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4zgq

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==Structure of Cdc123 bound to eIF2-gammaDIII domain==
==Structure of Cdc123 bound to eIF2-gammaDIII domain==
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<StructureSection load='4zgq' size='340' side='right' caption='[[4zgq]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='4zgq' size='340' side='right'caption='[[4zgq]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zgq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZGQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZGQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zgq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZGQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZGQ FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zgn|4zgn]]</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zgq OCA], [https://pdbe.org/4zgq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zgq RCSB], [https://www.ebi.ac.uk/pdbsum/4zgq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zgq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zgq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zgq OCA], [http://pdbe.org/4zgq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zgq RCSB], [http://www.ebi.ac.uk/pdbsum/4zgq PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CD123_SCHPO CD123_SCHPO]] Regulates the cell cycle in a nutrient dependent manner. [[http://www.uniprot.org/uniprot/IF2G_YEAST IF2G_YEAST]] eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.
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[https://www.uniprot.org/uniprot/CD123_SCHPO CD123_SCHPO] Regulates the cell cycle in a nutrient dependent manner.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4zgq" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4zgq" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arnold, L]]
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[[Category: Large Structures]]
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[[Category: Dubiez, E]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Mechulam, Y]]
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[[Category: Schizosaccharomyces pombe]]
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[[Category: Panvert, M]]
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[[Category: Arnold L]]
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[[Category: Perez, J]]
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[[Category: Dubiez E]]
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[[Category: Schmitt, E]]
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[[Category: Mechulam Y]]
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[[Category: Seufert, W]]
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[[Category: Panvert M]]
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[[Category: Atp-grasp fold]]
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[[Category: Perez J]]
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[[Category: Cell cycle]]
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[[Category: Schmitt E]]
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[[Category: Eif2]]
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[[Category: Seufert W]]

Current revision

Structure of Cdc123 bound to eIF2-gammaDIII domain

PDB ID 4zgq

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