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4yl0

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==Crystal Structures of mPGES-1 Inhibitor Complexes==
==Crystal Structures of mPGES-1 Inhibitor Complexes==
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<StructureSection load='4yl0' size='340' side='right' caption='[[4yl0]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
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<StructureSection load='4yl0' size='340' side='right'caption='[[4yl0]], [[Resolution|resolution]] 1.52&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4yl0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YL0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YL0 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4yl0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YL0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4DZ:2-(9-CHLORO-1H-PHENANTHRO[9,10-D]IMIDAZOL-2-YL)BENZENE-1,3-DICARBONITRILE'>4DZ</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4DZ:2-(9-CHLORO-1H-PHENANTHRO[9,10-D]IMIDAZOL-2-YL)BENZENE-1,3-DICARBONITRILE'>4DZ</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yl0 OCA], [https://pdbe.org/4yl0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yl0 RCSB], [https://www.ebi.ac.uk/pdbsum/4yl0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yl0 ProSAT]</span></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yk5|4yk5]], [[4yl1|4yl1]], [[4yl3|4yl3]]</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-E_synthase Prostaglandin-E synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.99.3 5.3.99.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yl0 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yl0 RCSB], [http://www.ebi.ac.uk/pdbsum/4yl0 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PTGES_HUMAN PTGES_HUMAN]] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).<ref>PMID:18682561</ref>
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[https://www.uniprot.org/uniprot/PTGES_HUMAN PTGES_HUMAN] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).<ref>PMID:18682561</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4yl0" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Prostaglandin E synthase|Prostaglandin E synthase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Prostaglandin-E synthase]]
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[[Category: Homo sapiens]]
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[[Category: Antonysamy, S]]
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[[Category: Large Structures]]
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[[Category: Fisher, M J]]
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[[Category: Antonysamy S]]
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[[Category: Kuklish, S L]]
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[[Category: Fisher MJ]]
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[[Category: Luz, J G]]
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[[Category: Kuklish SL]]
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[[Category: Inflammation]]
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[[Category: Luz JG]]
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[[Category: Isomerase-isomerase inhibitor complex]]
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[[Category: Prostaglandin]]
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Current revision

Crystal Structures of mPGES-1 Inhibitor Complexes

PDB ID 4yl0

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