7zrz
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the human tRNA splicing endonuclease defines substrate recognition== | |
| - | + | <StructureSection load='7zrz' size='340' side='right'caption='[[7zrz]], [[Resolution|resolution]] 3.09Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7zrz]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZRZ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zrz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zrz OCA], [https://pdbe.org/7zrz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zrz RCSB], [https://www.ebi.ac.uk/pdbsum/7zrz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zrz ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/SEN34_HUMAN SEN34_HUMAN] Pontocerebellar hypoplasia type 2. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SEN34_HUMAN SEN34_HUMAN] Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.<ref>PMID:15109492</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Sekulovski S]] | ||
| + | [[Category: Trowitzsch S]] | ||
Revision as of 06:57, 18 May 2023
Structure of the human tRNA splicing endonuclease defines substrate recognition
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