 MD <br /> | ||
**[[2gq0]] - EcHsp90 MD<br /> | **[[2gq0]] - EcHsp90 MD<br /> | ||
| Line 269: | Line 294: | ||
*''Hsp90-α MD + CT'' residues 293-732 | *''Hsp90-α MD + CT'' residues 293-732 | ||
| - | **[[3q6m]], [[3q6n]] - hHsp90 MD + CT<br /> | + | **[[3q6m]], [[3q6n]], [[7rxz]], [[7ry0]], [[7ry1]] - hHsp90 MD + CT<br /> |
**[[2o1t]] – dHsp90B1 MD+CT<br /> | **[[2o1t]] – dHsp90B1 MD+CT<br /> | ||
| - | *''Hsp90-α full length'' | + | *''Hsp90-α full length 1-732'' |
| - | **[[6xg6]] - hHsp90 + ADP – Cryo EM <br /> | ||
**[[2qf6]] - hHsp90 + antigen<br /> | **[[2qf6]] - hHsp90 + antigen<br /> | ||
**[[5fwk]], [[5fwl]], [[5fwm]], [[5fwp]] – hHsp90 + CDC37 + CDK4<br /> | **[[5fwk]], [[5fwl]], [[5fwm]], [[5fwp]] – hHsp90 + CDC37 + CDK4<br /> | ||
| + | **[[7l7j]] - hHsp90 + P23 + ANP – Cryo EM <br /> | ||
| + | **[[7krj]] - hHsp90 + GR + P23 + ATP – Cryo EM <br /> | ||
| + | **[[8h77]] - hHsp90 + AhR + P23 + XAP2 + ADP – Cryo EM <br /> | ||
| + | **[[7l7i]] - hHsp90 + FKBP51 + P23 + ANP – Cryo EM <br /> | ||
| + | **[[7kw7]] - hHsp90 + Hsp70 + GR + STI1 + ADP – Cryo EM <br /> | ||
**[[2o1u]] – dHsp90B1+AMPPNP<br /> | **[[2o1u]] – dHsp90B1+AMPPNP<br /> | ||
**[[2o1v]] - dHsp90B1+ADP<br /> | **[[2o1v]] - dHsp90B1+ADP<br /> | ||
| Line 284: | Line 313: | ||
*Hsp90-β | *Hsp90-β | ||
| + | **[[8eob]] - hHsp90 – Cryo EM <br /> | ||
**[[6n8w]] - hHsp90 NTD <br /> | **[[6n8w]] - hHsp90 NTD <br /> | ||
**[[5fwk]], [[5fwl]], [[5fwm]], [[5fwp]] – hHsp90 + CDC37 + CDK4<br /> | **[[5fwk]], [[5fwl]], [[5fwm]], [[5fwp]] – hHsp90 + CDC37 + CDK4<br /> | ||
| - | **[[1uym]], [[6n8y]] - hHsp90 NTD+ purine inhibitor<br /> | + | **[[1uym]], [[6n8y]], [[7ulj]] - hHsp90 NTD+ purine inhibitor<br /> |
**[[5uc4]], [[5uch]], [[5uci]], [[5ucj]], [[4o04]], [[4o05]], **[[4o07]] - hHsp90-b NTD + inhibitor<br /> | **[[5uc4]], [[5uch]], [[5uci]], [[5ucj]], [[4o04]], [[4o05]], **[[4o07]] - hHsp90-b NTD + inhibitor<br /> | ||
**[[3nmq]] - hHsp90 NTD+pyrimidine derivative | **[[3nmq]] - hHsp90 NTD+pyrimidine derivative | ||
**[[3pry]] – hHsp90 MD<br /> | **[[3pry]] – hHsp90 MD<br /> | ||
| + | **[[7zub]] - hHsp90 + AIP + AH receptor + ADP - Cryo EM <br /> | ||
| + | **[[8e0a]] - hHsp90 + AIPL1 + ANP – Cryo EM <br /> | ||
| + | **[[7z37]], [[7z38]] - hHsp90 + Cdc37 + RAF-1 – Cryo EM <br /> | ||
| + | **[[8gae]] - hHsp90 + Cdc37 + RAF-1 + PP5 – Cryo EM <br /> | ||
| + | **[[7zr0]] - hHsp90 + Cdc37 + BRAF – Cryo EM <br /> | ||
| + | **[[7zr5]], [[7zr6]] - hHsp90 + Cdc37 + BRAF + PP5 – Cryo EM <br /> | ||
| + | **[[7y04]] - mHsp90 + AH receptor + P23 + ADP - mouse - Cryo EM <br /> | ||
* Hsp82 is the yeast equivalent of Hsp90 in mammals | * Hsp82 is the yeast equivalent of Hsp90 in mammals | ||
| Line 331: | Line 368: | ||
**[[1khy]] – EcClpB NTD <br /> | **[[1khy]] – EcClpB NTD <br /> | ||
**[[1jbk]] – EcClpB nucleotide binding domain 1<br /> | **[[1jbk]] – EcClpB nucleotide binding domain 1<br /> | ||
| + | **[[1yg6]] – EcClpP<br /> | ||
| + | **[[1yg8]], [[3hln]] – EcClpP (mutant)<br /> | ||
