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7y1f

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(New page: '''Unreleased structure''' The entry 7y1f is ON HOLD Authors: Chen, B.O., Xu, F.Ei. Description: KOR COMPLEX Category: Unreleased Structures Category: Chen, B.O [[Category: Xu,...)
Current revision (03:58, 25 May 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7y1f is ON HOLD
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==Cryo-EM structure of human k-opioid receptor-Gi complex==
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<StructureSection load='7y1f' size='340' side='right'caption='[[7y1f]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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Authors: Chen, B.O., Xu, F.Ei.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7y1f]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Y1F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Y1F FirstGlance]. <br>
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Description: KOR COMPLEX
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7y1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7y1f OCA], [https://pdbe.org/7y1f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7y1f RCSB], [https://www.ebi.ac.uk/pdbsum/7y1f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7y1f ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Chen, B.O]]
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== Function ==
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[[Category: Xu, F.Ei]]
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[https://www.uniprot.org/uniprot/OPRK_HUMAN OPRK_HUMAN] G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.<ref>PMID:12004055</ref> <ref>PMID:22437504</ref> <ref>PMID:7624359</ref> <ref>PMID:8060324</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Chen BO]]
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[[Category: Xu FE]]

Current revision

Cryo-EM structure of human k-opioid receptor-Gi complex

PDB ID 7y1f

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