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4z0c

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Current revision (07:33, 10 May 2023) (edit) (undo)
 
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<StructureSection load='4z0c' size='340' side='right'caption='[[4z0c]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4z0c' size='340' side='right'caption='[[4z0c]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4z0c]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z0C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z0C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4z0c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z0C FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tlr13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z0c OCA], [https://pdbe.org/4z0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z0c RCSB], [https://www.ebi.ac.uk/pdbsum/4z0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z0c ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z0c OCA], [http://pdbe.org/4z0c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z0c RCSB], [http://www.ebi.ac.uk/pdbsum/4z0c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z0c ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TLR13_MOUSE TLR13_MOUSE]] Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Specifically binds the 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a sequence also bound by MLS group antibiotics (including erythromycin). May also recognize vesicular stomatitis virus; however, these data require additional evidences.<ref>PMID:21131352</ref> <ref>PMID:22821982</ref> <ref>PMID:22896636</ref>
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[https://www.uniprot.org/uniprot/TLR13_MOUSE TLR13_MOUSE] Component of innate and adaptive immunity that recognizes and binds 23S rRNA from bacteria. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Specifically binds the 5'-CGGAAAGACC-3' sequence on bacterial 23S rRNA, a sequence also bound by MLS group antibiotics (including erythromycin). May also recognize vesicular stomatitis virus; however, these data require additional evidences.<ref>PMID:21131352</ref> <ref>PMID:22821982</ref> <ref>PMID:22896636</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Toll-like Receptors|Toll-like Receptors]]
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*[[Toll-like Receptor 3D structures|Toll-like Receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Chai, J]]
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[[Category: Synthetic construct]]
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[[Category: Han, Z]]
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[[Category: Chai J]]
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[[Category: Song, W]]
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[[Category: Han Z]]
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[[Category: Immune receptor]]
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[[Category: Song W]]
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[[Category: Immune system]]
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[[Category: Ssrna]]
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[[Category: Toll-like receptor]]
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Current revision

Crystal structure of TLR13-ssRNA13 complex

PDB ID 4z0c

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