| + | **[[2fzs]], [[7mk5]] – EcClpP + inhibitor<br /> | ||
| + | **[[6nb1]] – EcClpP + activator<br /> | ||
| + | **[[3mt6]] – EcClpP + Adep1<br /> | ||
| + | **[[6wr2]], [[6wsg]] – EcClpP + ClpX – Cryo EM<br /> | ||
| + | **[[6wrf]] – EcClpP + ClpX + GFP – Cryo EM<br /> | ||
| + | **[[8et3]] – EcClpP + ClpX + GFP + SSPB – Cryo EM<br /> | ||
**[[4iod]], [[4irf]] - PfClpB <br /> | **[[4iod]], [[4irf]] - PfClpB <br /> | ||
**[[1qvr]] - TtClpB <br /> | **[[1qvr]] - TtClpB <br /> | ||
| Line 356: | Line 401: | ||
**[[7m1l]], [[7m1m]] – ClpP2 – ''Pseudomonas aeruginosa''<br /> | **[[7m1l]], [[7m1m]] – ClpP2 – ''Pseudomonas aeruginosa''<br /> | ||
**[[6cfd]] – ClpP + antibiotic – ''Enterococcus faecium''<br /> | **[[6cfd]] – ClpP + antibiotic – ''Enterococcus faecium''<br /> | ||
| + | **[[7tfm]] – ClpP N-domain – ''Leishmania mexicana''<br /> | ||
*Hsp101 | *Hsp101 | ||
| Line 369: | Line 415: | ||
**[[5vy9]], [[5vya]] – yHsp104 + casein<br /> | **[[5vy9]], [[5vya]] – yHsp104 + casein<br /> | ||
**[[5vjh]] – yHsp104 + casein + ATP-γ-S<br /> | **[[5vjh]] – yHsp104 + casein + ATP-γ-S<br /> | ||
| - | **[[5u2l]] – | + | **[[5u2l]] – CaHsp104 NTD – ''Candida albicans''<br /> |
**[[6d00]] – CtHsp104 – ''Calcarisporiella thermophila'' - Cryo EM<br /> | **[[6d00]] – CtHsp104 – ''Calcarisporiella thermophila'' - Cryo EM<br /> | ||
**[[6azy]] – CtHsp104 (mutant)<br /> | **[[6azy]] – CtHsp104 (mutant)<br /> | ||
| - | **[[5zui]] – | + | **[[5zui]] – ChtHsp104 – ''Chaetomium thermophilum''<br /> |
| + | **[[7cg3]] – ChtHsp104 - Cryo EM<br /> | ||
| + | **[[5d4w]] – ChtHsp104 (mutant)<br /> | ||
* Hsp110 in mammals is named Sse1, Sse2 in yeast | * Hsp110 in mammals is named Sse1, Sse2 in yeast | ||
| Line 383: | Line 431: | ||
**[[3upv]] – ySti1 TPR repeats 7-9 + ySse1 peptide<br /> | **[[3upv]] – ySti1 TPR repeats 7-9 + ySse1 peptide<br /> | ||
**[[3uq3]] - ySti1 TPR repeats 4-9 + peptide<br /> | **[[3uq3]] - ySti1 TPR repeats 4-9 + peptide<br /> | ||
| - | **[[3lca]] – ySsa1 lid +yTOM71<br /> | ||
**[[5z8q]], [[5z8i]] – ySsa1 SBD - NMR<br /> | **[[5z8q]], [[5z8i]] – ySsa1 SBD - NMR<br /> | ||
| + | |||
| + | *HspA5 or Grp78 or Endoplasmic reticulum chaperone BIP or 78 kDa glucose-related protein; Domains – NBD 26-407; SBD 418-637 | ||
| + | |||
| + | **[[3ldn]] – hHspA5 NBD<br /> | ||
| + | **[[5e85]] – hHspA5 SBD domain <br /> | ||
| + | **[[5ex5]], [[5exw]], [[5ey4]] – hHspA5 + ATP analog<br /> | ||
| + | **[[3ldl]], [[5e84]], [[5f1x]], [[6asy]] – hHspA5 + ATP<br /> | ||
| + | **[[3iuc]], [[5evz]], [[5f0x]] – hHspA5 + ADP derivative<br /> | ||
| + | **[[5f2r]] – hHspA5 + ACP<br /> | ||
| + | **[[3ldo]] – hHspA5 + ANP<br /> | ||
| + | **[[3ldp]] – hHspA5 + inhibitor<br /> | ||
| + | **[[6cz1]], [[6dfm]], [[6dfo]], [[6do2]], [[6dws]] – hHspA5 + adenosine derivative<br /> | ||
| + | **[[6zmd]] – hHspA5 + FICD + ANP <br /> | ||
| + | **[[6eob]], [[6eoc]], [[7a4u]] – haHspA5 28-549 - hamster<br /> | ||
| + | **[[6hab]] – haHspA5 (mutant)<br /> | ||
