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5aa0

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'''Unreleased structure'''
 
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The entry 5aa0 is ON HOLD
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==Complex of Thermous thermophilus ribosome (A-and P-site tRNA) bound to BipA-GDPCP==
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<SX load='5aa0' size='340' side='right' viewer='molstar' caption='[[5aa0]], [[Resolution|resolution]] 5.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5aa0]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AA0 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8AN:3-AMINO-3-DEOXYADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>8AN</scene>, <scene name='pdbligand=GCP:PHOSPHOMETHYLPHOSPHONIC+ACID+GUANYLATE+ESTER'>GCP</scene>, <scene name='pdbligand=NMY:NEOMYCIN'>NMY</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aa0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aa0 OCA], [https://pdbe.org/5aa0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aa0 RCSB], [https://www.ebi.ac.uk/pdbsum/5aa0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aa0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL3_THET8 RL3_THET8] One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity).[HAMAP-Rule:MF_01325_B]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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BPI-inducible protein A (BipA) is a member of the family of ribosome-dependent translational GTPase (trGTPase) factors along with elongation factors G and 4 (EF-G and EF4). Despite being highly conserved in bacteria and playing a critical role in coordinating cellular responses to environmental changes, its structures (isolated and ribosome bound) remain elusive. Here, we present the crystal structures of apo form and GTP analog, GDP, and guanosine-3',5'-bisdiphosphate (ppGpp)-bound BipA. In addition to having a distinctive domain arrangement, the C-terminal domain of BipA has a unique fold. Furthermore, we report the cryo-electron microscopy structure of BipA bound to the ribosome in its active GTP form and elucidate the unique structural attributes of BipA interactions with the ribosome and A-site tRNA in the light of its possible function in regulating translation.
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Authors: Kumar, V., Chen, Y., Ahmed, T., Tan, J., Ero, R., Bhushan, S., Gao, Y.-G.
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Structure of BipA in GTP form bound to the ratcheted ribosome.,Kumar V, Chen Y, Ero R, Ahmed T, Tan J, Li Z, Wong AS, Bhushan S, Gao YG Proc Natl Acad Sci U S A. 2015 Aug 17. pii: 201513216. PMID:26283392<ref>PMID:26283392</ref>
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Description: Complex of Thermous thermophilus ribosome (A-and P-site tRNA) to bound BipA-GDPCP
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Kumar, V]]
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<div class="pdbe-citations 5aa0" style="background-color:#fffaf0;"></div>
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[[Category: Gao, Y.-G]]
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[[Category: Chen, Y]]
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==See Also==
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[[Category: Tan, J]]
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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[[Category: Ero, R]]
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*[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]]
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[[Category: Ahmed, T]]
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== References ==
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[[Category: Bhushan, S]]
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<references/>
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__TOC__
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</SX>
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[[Category: Large Structures]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Ahmed T]]
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[[Category: Bhushan S]]
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[[Category: Chen Y]]
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[[Category: Ero R]]
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[[Category: Gao Y-G]]
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[[Category: Kumar V]]
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[[Category: Tan J]]

Current revision

Complex of Thermous thermophilus ribosome (A-and P-site tRNA) bound to BipA-GDPCP

5aa0, resolution 5.00Å

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