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4zet

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==Blood dendritic cell antigen 2 (BDCA-2) complexed with GalGlcNAcMan==
==Blood dendritic cell antigen 2 (BDCA-2) complexed with GalGlcNAcMan==
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<StructureSection load='4zet' size='340' side='right' caption='[[4zet]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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<StructureSection load='4zet' size='340' side='right'caption='[[4zet]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zet]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZET OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZET FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zet]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZET OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZET FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zes|4zes]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zet OCA], [https://pdbe.org/4zet PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zet RCSB], [https://www.ebi.ac.uk/pdbsum/4zet PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zet ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zet FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zet OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zet RCSB], [http://www.ebi.ac.uk/pdbsum/4zet PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CLC4C_HUMAN CLC4C_HUMAN]] Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose.<ref>PMID:11748283</ref> <ref>PMID:11031109</ref>
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[https://www.uniprot.org/uniprot/CLC4C_HUMAN CLC4C_HUMAN] Involved in antigen-capturing. Target ligand into antigen processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium. Does not seem to bind mannose.<ref>PMID:11748283</ref> <ref>PMID:11031109</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4zet" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Drickamer, K]]
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[[Category: Homo sapiens]]
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[[Category: Dungarwalla, T]]
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[[Category: Large Structures]]
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[[Category: Feinberg, H]]
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[[Category: Drickamer K]]
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[[Category: Jegouzo, S A.F]]
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[[Category: Dungarwalla T]]
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[[Category: Taylor, M E]]
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[[Category: Feinberg H]]
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[[Category: Weis, W I]]
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[[Category: Jegouzo SAF]]
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[[Category: C-type lectin]]
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[[Category: Taylor ME]]
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[[Category: Carbohydrate-binding protein]]
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[[Category: Weis WI]]

Current revision

Blood dendritic cell antigen 2 (BDCA-2) complexed with GalGlcNAcMan

PDB ID 4zet

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