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5afb

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==Crystal structure of the Latrophilin3 Lectin and Olfactomedin Domains==
==Crystal structure of the Latrophilin3 Lectin and Olfactomedin Domains==
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<StructureSection load='5afb' size='340' side='right' caption='[[5afb]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
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<StructureSection load='5afb' size='340' side='right'caption='[[5afb]], [[Resolution|resolution]] 2.16&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5afb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AFB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AFB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5afb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AFB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AFB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5afb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5afb OCA], [http://pdbe.org/5afb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5afb RCSB], [http://www.ebi.ac.uk/pdbsum/5afb PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5afb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5afb OCA], [https://pdbe.org/5afb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5afb RCSB], [https://www.ebi.ac.uk/pdbsum/5afb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5afb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/AGRL3_MOUSE AGRL3_MOUSE]] Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:22405201, PubMed:25728924, PubMed:26235031). Plays a role in the development of glutamatergic synapses in the cortex (PubMed:22405201, PubMed:24739570). Important in determining the connectivity rates between the principal neurons in the cortex (PubMed:24739570).<ref>PMID:22405201</ref> <ref>PMID:24739570</ref> <ref>PMID:25728924</ref> <ref>PMID:26235031</ref>
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[https://www.uniprot.org/uniprot/AGRL3_HUMAN AGRL3_HUMAN] Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells (PubMed:26235030). Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex.[UniProtKB:Q80TS3]<ref>PMID:26235030</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5afb" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5afb" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Latrophilin|Latrophilin]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Carrasquero, M]]
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[[Category: Homo sapiens]]
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[[Category: Harlos, K]]
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[[Category: Large Structures]]
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[[Category: Jackson, V A]]
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[[Category: Carrasquero M]]
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[[Category: Klein, R]]
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[[Category: Harlos K]]
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[[Category: Roversi, P]]
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[[Category: Jackson VA]]
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[[Category: Seiradake, E]]
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[[Category: Klein R]]
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[[Category: Toro, D del]]
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[[Category: Roversi P]]
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[[Category: Adhesion]]
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[[Category: Seiradake E]]
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[[Category: Beta propeller]]
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[[Category: Del Toro D]]
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[[Category: Guidance]]
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[[Category: Lectin]]
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[[Category: Olfactomedin]]
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[[Category: Repulsion]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of the Latrophilin3 Lectin and Olfactomedin Domains

PDB ID 5afb

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