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7ylf
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the chicken Toll-like receptor 15 TIR domain (2-mercaptoethanol adduct)== | |
| + | <StructureSection load='7ylf' size='340' side='right'caption='[[7ylf]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7ylf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7YLF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7YLF FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ylf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ylf OCA], [https://pdbe.org/7ylf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ylf RCSB], [https://www.ebi.ac.uk/pdbsum/7ylf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ylf ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/E5L3Q3_CHICK E5L3Q3_CHICK] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Toll-like receptors (TLRs) activate innate immunity in response to pathogen-associated molecular patterns (PAMPs). The ectodomain of a TLR directly senses a PAMP and the intracellular TIR domain dimerizes to initiate a signaling cascade. The TIR domains of TLR6 and TLR10, which belong to the TLR1 subfamily, have been structurally characterized in a dimer, whereas those of other subfamilies, including TLR15, have not been explored at the structural or molecular level. TLR15 is a TLR unique to birds and reptiles that responds to virulence-associated fungal and bacterial proteases. To reveal how the TLR15 TIR domain (TLR15(TIR)) triggers signaling, the crystal structure of TLR15(TIR) was determined in a dimeric form and a mutational study was performed. TLR15(TIR) forms a one-domain structure in which a five-stranded beta-sheet is decorated by alpha-helices, as shown for TLR1 subfamily members. TLR15(TIR) exhibits substantial structural differences from other TLRs at the BB and DD loops and alphaC2 helix that are involved in dimerization. As a result, TLR15(TIR) is likely to form a dimeric structure that is unique in its intersubunit orientation and the contribution of each dimerizing region. Further comparative analysis of TIR structures and sequences provides insights into the recruitment of a signaling adaptor protein by TLR15(TIR). | ||
| - | + | Structural analysis of the Toll-like receptor 15 TIR domain.,Ko KY, Song WS, Park J, Lee GS, Yoon SI IUCrJ. 2023 May 1;10(Pt 3):352-362. doi: 10.1107/S2052252523002956. PMID:37079400<ref>PMID:37079400</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 7ylf" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gallus gallus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ko KY]] | ||
| + | [[Category: Song WS]] | ||
| + | [[Category: Yoon SI]] | ||
Revision as of 05:35, 31 May 2023
Crystal structure of the chicken Toll-like receptor 15 TIR domain (2-mercaptoethanol adduct)
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