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4ycz
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Y-COMPLEX HUB (NUP85-NUP120-NUP145C-SEC13 COMPLEX) FROM M. THERMOPHILA (A.K.A. T. HETEROTHALLICA)== | |
| + | <StructureSection load='4ycz' size='340' side='right'caption='[[4ycz]], [[Resolution|resolution]] 4.10Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4ycz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermothelomyces_thermophilus_ATCC_42464 Thermothelomyces thermophilus ATCC 42464]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YCZ FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ycz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ycz OCA], [https://pdbe.org/4ycz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ycz RCSB], [https://www.ebi.ac.uk/pdbsum/4ycz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ycz ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/G2QEZ2_MYCTT G2QEZ2_MYCTT] [https://www.uniprot.org/uniprot/G2QES5_MYCTT G2QES5_MYCTT] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The nuclear pore complex (NPC) is the principal gateway for transport into and out of the nucleus. Selectivity is achieved through the hydrogel-like core of the NPC. The structural integrity of the NPC depends on ~15 architectural proteins, which are organized in distinct subcomplexes to form the >40-MDa ring-like structure. Here we present the 4.1-A crystal structure of a heterotetrameric core element ('hub') of the Y complex, the essential NPC building block, from Myceliophthora thermophila. Using the hub structure together with known Y-complex fragments, we built the entire ~0.5-MDa Y complex. Our data reveal that the conserved core of the Y complex has six rather than seven members. Evolutionarily distant Y-complex assemblies share a conserved core that is very similar in shape and dimension, thus suggesting that there are closely related architectural codes for constructing the NPC in all eukaryotes. | ||
| - | + | Atomic structure of the Y complex of the nuclear pore.,Kelley K, Knockenhauer KE, Kabachinski G, Schwartz TU Nat Struct Mol Biol. 2015 Mar 30. doi: 10.1038/nsmb.2998. PMID:25822992<ref>PMID:25822992</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 4ycz" style="background-color:#fffaf0;"></div> |
| - | [[Category: Kelley | + | == References == |
| - | [[Category: Knockenhauer | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Thermothelomyces thermophilus ATCC 42464]] | ||
| + | [[Category: Kelley K]] | ||
| + | [[Category: Knockenhauer KE]] | ||
| + | [[Category: Schwartz TU]] | ||
Current revision
Y-COMPLEX HUB (NUP85-NUP120-NUP145C-SEC13 COMPLEX) FROM M. THERMOPHILA (A.K.A. T. HETEROTHALLICA)
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