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8eab
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==NKG2D complexed with inhibitor 4f== | |
| - | + | <StructureSection load='8eab' size='340' side='right'caption='[[8eab]], [[Resolution|resolution]] 1.44Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8eab]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EAB FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=VN2:N-[(1S)-2-oxo-1-[3-(trifluoromethyl)phenyl]-2-({4-[4-(trifluoromethyl)phenyl]pyridin-3-yl}amino)ethyl]-4-[4-(trifluoromethyl)phenyl]pyridine-3-carboxamide'>VN2</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8eab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8eab OCA], [https://pdbe.org/8eab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8eab RCSB], [https://www.ebi.ac.uk/pdbsum/8eab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8eab ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NKG2D_HUMAN NKG2D_HUMAN] Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Grant JC]] | ||
| + | [[Category: Karpowich NK]] | ||
| + | [[Category: Sharma S]] | ||
| + | [[Category: Thompson AA]] | ||
Current revision
NKG2D complexed with inhibitor 4f
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