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4ycm

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==Crystal structure of the calcium pump with bound marine macrolide BLS==
==Crystal structure of the calcium pump with bound marine macrolide BLS==
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<StructureSection load='4ycm' size='340' side='right' caption='[[4ycm]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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<StructureSection load='4ycm' size='340' side='right'caption='[[4ycm]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4ycm]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YCM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YCM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4ycm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YCM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YCM FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7BS:(4S,5E,8S,9E,11S,13E,15E,18R)-8-METHOXY-9,11-DIMETHYL-18-[(1Z,4E)-2-METHYLHEXA-1,4-DIEN-1-YL]-2-OXOOXACYCLOOCTADECA-5,9,13,15-TETRAEN-4-YL+3-O-METHYL-BETA-D-GLUCOPYRANOSIDE'>7BS</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7BS:(4S,5E,8S,9E,11S,13E,15E,18R)-8-METHOXY-9,11-DIMETHYL-18-[(1Z,4E)-2-METHYLHEXA-1,4-DIEN-1-YL]-2-OXOOXACYCLOOCTADECA-5,9,13,15-TETRAEN-4-YL+3-O-METHYL-BETA-D-GLUCOPYRANOSIDE'>7BS</scene>, <scene name='pdbligand=AME:N-ACETYLMETHIONINE'>AME</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=AME:N-ACETYLMETHIONINE'>AME</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ycm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ycm OCA], [https://pdbe.org/4ycm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ycm RCSB], [https://www.ebi.ac.uk/pdbsum/4ycm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ycm ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ycn|4ycn]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Calcium-transporting_ATPase Calcium-transporting ATPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.3.8 3.6.3.8] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ycm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ycm OCA], [http://pdbe.org/4ycm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ycm RCSB], [http://www.ebi.ac.uk/pdbsum/4ycm PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AT2A1_RABIT AT2A1_RABIT]] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (By similarity).
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[https://www.uniprot.org/uniprot/AT2A1_RABIT AT2A1_RABIT] This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4ycm" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4ycm" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[ATPase 3D structures|ATPase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Calcium-transporting ATPase]]
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[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Morita, M]]
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[[Category: Morita M]]
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[[Category: Ogawa, H]]
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[[Category: Ogawa H]]
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[[Category: Ohno, O]]
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[[Category: Ohno O]]
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[[Category: Suenaga, K]]
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[[Category: Suenaga K]]
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[[Category: Toyoshima, C]]
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[[Category: Toyoshima C]]
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[[Category: Yamori, T]]
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[[Category: Yamori T]]
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[[Category: Ca2+]]
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[[Category: Had fold]]
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[[Category: Hydrolase]]
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[[Category: Ion pump]]
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[[Category: Membrane protein]]
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[[Category: P-type atpase]]
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Current revision

Crystal structure of the calcium pump with bound marine macrolide BLS

PDB ID 4ycm

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