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5aj8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Tubulin Binding Cofactor C from Leishmania major== | |
| + | <StructureSection load='5aj8' size='340' side='right'caption='[[5aj8]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5aj8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AJ8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aj8 OCA], [https://pdbe.org/5aj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aj8 RCSB], [https://www.ebi.ac.uk/pdbsum/5aj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aj8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q4Q1A3_LEIMA Q4Q1A3_LEIMA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Tubulin-binding cofactor C stimulates GTPase activity and contributes to the release of the heterodimeric alpha/#XPiS#betaetalpha;-tubulin from a super-complex of tubulin monomers and two ancillary cofactors. We have determined the 2.2 A resolution crystal structure of the C-terminal domain of tubulin-binding cofactor C from Leishmania major based on single wavelength anomalous dispersion measurements targeting a selenomethionine derivative. Although previously predicted to consist of two domains the structure is best described as a single domain dominated by a right-handed beta-helix of five turns that form a triangular prism. One face of the prism is covered by the C-terminal residues leaving another face solvent exposed. Comparisons with an orthologous human GTPase activating protein match key residues involved in binding nucleotide and identify the face of the beta-helix fold likely involved in interacting with the beta-tubulin:GTP complex. | ||
| - | + | Crystal structure of the C-terminal domain of tubulin-binding cofactor C from Leishmania major.,Barrack KL, Fyfe PK, Finney AJ, Hunter WN Mol Biochem Parasitol. 2015 May 14. pii: S0166-6851(15)30002-5. doi:, 10.1016/j.molbiopara.2015.05.003. PMID:25982270<ref>PMID:25982270</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5aj8" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Leishmania major]] | ||
| + | [[Category: Barrack KL]] | ||
| + | [[Category: Finney AJ]] | ||
| + | [[Category: Fyfe PK]] | ||
| + | [[Category: Hunter WN]] | ||
Current revision
Tubulin Binding Cofactor C from Leishmania major
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