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| | ==Psoriasis pathogenesis - Pso p27 constitute a compact structure forming large aggregates. Low pH structure== | | ==Psoriasis pathogenesis - Pso p27 constitute a compact structure forming large aggregates. Low pH structure== |
| - | <StructureSection load='4zk3' size='340' side='right' caption='[[4zk3]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='4zk3' size='340' side='right'caption='[[4zk3]], [[Resolution|resolution]] 2.00Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[4zk3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZK3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZK3 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[4zk3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZK3 FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zk0|4zk0]]</td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zk3 OCA], [https://pdbe.org/4zk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zk3 RCSB], [https://www.ebi.ac.uk/pdbsum/4zk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zk3 ProSAT]</span></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SERPINB3, SCCA, SCCA1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zk3 OCA], [http://pdbe.org/4zk3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zk3 RCSB], [http://www.ebi.ac.uk/pdbsum/4zk3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zk3 ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/SPB3_HUMAN SPB3_HUMAN]] May act as a protease inhibitor to modulate the host immune response against tumor cells. | + | [https://www.uniprot.org/uniprot/SPB3_HUMAN SPB3_HUMAN] May act as a protease inhibitor to modulate the host immune response against tumor cells. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | ==See Also== | | ==See Also== |
| - | *[[Serpin|Serpin]] | + | *[[Serpin 3D structures|Serpin 3D structures]] |
| | == References == | | == References == |
| | <references/> | | <references/> |
| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| - | [[Category: Helland, R]] | + | [[Category: Large Structures]] |
| - | [[Category: Iversen, O J]] | + | [[Category: Helland R]] |
| - | [[Category: Lysvand, H]] | + | [[Category: Iversen OJ]] |
| - | [[Category: Slupphaug, G]] | + | [[Category: Lysvand H]] |
| - | [[Category: Autoimmunity]]
| + | [[Category: Slupphaug G]] |
| - | [[Category: Hydrolase inhibitor]]
| + | |
| - | [[Category: Immune system]]
| + | |
| - | [[Category: Pathogenesis]]
| + | |
| - | [[Category: Pso p27]]
| + | |
| - | [[Category: Pso p27-complex]]
| + | |
| - | [[Category: Psoriasis]]
| + | |
| - | [[Category: Scca1]]
| + | |
| - | [[Category: Serpinb3]]
| + | |
| Structural highlights
Function
SPB3_HUMAN May act as a protease inhibitor to modulate the host immune response against tumor cells.
Publication Abstract from PubMed
Psoriasis is a chronic inflammatory skin disease. The absence of microbial organisms as potential causal agents has given rise to the hypothesis that the inflammation is due to an autoimmune reaction. The defined inflamed areas of the skin lesions argue for an immunological disease with a local production of a causal antigen. Pso p27 is a protein generated in mast cells in psoriatic plaques, but not in uninvolved skin. We recently demonstrated that the Pso p27 is generated by cleavage of SerpinB3 (SCCA1) in the presence of mast cell associated chymase. In this communication we demonstrate by X-ray crystallographic analysis that the cleavage products associate into a complex similar to SCCA1, but with the reactive centre loop inserted into a 5-stranded central beta-sheet. Native gel electrophoresis show that these Pso p27 complexes form large aggregates which may be of significance with respect to an immunogenic role of Pso p27.
Psoriasis pathogenesis - Pso p27 constitutes a compact structure forming large aggregates.,Lysvand H, Helland R, Hagen L, Slupphaug G, Iversen OJ Biochem Biophys Rep. 2015 Jun 9;2:132-136. doi: 10.1016/j.bbrep.2015.06.001., eCollection 2015 Jul. PMID:29124154[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Lysvand H, Helland R, Hagen L, Slupphaug G, Iversen OJ. Psoriasis pathogenesis - Pso p27 constitutes a compact structure forming large aggregates. Biochem Biophys Rep. 2015 Jun 9;2:132-136. doi: 10.1016/j.bbrep.2015.06.001., eCollection 2015 Jul. PMID:29124154 doi:http://dx.doi.org/10.1016/j.bbrep.2015.06.001
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