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4z3u

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Current revision (07:38, 10 May 2023) (edit) (undo)
 
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<StructureSection load='4z3u' size='340' side='right'caption='[[4z3u]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
<StructureSection load='4z3u' size='340' side='right'caption='[[4z3u]], [[Resolution|resolution]] 2.71&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4z3u]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Alphaherpesvirus_pseudorabies_virus_prv Alphaherpesvirus pseudorabies virus prv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z3U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z3U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4z3u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Suid_alphaherpesvirus_1 Suid alphaherpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z3U FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z3u OCA], [https://pdbe.org/4z3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z3u RCSB], [https://www.ebi.ac.uk/pdbsum/4z3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z3u ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">UL34 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10345 Alphaherpesvirus pseudorabies virus PRV]), UL31 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10345 Alphaherpesvirus pseudorabies virus PRV])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z3u OCA], [http://pdbe.org/4z3u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z3u RCSB], [http://www.ebi.ac.uk/pdbsum/4z3u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z3u ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/G3G8X8_9ALPH G3G8X8_9ALPH] Plays an essential role in virion nuclear egress, the first step of virion release from infected cell. Within the host nucleus, NEC1 interacts with the newly formed capsid through the vertexes and directs it to the inner nuclear membrane by associating with NEC2. Induces the budding of the capsid at the inner nuclear membrane as well as its envelopment into the perinuclear space. There, the NEC1/NEC2 complex promotes the fusion of the enveloped capsid with the outer nuclear membrane and the subsequent release of the viral capsid into the cytoplasm where it will reach the secondary budding sites in the host Golgi or trans-Golgi network.[HAMAP-Rule:MF_04024]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Alphaherpesvirus pseudorabies virus prv]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bigalke, J M]]
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[[Category: Suid alphaherpesvirus 1]]
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[[Category: Heldwein, E E]]
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[[Category: Bigalke JM]]
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[[Category: Complex]]
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[[Category: Heldwein EE]]
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[[Category: Membrane binding]]
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[[Category: Viral protein]]
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Current revision

PRV nuclear egress complex

PDB ID 4z3u

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