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4yu6

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Revision as of 07:25, 10 May 2023

Crystal structure of Bacillus anthracis immune inhibitor A2 peptidase zymogen

Structural highlights

4yu6 is a 2 chain structure with sequence from Bacillus cereus biovar anthracis str. CI. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, , , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

D8H130_BACAI

Publication Abstract from PubMed

Immune inhibitor A(InhA)-type metallopeptidases are potential virulence factors secreted by members of the Bacillus cereus group. Two paralogs from anthrax-causing Bacillus anthracis (BaInhA1 and BaInhA2) were shown to degrade host tissue proteins with broad substrate specificity. Analysis of their activation mechanism and the crystal structure of a zymogenic BaInhA2 variant revealed a approximately 750-residue four-domain structure featuring a pro-peptide, a catalytic domain, a domain reminiscent of viral envelope glycoproteins, and a MAM domain grafted into the latter. This domain, previously found only in eukaryotes, is required for proper protein expression in B. anthracis and evinces certain flexibility. Latency is uniquely modulated by the N-terminal segment of the pro-peptide, which binds the catalytic zinc through its alpha-amino group and occupies the primed side of the active-site cleft. The present results further our understanding of the modus operandi of an anthrax secretome regulator.

Structural Basis for Latency and Function of Immune Inhibitor A Metallopeptidase, a Modulator of the Bacillus anthracis Secretome.,Arolas JL, Goulas T, Pomerantsev AP, Leppla SH, Gomis-Ruth FX Structure. 2016 Jan 5;24(1):25-36. doi: 10.1016/j.str.2015.10.015. PMID:26745529^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Arolas JL, Goulas T, Pomerantsev AP, Leppla SH, Gomis-Ruth FX. Structural Basis for Latency and Function of Immune Inhibitor A Metallopeptidase, a Modulator of the Bacillus anthracis Secretome. Structure. 2016 Jan 5;24(1):25-36. doi: 10.1016/j.str.2015.10.015. PMID:26745529 doi:http://dx.doi.org/10.1016/j.str.2015.10.015

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4yu6"

Categories: Bacillus cereus biovar anthracis str. CI | Large Structures | Arolas JL | Gomis-Ruth FX | Goulas T

@@ Line 3: / Line 3: @@
 <StructureSection load='4yu6' size='340' side='right'caption='[[4yu6]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4yu6]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YU6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YU6 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4yu6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_cereus_biovar_anthracis_str._CI Bacillus cereus biovar anthracis str. CI]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YU6 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yu5|4yu5]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yu6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yu6 OCA], [https://pdbe.org/4yu6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yu6 RCSB], [https://www.ebi.ac.uk/pdbsum/4yu6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yu6 ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yu6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yu6 OCA], [http://pdbe.org/4yu6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yu6 RCSB], [http://www.ebi.ac.uk/pdbsum/4yu6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yu6 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/D8H130_BACAI D8H130_BACAI]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 22: @@
 __TOC__
 </StructureSection>
+[[Category: Bacillus cereus biovar anthracis str. CI]]
 [[Category: Large Structures]]
-[[Category: Arolas, J L]]
+[[Category: Arolas JL]]
-[[Category: Gomis-Ruth, F X]]
+[[Category: Gomis-Ruth FX]]
-[[Category: Goulas, T]]
+[[Category: Goulas T]]
-[[Category: Hydrolase]]
-[[Category: Metallopeptidase]]
-[[Category: Metzincin]]

4yu6

From Proteopedia

Revision as of 07:25, 10 May 2023

Crystal structure of Bacillus anthracis immune inhibitor A2 peptidase zymogen

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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