This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


4yzs

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:33, 10 May 2023) (edit) (undo)
 
Line 3: Line 3:
<StructureSection load='4yzs' size='340' side='right'caption='[[4yzs]], [[Resolution|resolution]] 3.14&Aring;' scene=''>
<StructureSection load='4yzs' size='340' side='right'caption='[[4yzs]], [[Resolution|resolution]] 3.14&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[4yzs]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YZS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YZS FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[4yzs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YZS FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=W:TUNGSTEN+ION'>W</scene></td></tr>
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=W:TUNGSTEN+ION'>W</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yzs OCA], [https://pdbe.org/4yzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yzs RCSB], [https://www.ebi.ac.uk/pdbsum/4yzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yzs ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yzs OCA], [http://pdbe.org/4yzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4yzs RCSB], [http://www.ebi.ac.uk/pdbsum/4yzs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4yzs ProSAT]</span></td></tr>
+
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN]] Wolcott-Rallison syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10932183</ref>
+
[https://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN] Wolcott-Rallison syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:10932183</ref>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN]] Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity).
+
[https://www.uniprot.org/uniprot/E2AK3_HUMAN E2AK3_HUMAN] Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 25: Line 24:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
 +
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Non-specific serine/threonine protein kinase]]
+
[[Category: Ali MMU]]
-
[[Category: Ali, M M.U]]
+
[[Category: Carrara M]]
-
[[Category: Carrara, M]]
+
[[Category: Prischi F]]
-
[[Category: Prischi, F]]
+
-
[[Category: Er stress]]
+
-
[[Category: Perk]]
+
-
[[Category: Proteostasis]]
+
-
[[Category: Signaling protein]]
+
-
[[Category: Tetramer]]
+
-
[[Category: Unfolded protein]]
+
-
[[Category: Upr]]
+
-
[[Category: Upr activation]]
+
-
[[Category: Upr sensor]]
+

Current revision

Crystal structures reveal transient PERK luminal domain tetramerization in ER stress signaling

PDB ID 4yzs

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4yzs"
Personal tools