1ktg

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[[Image:1ktg.gif|left|200px]]
[[Image:1ktg.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1ktg |SIZE=350|CAPTION= <scene name='initialview01'>1ktg</scene>, resolution 1.80&Aring;
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The line below this paragraph, containing "STRUCTURE_1ktg", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OH:HYDROXIDE+ION'>OH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Bis(5'-nucleosyl)-tetraphosphatase_(asymmetrical) Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.17 3.6.1.17] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= Y37H9A.6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6239 Caenorhabditis elegans])
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-->
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|DOMAIN=
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{{STRUCTURE_1ktg| PDB=1ktg | SCENE= }}
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|RELATEDENTRY=[[1kt9|1KT9]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ktg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktg OCA], [http://www.ebi.ac.uk/pdbsum/1ktg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ktg RCSB]</span>
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}}
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'''Crystal Structure of a C. elegans Ap4A Hydrolase Binary Complex'''
'''Crystal Structure of a C. elegans Ap4A Hydrolase Binary Complex'''
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==Reference==
==Reference==
The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms., Bailey S, Sedelnikova SE, Blackburn GM, Abdelghany HM, Baker PJ, McLennan AG, Rafferty JB, Structure. 2002 Apr;10(4):589-600. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11937063 11937063]
The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms., Bailey S, Sedelnikova SE, Blackburn GM, Abdelghany HM, Baker PJ, McLennan AG, Rafferty JB, Structure. 2002 Apr;10(4):589-600. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11937063 11937063]
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[[Category: Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)]]
 
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Rafferty, J B.]]
[[Category: Rafferty, J B.]]
[[Category: Sedelnikova, S E.]]
[[Category: Sedelnikova, S E.]]
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[[Category: amp]]
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[[Category: Amp]]
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[[Category: magnesium cluster]]
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[[Category: Magnesium cluster]]
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[[Category: nudix]]
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[[Category: Nudix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:09:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:53:19 2008''
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Revision as of 20:09, 2 May 2008

Image:1ktg.gif

Template:STRUCTURE 1ktg

Crystal Structure of a C. elegans Ap4A Hydrolase Binary Complex


Overview

The crystal structure of C. elegans Ap(4)A hydrolase has been determined for the free enzyme and a binary complex at 2.0 A and 1.8 A, respectively. Ap(4)A hydrolase has a key role in regulating the intracellular Ap(4)A levels and hence potentially the cellular response to metabolic stress and/or differentiation and apoptosis via the Ap(3)A/Ap(4)A ratio. The structures reveal that the enzyme has the mixed alpha/beta fold of the Nudix family and also show how the enzyme binds and locates its substrate with respect to the catalytic machinery of the Nudix motif. These results suggest how the enzyme can catalyze the hydrolysis of a range of related dinucleoside tetraphosphate, but not triphosphate, compounds through precise orientation of key elements of the substrate.

About this Structure

1KTG is a Single protein structure of sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA.

Reference

The crystal structure of diadenosine tetraphosphate hydrolase from Caenorhabditis elegans in free and binary complex forms., Bailey S, Sedelnikova SE, Blackburn GM, Abdelghany HM, Baker PJ, McLennan AG, Rafferty JB, Structure. 2002 Apr;10(4):589-600. PMID:11937063 Page seeded by OCA on Fri May 2 23:09:06 2008

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