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Insulin 3D Structures
From Proteopedia
(Difference between revisions)
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(Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}) | (Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}) | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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* Insulin | * Insulin | ||
| - | **[[5bts]], [[4ak0]], [[2lgb]], [[1guj]], [[2c8r]], [[2c8q]], [[3i40]], [[3i3z]], [[5en9]], [[3zi3]] - hIns A chain + B chain – human<br /> | + | **[[5bts]], [[4ak0]], [[2lgb]], [[1guj]], [[2c8r]], [[2c8q]], [[3i40]], [[3i3z]], [[5en9]], [[3zi3]], [[6s34]], [[6h3m]], [[6o17]], [[6s34]], [[7ac4]], [[7jp3]], [[7qgf]], [[7s4y]], [[7z5l]], [[7z5q]], [[8gsg]] - hIns A chain + B chain – human<br /> |
| - | **[[3e7y]], [[3e7z]], [[2qiu]], [[1os3]], [[1os4]], [[1mso]], [[1g7a]], [[1g7b]], [[1trz]], [[4eww]], [[4ewx]], [[4ewz]], [[4ex0]], [[4ex1]], [[4exx]], [[4ey1]], [[4ey9]], [[4eyd]], [[4eyn]], [[4eyp]], [[4f0n]], [[4f0o]], [[4f1a]], [[4f1b]], [[4f1c]] [[4f1d]], [[4f1f]], [[4f1g]], [[4f4t]], [[4f4v]], [[4f51]], [[4f8f]], [[4fg3]], [[4p65]], [[2vjz]], [[2vk0]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]], [[5ems]], [[5e7w]], [[5co9]], [[5co6]], [[5co2]] - hIns A chain + B chain + Zn<br /> | + | **[[6jr3]] - hIns A chain + B chain – Cryo EM<br /> |
| + | **[[3e7y]], [[3e7z]], [[2qiu]], [[1os3]], [[1os4]], [[1mso]], [[1g7a]], [[1g7b]], [[1trz]], [[4eww]], [[4ewx]], [[4ewz]], [[4ex0]], [[4ex1]], [[4exx]], [[4ey1]], [[4ey9]], [[4eyd]], [[4eyn]], [[4eyp]], [[4f0n]], [[4f0o]], [[4f1a]], [[4f1b]], [[4f1c]] [[4f1d]], [[4f1f]], [[4f1g]], [[4f4t]], [[4f4v]], [[4f51]], [[4f8f]], [[4fg3]], [[4p65]], [[2vjz]], [[2vk0]], [[3p33]], [[3w7y]], [[3w7z]], [[3w80]], [[5ems]], [[5e7w]], [[5co9]], [[5co6]], [[5co2]], [[6gv0]], [[6zi8]] - hIns A chain + B chain + Zn<br /> | ||
**[[1fu2]], [[1fub]] - hIns A chain + B chain + Zn – powder diffraction<br /> | **[[1fu2]], [[1fub]] - hIns A chain + B chain + Zn – powder diffraction<br /> | ||
**[[5t7r]] - hIns A chain (mutant) + B chain<br /> | **[[5t7r]] - hIns A chain (mutant) + B chain<br /> | ||
| - | **[[1b9e]], [[3u4n]], [[4iuz]], [[4une]], [[4ung]], [[4unh]] - hIns A chain + B chain (mutant)<br /> | + | **[[1b9e]], [[3u4n]], [[4iuz]], [[4une]], [[4ung]], [[4unh]], [[5ena]], [[2ws4]], [[7nhu]] - hIns A chain + B chain (mutant)<br /> |
| - | **[[3bxq]], [[1qj0]] – hIns A chain + B chain (mutant) + Zn | + | **[[3bxq]], [[1qj0]], [[6tyh]] – hIns A chain + B chain (mutant) + Zn<br /> |
| - | **[[3ir0]], [[3inc]], [[3ilg]], [[3exx]], [[2r34]], [[2r35]], [[2r36]], [[3tt8]], [[4rxw]], [[4fka]] - hIns A chain + B chain + non-Zn metal ion<br /> | + | **[[3ir0]], [[3inc]], [[3ilg]], [[3exx]], [[2r34]], [[2r35]], [[2r36]], [[3tt8]], [[4rxw]], [[4fka]], [[6p4z]] - hIns A chain + B chain + non-Zn metal ion<br /> |
**[[1jca]], [[1j73]], [[4efx]], - hIns A chain (mutant) + B chain + Zn<br /> | **[[1jca]], [[1j73]], [[4efx]], - hIns A chain (mutant) + B chain + Zn<br /> | ||
| - | **[[ | + | **[[5mwq]], [[5azz]], [[6s4i]], [[6s4j]], [[6vet]] - hIns A chain (mutant) + B chain (mutant)<br /> |
| - | **[[ | + | **[[6p4z]] - hIns A chain + B chain + Co + Gd<br /> |
