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4zi9

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Revision as of 07:28, 18 May 2023

Structure of mouse clustered PcdhgA1 EC1-3

Structural highlights

4zi9 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

Q91XZ0_MOUSE Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.[SAAS:SAAS00311819]

Publication Abstract from PubMed

Clustered protocadherin (Pcdh) proteins mediate dendritic self-avoidance in neurons via specific homophilic interactions in their extracellular cadherin (EC) domains. We determined crystal structures of EC1-EC3, containing the homophilic specificity-determining region, of two mouse clustered Pcdh isoforms (PcdhgammaA1 and PcdhgammaC3) to investigate the nature of the homophilic interaction. Within the crystal lattices, we observe antiparallel interfaces consistent with a role in trans cell-cell contact. Antiparallel dimerization is supported by evolutionary correlations. Two interfaces, located primarily on EC2-EC3, involve distinctive clustered Pcdh structure and sequence motifs, lack predicted glycosylation sites, and contain residues highly conserved in orthologs but not paralogs, pointing toward their biological significance as homophilic interaction interfaces. These two interfaces are similar yet distinct, reflecting a possible difference in interaction architecture between clustered Pcdh subfamilies. These structures initiate a molecular understanding of clustered Pcdh assemblies that are required to produce functional neuronal networks.

Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity.,Nicoludis JM, Lau SY, Scharfe CP, Marks DS, Weihofen WA, Gaudet R Structure. 2015 Nov 3;23(11):2087-98. doi: 10.1016/j.str.2015.09.005. Epub 2015, Oct 15. PMID:26481813^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Nicoludis JM, Lau SY, Scharfe CP, Marks DS, Weihofen WA, Gaudet R. Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity. Structure. 2015 Nov 3;23(11):2087-98. doi: 10.1016/j.str.2015.09.005. Epub 2015, Oct 15. PMID:26481813 doi:http://dx.doi.org/10.1016/j.str.2015.09.005

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4zi9"

@@ Line 3: / Line 3: @@
 <StructureSection load='4zi9' size='340' side='right'caption='[[4zi9]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[4zi9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZI9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZI9 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[4zi9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZI9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZI9 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zi8|4zi8]]</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zi9 OCA], [https://pdbe.org/4zi9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zi9 RCSB], [https://www.ebi.ac.uk/pdbsum/4zi9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zi9 ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Pcdhga1, mCG_133388 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zi9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zi9 OCA], [http://pdbe.org/4zi9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zi9 RCSB], [http://www.ebi.ac.uk/pdbsum/4zi9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zi9 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/Q91XZ0_MOUSE Q91XZ0_MOUSE]] Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.[SAAS:SAAS00311819]
+[https://www.uniprot.org/uniprot/Q91XZ0_MOUSE Q91XZ0_MOUSE] Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.[SAAS:SAAS00311819]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 25: / Line 23: @@
 </StructureSection>
 [[Category: Large Structures]]
-[[Category: Lk3 transgenic mice]]
+[[Category: Mus musculus]]
-[[Category: Gaudet, R]]
+[[Category: Gaudet R]]
-[[Category: Lau, S Y]]
+[[Category: Lau S-Y]]
-[[Category: Marks, D S]]
+[[Category: Marks DS]]
-[[Category: Nicoludis, J M]]
+[[Category: Nicoludis JM]]
-[[Category: Scharfe, C P.I]]
+[[Category: Scharfe CPI]]
-[[Category: Weihofen, W A]]
+[[Category: Weihofen WA]]
-[[Category: Cell adhesion]]
-[[Category: Complex]]
-[[Category: Membrane protein]]
-[[Category: Protocadherin]]

4zi9

From Proteopedia

Revision as of 07:28, 18 May 2023

Structure of mouse clustered PcdhgA1 EC1-3

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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