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8sf0
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo-EM Structure of RyR1 + cAMP (Local Refinement of TMD)== | |
| - | + | <StructureSection load='8sf0' size='340' side='right'caption='[[8sf0]], [[Resolution|resolution]] 2.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8sf0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SF0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SF0 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8sf0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8sf0 OCA], [https://pdbe.org/8sf0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8sf0 RCSB], [https://www.ebi.ac.uk/pdbsum/8sf0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8sf0 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Oryctolagus cuniculus]] | ||
| + | [[Category: Berezuk AM]] | ||
| + | [[Category: Cholak S]] | ||
| + | [[Category: Haji-Ghassemi O]] | ||
| + | [[Category: Saville JW]] | ||
| + | [[Category: Subramaniam S]] | ||
| + | [[Category: Tuttle KS]] | ||
| + | [[Category: Van Petegem F]] | ||
| + | [[Category: Zhu X]] | ||
Revision as of 04:09, 25 May 2023
Cryo-EM Structure of RyR1 + cAMP (Local Refinement of TMD)
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