**[[2g4m]], [[9ins]], [[3t2a]], [[4a7e]], [[5lis]], [[5fb6]], [[5d5e]], [[5d54]], [[5d53]], [[5d52]] - pIns A chain + B chain – pig<br /> | **[[2g4m]], [[9ins]], [[3t2a]], [[4a7e]], [[5lis]], [[5fb6]], [[5d5e]], [[5d54]], [[5d53]], [[5d52]] - pIns A chain + B chain – pig<br /> | ||
**[[1iza]] - pIns A chain + B chain (mutant)<br /> | **[[1iza]] - pIns A chain + B chain (mutant)<br /> | ||
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**[[1m5a]] - pIns A chain + B chain + Co<br /> | **[[1m5a]] - pIns A chain + B chain + Co<br /> | ||
**[[6ins]] – pIns single chain<br /> | **[[6ins]] – pIns single chain<br /> | ||
| - | **[[1aph]], [[1bph]], [[1cph]], [[1dph]], [[4bs3]], [[4i5y]], [[4i5z]], [[4ihn]], [[2bn1]], [[2bn3]] - bIns A chain + B chain – bovine<br /> | + | **[[1aph]], [[1bph]], [[1cph]], [[1dph]], [[4bs3]], [[4i5y]], [[4i5z]], [[4ihn]], [[2bn1]], [[2bn3]], [[6or0]], [[6qq7]], [[6qqg]], [[6qrh]], [[6qrk]] - bIns A chain + B chain – bovine<br /> |
**[[2zp6]], [[4e7t]], [[4e7u]], [[4e7v]], [[4idw]], [[2a3g]], - bIns A chain + B chain + Zn <br /> | **[[2zp6]], [[4e7t]], [[4e7u]], [[4e7v]], [[4idw]], [[2a3g]], - bIns A chain + B chain + Zn <br /> | ||
| + | **[[6zhb]] - bIns A chain + B chain + Zn – electron diffraction<br /> | ||
**[[4m4f]], [[4m4h]], [[4m4i]], [[4m4j]], [[4m4l]], [[4m4m]] - bIns A chain + B chain + non-Zn metal ion<br /> | **[[4m4f]], [[4m4h]], [[4m4i]], [[4m4j]], [[4m4l]], [[4m4m]] - bIns A chain + B chain + non-Zn metal ion<br /> | ||
| + | **[[6q8q]] - bIns A chain + B chain + Ar <br /> | ||
| - | Insulin structures using NMR | + | *Insulin structures using NMR |
| - | **[[1sf1]], [[2aiy]], [[3aiy]], [[4aiy]], [[5aiy]], [[1xgl]], [[2mvc]], [[2kxk]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]], [[2hiu]], [[2jv1]] - hIns A chain + B chain – NMR<br /> | + | **[[1sf1]], [[2aiy]], [[3aiy]], [[4aiy]], [[5aiy]], [[1xgl]], [[2mvc]], [[2kxk]], [[2m1e]], [[2m2m]], [[2m2n]], [[2m2o]], [[2m2p]], [[2hiu]], [[2jv1]], [[6x4x]] - hIns A chain + B chain – NMR<br /> |
**[[1ai0]], [[1aiy]] - hIns A chain + B chain + Zn – NMR<br /> | **[[1ai0]], [[1aiy]] - hIns A chain + B chain + Zn – NMR<br /> | ||
**[[1t1k]], [[1t1p]], [[1t1q]], [[2mpg]], [[2mpi]], [[2l1z]], [[5mhd]] - hIns A chain (mutant) + B chain – NMR<br /> | **[[1t1k]], [[1t1p]], [[1t1q]], [[2mpg]], [[2mpi]], [[2l1z]], [[5mhd]] - hIns A chain (mutant) + B chain – NMR<br /> | ||
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**[[2kqq]], [[2l1y]] - hIns A chain (mutant) + B chain + Ala – NMR<br /> | **[[2kqq]], [[2l1y]] - hIns A chain (mutant) + B chain + Ala – NMR<br /> | ||
**[[2kjr]] - hIns A chain + B chain (mutant) + Ala – NMR<br /> | **[[2kjr]] - hIns A chain + B chain (mutant) + Ala – NMR<br /> | ||
| + | **[[7elj]] - bIns A chain + B chain + tetrapeptide – NMR<br /> | ||
**[[2hh4]] - hIns A chain + B chain (mutant) + Ser – NMR<br /> | **[[2hh4]] - hIns A chain + B chain (mutant) + Ser – NMR<br /> | ||
**[[2kju]] - hIns A chain + B chain (mutant) + Glu – NMR<br /> | **[[2kju]] - hIns A chain + B chain (mutant) + Glu – NMR<br /> | ||
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**[[2jzq]] – hIns single chain (mutant) - NMR<br /> | **[[2jzq]] – hIns single chain (mutant) - NMR<br /> | ||
