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4zs7
From Proteopedia
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==Structural mimicry of receptor interaction by antagonistic IL-6 antibodies== | ==Structural mimicry of receptor interaction by antagonistic IL-6 antibodies== | ||
| - | <StructureSection load='4zs7' size='340' side='right' caption='[[4zs7]], [[Resolution|resolution]] 2.93Å' scene=''> | + | <StructureSection load='4zs7' size='340' side='right'caption='[[4zs7]], [[Resolution|resolution]] 2.93Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4zs7]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZS7 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4zs7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZS7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZS7 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zs7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zs7 OCA], [https://pdbe.org/4zs7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zs7 RCSB], [https://www.ebi.ac.uk/pdbsum/4zs7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zs7 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN] Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ) [MIM:[https://omim.org/entry/604302 604302]. An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. Note=A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/IL6_HUMAN IL6_HUMAN] Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4zs7" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4zs7" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Interleukin 3D structures|Interleukin 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Lama glama]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Blanchetot C]] |
| - | [[Category: | + | [[Category: Cambillau C]] |
| - | + | [[Category: De Jonge N]] | |
| - | [[Category: Jonge | + | [[Category: Desmyter A]] |
| - | [[Category: | + | [[Category: Hofman E]] |
| - | [[Category: | + | [[Category: Hultberg A]] |
| - | [[Category: | + | [[Category: Klarenbeek A]] |
| - | [[Category: | + | [[Category: Kretz-Rommel A]] |
| - | [[Category: | + | [[Category: Loris R]] |
| - | [[Category: | + | [[Category: Ongenae N]] |
| - | [[Category: | + | [[Category: Sadi A]] |
| - | [[Category: | + | [[Category: Spinelli S]] |
| - | [[Category: | + | [[Category: De Haard H]] |
| - | [[Category: | + | |
Current revision
Structural mimicry of receptor interaction by antagonistic IL-6 antibodies
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Categories: Homo sapiens | Lama glama | Large Structures | Blanchetot C | Cambillau C | De Jonge N | Desmyter A | Hofman E | Hultberg A | Klarenbeek A | Kretz-Rommel A | Loris R | Ongenae N | Sadi A | Spinelli S | De Haard H
