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1hrl

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[[Image:1hrl.png|left|200px]]
 
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{{STRUCTURE_1hrl| PDB=1hrl | SCENE= }}
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==STRUCTURE OF A PARALYTIC PEPTIDE FROM AN INSECT, MANDUCA SEXTA==
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<StructureSection load='1hrl' size='340' side='right'caption='[[1hrl]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1hrl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Manduca_sexta Manduca sexta]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HRL FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hrl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hrl OCA], [https://pdbe.org/1hrl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hrl RCSB], [https://www.ebi.ac.uk/pdbsum/1hrl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hrl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PAP1_MANSE PAP1_MANSE] Causes rapid, rigid paralysis when injected into Lepidopteran larvae. The physiological role may be to reduce hemolymph loss following injury and promote wound healing.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Paralytic peptide 1 (PP1) from a moth, Manduca sexta, is a 23-residue peptide (Glu-Asn-Phe-Ala-Gly-Gly-Cys-Ala-Thr-Gly-Tyr-Leu-Arg-Thr-Ala-Asp-Gly-Arg -Cys-Lys-Pro-Thr-Phe) that was first found to have paralytic activity when injected into M. sexta larvae. Recent studies demonstrated that PP1 also stimulated the spreading and aggregation of a blood cell type called plasmatocytes and inhibited bleeding from wounds. We determined the solution structure of PP1 by two-dimensional 1H NMR spectroscopy to begin to understand structural-functional relationships of this peptide. PP1 has an ordered structure, which is composed of a short antiparallel beta-sheet at residues Tyr11-Thr14 and Arg18-Pro21, three beta turns at residues Phe3-Gly6, Ala8-Tyr11 and Thr14-Gly17, and a half turn at the carboxyl-terminus (residues Lys20-Phe23). The well-defined secondary and tertiary structure was stabilized by hydrogen bonding and side-chain hydrophobic interactions. In comparison with two related insect peptides, whose structures have been solved recently, the amino-terminal region of PP1 is substantially more ordered. The short antiparallel beta-sheet of PP1 has a folding pattern similar to the carboxyl-terminal subdomain of epidermal growth factor (EGF). Therefore, PP1 may interact with EGF receptor-like molecules to trigger its different biological activities.
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===STRUCTURE OF A PARALYTIC PEPTIDE FROM AN INSECT, MANDUCA SEXTA===
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Structure of a paralytic peptide from an insect, Manduca sexta.,Yu XQ, Prakash O, Kanost MR J Pept Res. 1999 Sep;54(3):256-61. PMID:10517164<ref>PMID:10517164</ref>
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{{ABSTRACT_PUBMED_10517164}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 1hrl" style="background-color:#fffaf0;"></div>
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[[1hrl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HRL OCA].
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== References ==
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[[Category: Kanost, M R.]]
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<references/>
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[[Category: Prakash, O.]]
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__TOC__
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[[Category: Yu, X Q.]]
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</StructureSection>
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[[Category: Enf family]]
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[[Category: Large Structures]]
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[[Category: Paralytic peptide]]
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[[Category: Manduca sexta]]
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[[Category: Plasmatocyte spreading peptide]]
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[[Category: Kanost MR]]
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[[Category: Toxin]]
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[[Category: Prakash O]]
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[[Category: Yu X-Q]]

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STRUCTURE OF A PARALYTIC PEPTIDE FROM AN INSECT, MANDUCA SEXTA

PDB ID 1hrl

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