**[[1ho0]] - bIns B chain (mutant) – NMR<br /> | **[[1ho0]] - bIns B chain (mutant) – NMR<br /> | ||
| - | **[[5miz]] - bIns A chain + B chain – NMR<br /> | + | **[[5miz]], [[6kh8]], [[6kh9]], [[6kha]] - bIns A chain + B chain – NMR<br /> |
| + | *Insulin complexes | ||
| - | + | **[[4xc4]] - hIns A chain + B chain + sulfatide + Zn<br /> | |
| - | + | ||
| - | **[[ | + | |
**[[1ben]] - hIns A chain + B chain + hydroxybenzamide + Zn<br /> | **[[1ben]] - hIns A chain + B chain + hydroxybenzamide + Zn<br /> | ||
**[[1tyl]], [[1tym]] - hIns A chain + B chain + hydroxyacetanilide + Zn<br /> | **[[1tyl]], [[1tym]] - hIns A chain + B chain + hydroxyacetanilide + Zn<br /> | ||
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**[[4cxn]], [[4cy7]], [[2wru]], [[2wrx]], [[2ws0]] - hIns A chain + B chain (mutant) + Ala derivative<br /> | **[[4cxn]], [[4cy7]], [[2wru]], [[2wrx]], [[2ws0]] - hIns A chain + B chain (mutant) + Ala derivative<br /> | ||
**[[2wrv]] - hIns A chain + B chain (mutant) + His derivative<br /> | **[[2wrv]] - hIns A chain + B chain (mutant) + His derivative<br /> | ||
| - | **[[5jyq]] - Ins A chain + B chain + Pro derivative – Conus geographus<br /> | ||
**[[2oly]], [[2om0]], [[2omh]], [[2omi]] - hIns A chain + B chain + urea + resorcinol + Zn<br /> | **[[2oly]], [[2om0]], [[2omh]], [[2omi]] - hIns A chain + B chain + urea + resorcinol + Zn<br /> | ||
**[[2omg]] - hIns A chain + B chain + urea + cresol + Zn<br /> | **[[2omg]] - hIns A chain + B chain + urea + cresol + Zn<br /> | ||
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**[[6ck2]] - hIns A chain + B chain (mutant) + phenol + ornithine + Zn<br /> | **[[6ck2]] - hIns A chain + B chain (mutant) + phenol + ornithine + Zn<br /> | ||
**[[1qiz]] - hIns A chain (mutant) + B chain (mutant) + resorcinol + Zn<br /> | **[[1qiz]] - hIns A chain (mutant) + B chain (mutant) + resorcinol + Zn<br /> | ||
| - | **[[1ev3]], [[1ev6]], [[1uz9]], [[4gbn]], [[4gbc]], [[4gbi]], [[4gbk]], [[4gbl]] - hIns A chain + B chain + cresol + Zn<br /> | + | **[[1ev3]], [[1ev6]], [[1uz9]], [[4gbn]], [[4gbc]], [[4gbi]], [[4gbk]], [[4gbl]], [[6gnq]] - hIns A chain + B chain + cresol + Zn<br /> |
**[[1zeh]] - hIns A chain (mutant) + B chain (mutant) + cresol + Zn<br /> | **[[1zeh]] - hIns A chain (mutant) + B chain (mutant) + cresol + Zn<br /> | ||
**[[1evr]], [[4ajx]], [[3zu1]] - hIns A chain + B chain + resorcinol + Zn<br /> | **[[1evr]], [[4ajx]], [[3zu1]] - hIns A chain + B chain + resorcinol + Zn<br /> | ||
| - | **[[3q6e]] - hIns A chain + B chain + synthetic receptor<br /> | ||
| - | **[[2g54]], [[2g56]] - hIns B chain + insulin-degrading enzyme + Zn<br /> | ||
| - | **[[6b3q]] - hIns A chain + B chain + insulin-degrading enzyme (mutant)<br /> | ||
| - | **[[2wby]], [[2wc0]] - hIns A chain + B chain + insulin-degrading enzyme (mutant) + Zn<br /> | ||
| - | **[[3w11]], [[3w14]] - hIns A chain + B chain + insulin-degrading enzyme + antibody<br /> | ||
| - | **[[5wob]] - hIns A chain + B chain + insulin-degrading enzyme + antibody + Zn<br /> | ||
| - | **[[4oga]] - hIns A chain + B chain + insulin receptor + antibody<br /> | ||
| - | **[[6ce7]], [[6ce9]], [[6ceb]] - hIns A chain + B chain + insulin receptor – Cryo EM<br /> | ||