| + | **[[5e86]] – haHspA5 SBD <br /> | ||
| + | **[[6zyh]], [[7a4v]] – haHspA5 + ADP <br /> | ||
| + | **[[5o4p]] – haHspA5 + AMP<br /> | ||
| + | **[[6eof]] – haHspA5 + AMP + ADP<br /> | ||
| + | **[[6eoe]] – haHspA5 + ADP<br /> | ||
| + | **[[7b7z]], [[7b80]] – haHspA5 + FICD + AMP <br /> | ||
| + | **[[6h9u]], [[6ha7]] – haHspA5 NBD + MANF<br /> | ||
*HspQ | *HspQ | ||
**[[5ycq]] – EcHspQ<br /> | **[[5ycq]] – EcHspQ<br /> | ||
| + | |||
| + | *Hsp DegP or Periplasmic serine endoprotease DegP; Domains PDZ1 38-385; PDZ2 400-474 | ||
| + | |||
| + | **[[3mh4]] – EcDegP <br /> | ||
| + | **[[1ky9]] – EcDegP (mutant) <br /> | ||
| + | **[[8f0a]], [[8f0u]], [[8f1t]], [[8f1u]], [[8f21]] – EcDegP + telomeric repeat-binding factor peptide – Cryo EM<br /> | ||
| + | **[[2zle]], [[4a8d]] – EcDegP + OmpC – Cryo EM<br /> | ||
| + | **[[3cs0]], [[3mh5]], [[3mh6]], [[3mh7]], [[3ou0]], [[6jjk]], [[6jjl]], [[6jjo]] – EcDegP + peptide <br /> | ||
| + | **[[3otp]] – EcDegP + lysozyme <br /> | ||
*'''Heat shock cognate protein (Hsc)''' | *'''Heat shock cognate protein (Hsc)''' | ||
| + | |||
| + | *''Hsc20'' | ||
| + | |||
| + | **[[3bvo]] - hHsc20<br /> | ||
*''Hsc70'' | *''Hsc70'' | ||
| Line 398: | Line 480: | ||
**[[3fzk]], [[3fzl]] - hHsc70 NBD+BAG domain regulator protein+ purine derivative<br /> | **[[3fzk]], [[3fzl]] - hHsc70 NBD+BAG domain regulator protein+ purine derivative<br /> | ||
**[[4h5n]], [[4h5r]], [[4h5v]], [[4h5w]] - hHsc70 NBD<br /> | **[[4h5n]], [[4h5r]], [[4h5v]], [[4h5w]] - hHsc70 NBD<br /> | ||
| - | **[[4h5t]] - hHsc70 NBD + ADP<br /> | + | **[[4h5t]], [[6zyj]] - hHsc70 NBD + ADP<br /> |
**[[4hwi]], [[5aqf]], [[5aqg]], [[5aqh]], [[5aqi]], [[5aqj]], [[5aqgk]], [[5aql]], [[5aqm]], [[5aqn]], [[5aqo]], [[5aqp]], [[5aqq]], [[5aqr]], [[5aqs]], [[5aqt]], [[5aqu]], [[5aqv]] - hHsc70 NBD+BAG domain regulator protein<br /> | **[[4hwi]], [[5aqf]], [[5aqg]], [[5aqh]], [[5aqi]], [[5aqj]], [[5aqgk]], [[5aql]], [[5aqm]], [[5aqn]], [[5aqo]], [[5aqp]], [[5aqq]], [[5aqr]], [[5aqs]], [[5aqt]], [[5aqu]], [[5aqv]] - hHsc70 NBD+BAG domain regulator protein<br /> | ||
**[[2qw9]] – bHsc70 NBD – bovine<br /> | **[[2qw9]] – bHsc70 NBD – bovine<br /> | ||
| Line 412: | Line 494: | ||
**[[2v7z]] – rHsc70 NBD + SBD – rat<br /> | **[[2v7z]] – rHsc70 NBD + SBD – rat<br /> | ||
**[[7hsc]], [[1ckr]] - rHsc70 sub - NMR<br /> | **[[7hsc]], [[1ckr]] - rHsc70 sub - NMR<br /> | ||
| - | **[[3cqx]] - Hsc70 NBD+BAG domain regulator protein – | + | **[[3cqx]] - Hsc70 NBD+BAG domain regulator protein <br /> |
| + | |||
| + | *''Hsc82'' | ||
| + | |||
| + | **[[6xlc]] - yHsc82 + ANP<br /> | ||
| + | **[[6xlh]] - yHsc82 MD+co-chaperone AHA1 + ADP + ATPgS<br /> | ||
| + | **[[6xld]], [[6xle]], [[6xlf]] - yHsc82 MD+co-chaperone AHA1 + ANP <br /> | ||
| + | **[[6xlb]] - yHsc82 MD+co-chaperone AHA1 + ANP – Cryo EM<br /> | ||
| + | **[[6xlg]] - yHsc82 MD+co-chaperone AHA1 + ATPgS<br /> | ||
*''Hsc90'' | *''Hsc90'' | ||
Current revision
3D Structures of Heat Shock Proteins
Updated on 01-May-2023
