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7trq
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator VU0467154== | |
| - | + | <StructureSection load='7trq' size='340' side='right'caption='[[7trq]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7trq]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TRQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TRQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IUI:5-amino-3,4-dimethyl-N-{[4-(trifluoromethanesulfonyl)phenyl]methyl}thieno[2,3-c]pyridazine-6-carboxamide'>IUI</scene>, <scene name='pdbligand=IXO:4-(4,5-DIHYDRO-1,2-OXAZOL-3-YLOXY)-N,N,N-TRIMETHYLBUT-2-YN-1-AMINIUM'>IXO</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7trq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7trq OCA], [https://pdbe.org/7trq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7trq RCSB], [https://www.ebi.ac.uk/pdbsum/7trq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7trq ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ACM4_HUMAN ACM4_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Belousoff MJ]] | ||
| + | [[Category: Danev R]] | ||
| + | [[Category: Glukhova A]] | ||
| + | [[Category: Mobbs JI]] | ||
| + | [[Category: Sexton PM]] | ||
| + | [[Category: Thal DM]] | ||
| + | [[Category: Vuckovic Z]] | ||
Current revision
Human M4 muscarinic acetylcholine receptor complex with Gi1 and the agonist iperoxo and positive allosteric modulator VU0467154
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Categories: Homo sapiens | Large Structures | Mus musculus | Belousoff MJ | Danev R | Glukhova A | Mobbs JI | Sexton PM | Thal DM | Vuckovic Z