**[[5mam]] - hIns A chain + B chain + serotonin + Zn<br /> | **[[5mam]] - hIns A chain + B chain + serotonin + Zn<br /> | ||
**[[5mt9]], [[5mt3]] - hIns A chain + B chain + serotonin + arginine + Zn<br /> | **[[5mt9]], [[5mt3]] - hIns A chain + B chain + serotonin + arginine + Zn<br /> | ||
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**[[3mth]] - pIns A chain + B chain + methylparaben + Zn<br /> | **[[3mth]] - pIns A chain + B chain + methylparaben + Zn<br /> | ||
**[[7ins]] - pIns A chain + B chain + clupeine + cresol + Zn<br /> | **[[7ins]] - pIns A chain + B chain + clupeine + cresol + Zn<br /> | ||
| + | **[[5jyq]] - CgIns A chain + B chain + Pro derivative – ''Conus geographus''<br /> | ||
| + | |||
| + | *Insulin complexes with protein | ||
| + | |||
| + | **[[3q6e]] - hIns A chain + B chain + synthetic receptor<br /> | ||
| + | **[[7bw7]], [[7bw8]], [[7bwa]], [[7pg0]], [[7pg2]], [[7pg3]], [[7pg4]], [[7qid]], [[7sth]], [[7sti]], [[7stj]], [[7stk, [[8guy]] - hIns A chain + B chain + insulin receptor – Cryo EM<br /> | ||
| + | **[[7l7j]], [[7sl1]], [[7sl2]], [[7sl3]] - hIns A chain (mutant) + B chain + insulin receptor – Cryo EM<br /> | ||
| + | **[[7sl4]], [[7sl6]] - hIns A chain + B chain (mutant) + insulin receptor – Cryo EM<br /> | ||
| + | **[[7mqs]] - hIns A chain (mutant) + B chain (mutant) + insulin receptor – Cryo EM<br /> | ||
| + | **[[7yq3]], [[7yq4]], [[7yq5]], [[7yq6]] - hIns A chain + B chain + insulin receptor + DNA – Cryo EM<br /> | ||
| + | **[[2g54]], [[2g56]] - hIns B chain + insulin-degrading enzyme + Zn<br /> | ||
| + | **[[6b3q]] - hIns A chain + B chain + insulin-degrading enzyme<br /> | ||
| + | **[[6b3q]], [[6bfc]] - hIns A chain + B chain + insulin-degrading enzyme – Cryo EM<br /> | ||
| + | **[[2wby]], [[2wc0]] - hIns A chain + B chain + insulin-degrading enzyme (mutant) + Zn<br /> | ||
| + | **[[3w11]], [[5kqv]] - hIns A chain + B chain + insulin-degrading enzyme + antibody<br /> | ||
| + | **[[6b70]] - hIns A chain + B chain + insulin-degrading enzyme + antibody – Cryo EM<br /> | ||
| + | **[[6jk8]], [[7v3p]] - hIns A chain + B chain + IGF-1R – Cryo EM<br /> | ||
| + | **[[5wob]] - hIns A chain + B chain + insulin-degrading enzyme + antibody + Zn<br /> | ||
| + | **[[4oga]], [[6vep]] - hIns A chain + B chain + insulin receptor + antibody<br /> | ||
| + | **[[6ce7]], [[6ce9]], [[6ceb]], [[6hn5]] - hIns A chain + B chain + insulin receptor – Cryo EM<br /> | ||
| + | **[[6z7w]], [[6z7y]], [[6z7z]] - pIns A chain + B chain + antibody<br /> | ||
| + | **[[6z7z]] - pIns A chain + B chain + antibody<br /> | ||
| + | **[[7ins]] - pIns A chain + B chain + clupeine<br /> | ||
| + | **[[8ez0]] - mIns + insulin receptor – Cryo EM<br /> | ||
| + | **[[6veq]] - CgIns A chain + B chain + insulin receptor + antibody<br /> | ||
* Proinsulin | * Proinsulin | ||
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*Insulin lispro | *Insulin lispro | ||
| - | **[[5udp]] – | + | **[[5udp]] – LishIns – synthetic<br /> |
| + | **[[6nwv]] - hIns A chain + hInsLis B chain + cresol + Zn<br /> | ||
*Insulin glargine | *Insulin glargine | ||
**[[4iyd]], [[4iyf]], [[5viz]] – hIns – synthetic<br /> | **[[4iyd]], [[4iyf]], [[5viz]] – hIns – synthetic<br /> | ||
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}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
(Updated on 30-May-2023)
