Indole-3-glycerol phosphate synthase

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<StructureSection load='1a53' size='350' side='right' caption='Structure of IGPS complex with IGP (PDB entry [[1a53]])' scene=''>
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<StructureSection load='' size='350' side='right' caption='Structure of IGPS complex with IGP (PDB entry [[1a53]])' scene='57/572309/Cv/1'>
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== Function ==
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'''Indole-3-glycerol phosphate synthase''' (IGPS) catalyzes the reversible transformation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (CDRP) to 1-C-(indol-e-yl)-glycerol 3-phosphate (IGP), CO2 and H2O. IGPS is part of the tryptophan biosynthesis.
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'''Indole-3-glycerol phosphate synthase''' or '''imidazole glycerol phosphate synthase''' (IGPS) catalyzes the reversible transformation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (CdRP) to 1-C-(indol-e-yl)-glycerol 3-phosphate (IGP), CO2 and H2O. IGPS is part of the tryptophan biosynthesis<ref>PMID:5332729</ref>.
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== Structural highlights ==
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The <scene name='57/572309/Cv/6'>active site of IGPS containing the reaction product IGP</scene><ref>PMID:12054868</ref>. Water molecules shown as red spheres.
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</StructureSection>
==3D structures of IGPS==
==3D structures of IGPS==
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[[IGPS 3D structures]]
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[[1igs]], [[3tc6]], [[3tc7]] – SsIGPS + PO4 – ''Sulfolobus solfataricus'' <br />
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== References ==
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[[1juk]], [[2c3z]], [[3nyz]] – SsIGPS + SO4 <br />
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<references/>
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[[4iww]] – SsIGPS (mutant) + SO4 + Co<br />
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[[4ix0]] – SsIGPS (mutant) + SO4 + Ni<br />
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[[1jul]] – SsIGPS <br />
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[[1i4n]] – TmIGPS + SO4 – ''Thermotoga maritima''<br />
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[[1j5t]] – TmIGPS <br />
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[[1vc4]] – IGPS + SO4 – ''Thermus thermophilus''<br />
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[[3qja]] – MtGPS + SO4 – ''Mycobacterium tuberculosis''<br />
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[[4fb7]] – MtIGPS <br />
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[[3tsm]] – IGPS + SO4 – ''Brucella melitensis''<br />
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===IGPS complex with reactants or derivatives===
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[[1a53]] – SsIGPS + IGP <br />
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[[1lbf]], [[1lbl]] – SsIGPS + CDRP <br />
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[[3nz1]] – SsIGPS (mutant) + SO4 + transition state analog<br />
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[[3t40]] – MtIGPS + CPG <br />
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[[3t44]] – MtIGPS + IGP + anthranilate<br />
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[[3t55]] – MtIGPS + PMBA <br />
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[[3t78]] – MtIGPS + fluoroanthranilate<br />
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[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Structure of IGPS complex with IGP (PDB entry 1a53)

Drag the structure with the mouse to rotate

3D structures of IGPS

IGPS 3D structures

References

  1. ↑ Creighton TE, Yanofsky C. Indole-3-glycerol phosphate synthetase of Escherichia coli, an enzyme of the tryptophan operon. J Biol Chem. 1966 Oct 25;241(20):4616-24. PMID:5332729
  2. ↑ Hennig M, Darimont BD, Jansonius JN, Kirschner K. The catalytic mechanism of indole-3-glycerol phosphate synthase: crystal structures of complexes of the enzyme from Sulfolobus solfataricus with substrate analogue, substrate, and product. J Mol Biol. 2002 Jun 7;319(3):757-66. PMID:12054868 doi:http://dx.doi.org/10.1016/S0022-2836(02)00378-9

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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