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8h9e

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'''Unreleased structure'''
 
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The entry 8h9e is ON HOLD until Paper Publication
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==Human ATP synthase F1 domain, state 1==
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<StructureSection load='8h9e' size='340' side='right'caption='[[8h9e]], [[Resolution|resolution]] 2.53&Aring;' scene=''>
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Authors: Lai, Y., Zhang, Y., Liu, F., Gao, Y., Gong, H., Rao, Z.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8h9e]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8H9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8H9E FirstGlance]. <br>
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Description: Human ATP synthase F1 domain, state 1
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8h9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8h9e OCA], [https://pdbe.org/8h9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8h9e RCSB], [https://www.ebi.ac.uk/pdbsum/8h9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8h9e ProSAT]</span></td></tr>
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[[Category: Gong, H]]
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</table>
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[[Category: Gao, Y]]
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== Function ==
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[[Category: Zhang, Y]]
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[https://www.uniprot.org/uniprot/ATIF1_HUMAN ATIF1_HUMAN] Endogenous F(1)F(o)-ATPase inhibitor limiting ATP depletion when the mitochondrial membrane potential falls below a threshold and the F(1)F(o)-ATP synthase starts hydrolyzing ATP to pump protons out of the mitochondrial matrix. Required to avoid the consumption of cellular ATP when the F(1)F(o)-ATP synthase enzyme acts as an ATP hydrolase. Indirectly acts as a regulator of heme synthesis in erythroid tissues: regulates heme synthesis by modulating the mitochondrial pH and redox potential, allowing FECH to efficiently catalyze the incorporation of iron into protoporphyrin IX to produce heme.<ref>PMID:12110673</ref> <ref>PMID:15528193</ref> <ref>PMID:19559621</ref> <ref>PMID:23135403</ref>
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[[Category: Liu, F]]
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== References ==
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[[Category: Rao, Z]]
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<references/>
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[[Category: Lai, Y]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Gao Y]]
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[[Category: Gong H]]
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[[Category: Lai Y]]
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[[Category: Liu F]]
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[[Category: Rao Z]]
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[[Category: Zhang Y]]

Revision as of 05:44, 31 May 2023

Human ATP synthase F1 domain, state 1

PDB ID 8h9e

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