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5a2q
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5a2q is ON HOLD until sometime in the future Authors: Quade, N., Leiundgut, M., Boehringer, D., Heuvel, J.v.d., Ban, N. Description: Structure of t...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the HCV IRES bound to the human ribosome== | |
| + | <SX load='5a2q' size='340' side='right' viewer='molstar' caption='[[5a2q]], [[Resolution|resolution]] 3.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5a2q]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Hepacivirus_C Hepacivirus C] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A2Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A2Q FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a2q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a2q OCA], [https://pdbe.org/5a2q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a2q RCSB], [https://www.ebi.ac.uk/pdbsum/5a2q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a2q ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RS2_HUMAN RS2_HUMAN] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Hepatitis C virus (HCV), a widespread human pathogen, is dependent on a highly structured 5'-untranslated region of its mRNA, referred to as internal ribosome entry site (IRES), for the translation of all of its proteins. The HCV IRES initiates translation by directly binding to the small ribosomal subunit (40S), circumventing the need for many eukaryotic translation initiation factors required for mRNA scanning. Here we present the cryo-EM structure of the human 40S ribosomal subunit in complex with the HCV IRES at 3.9 A resolution, determined by focused refinement of an 80S ribosome-HCV IRES complex. The structure reveals the molecular details of the interactions between the IRES and the 40S, showing that expansion segment 7 (ES7) of the 18S rRNA acts as a central anchor point for the HCV IRES. The structural data rationalizes previous biochemical and genetic evidence regarding the initiation mechanism of the HCV and other related IRESs. | ||
| - | + | Cryo-EM structure of Hepatitis C virus IRES bound to the human ribosome at 3.9-A resolution.,Quade N, Boehringer D, Leibundgut M, van den Heuvel J, Ban N Nat Commun. 2015 Jul 8;6:7646. doi: 10.1038/ncomms8646. PMID:26155016<ref>PMID:26155016</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5a2q" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | |
| - | [[Category: Boehringer | + | ==See Also== |
| - | [[Category: Leiundgut | + | *[[3D sructureseceptor for activated protein kinase C 1|3D sructureseceptor for activated protein kinase C 1]] |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </SX> | ||
| + | [[Category: Hepacivirus C]] | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ban N]] | ||
| + | [[Category: Boehringer D]] | ||
| + | [[Category: Heuvel Jvd]] | ||
| + | [[Category: Leiundgut M]] | ||
| + | [[Category: Quade N]] | ||
Current revision
Structure of the HCV IRES bound to the human ribosome
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