This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Immunodeficiency virus protease 3D structures
From Proteopedia
(Difference between revisions)
| (7 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
==Immunodeficiency virus protease 3D structures == | ==Immunodeficiency virus protease 3D structures == | ||
| - | |||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | |||
| - | * | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| Line 10: | Line 5: | ||
*HIV-I protease | *HIV-I protease | ||
| - | **[[ | + | **[[1hhp]], [[1odw]], [[2hvp]], [[2pc0]], [[3hvp]], [[3ixo]], [[3phv]] – HIVP – HIV-I virus <br /> |
| - | **[[ | + | **[[1lv1]], [[1odx]], [[1g6l]], [[2g69]], [[2hb2]], [[3u71]], [[4yob]], [[4npu]] – HIVP (mutant) <br /> |
| - | **[[ | + | **[[1q9p]] – HIVP (mutant) - NMR<br /> |
| - | **[[ | + | **[[1ajv]], [[1g35]], [[7upj]] – HIVP + sulfonamide inhibitor <br /> |
| + | **[[1d4s]], [[1d4y]], [[1hpo]], [[2q3k]], [[3th9]], [[4mc1]], [[4mc2]], [[4mc6]], [[4mc9]], [[5bry]], [[5bs4]], [[5ult]], [[5uov]], [[5upz]] – HIVP (mutant) + sulfonamide inhibitor <br /> | ||
| + | **[[3qbf]], [[3qct]], [[3qpj]], [[3qrm]], [[3qro]], [[3qrs]], [[4gb2]] – HIVP (mutant) + pyrrolidine inhibitor <br /> | ||
**[[1hte]], [[1htf]], [[1htg]] – HIVP + penicillin inhibitor <br /> | **[[1hte]], [[1htf]], [[1htg]] – HIVP + penicillin inhibitor <br /> | ||
| - | **[[ | + | **[[2aqu]], [[3el1]], [[3tkg]], [[3tkw]], [[3tl9]], [[4jec]], [[4ll3]], [[5b18]], [[5kqx]], [[5kqy]], [[5kqz]], [[5kr0]], [[5kr1]], [[5kr2]] – HIVP + drug<br /> |
| - | **[[ | + | **[[1fb7]], [[1sdt]], [[1sdu]], [[1sdv]], [[2b7z]], [[2fgu]], [[2fgv]], [[2fxd]], [[2fxe]], [[2hs1]], [[2hs2]], [[2nmy]], [[2nmz]], [[2nnk]], [[2nnp]], [[2o4l]], [[2o4s]], [[2q5k]], [[2r5p]], [[2r5q]], [[2z54]], [[3bvb]], [[3cyw]], [[3cyx]], [[3d1x]], [[3d1z]], [[3d20]], [[3el4]], [[3el5]], [[3el9]], [[3k4v]], [[3lzs]], [[3oxx]], [[3oy4]], [[3s43]], [[3s45]], [[3s53]], [[3s54]], [[3s56]], [[3so9]], [[3spk]], [[3swj]], [[4npt]], [[4q5m]], [[4qgi]], [[4yoa]], [[5e5j]], [[5e5k]], [[5t8h]], [[6dif]], [[6dil]], [[6dj1]], [[6dj2]], [[6p9a]], [[6p9b]], [[6pu8]], [[7dt9]], [[8esx]], [[8esy]] – HIVP (mutant) + drug<br /> |
| - | **[[ | + | **[[1a8g]], [[1aid]], [[1c6x]], [[1c6y]], [[1c6z]], [[1c70]], [[1d4h]], [[1d4i]], [[1d4j]], [[1dif]], [[1ebw]], [[1eby]], [[1ebz]], [[1ec0]], [[1ec1]], [[1ec2]], [[1ec3]], [[1gno]], [[1hih]], [[1hiv]], [[1hos]], [[1hps]], [[1hpv]], [1hpx]], [[1hvc]], [[1hvh]], [[1hvi]], [[1hvj]], [[1hvk]], [[1hvl]], [[1hxb]], [[1hxw]], [[1kzk]], [[1msm]], [[1npw]], [[1ody]], [[1pro]], [[1sbg]], [[1sh9]], [[1upj]], [[1vij]], [[1vik]], [[1w5v]], [[1t3r]], [[1yt9]], [[1zp8]], [[1zpa]], [[1ztz]], [[2a4f]], [[2bpw]], [[2bpx]], [[2bpy]], [[2bpz]], [[2bqv]], [[2fde]], [[2pwc]], [[2pwr]], [[2qnn]], [[2upj]], [[2uxz]], [[2uy0]], [[2wkz]], [[2zga]], [[3aid]], [[3dcr]], [[3gga]], [[3ggv]], [[3ggx]], [[3i8w]], [[3kf0]], [[3kfn]], [[3kfp]], [[3kfr]], [[3kfs]], [[3m9f]], [[3mxd]], [[3mxe]], [[3r4b]], [[3s85]], [[3t11]], [[3tlh]], [[3zps]], [[3zpt]], [[3zpu]], [[4a6b]], [[4a6c]], [[4dfg]], [[4dqb]], [[4fe6]], [[4i8z]], [[4i8w]], [[4k4p]], [[4phv]], [[4u7q]], [[4u7v]], [[4u8w]] [[5ivq]], [[5ivr]], [[5ivs]], [[5ivt]], [[5w5w]], [[5yoj]], [[5yok]], [[6b36]], [[6b38]], [[6b3c]], [[6b3f]], [[6b3g]], [[6b3h]], [[9hvp]] – HIVP + inhibitor <br /> |
| - | **[[ | + | **[[1a8k]], [[1aaq]], [[1axa]], [[1bdl]], [[1bdr]], [[1bdq]], [[1bwa]], [[1bwb]], [[1gnm]], [[1gnn]], [[1hef]], [[1heg]], [[1mrx]], [[1mrw]], [[1msn]], [[1sgu]], [[1t7i]], [[1tcx]], [[1w5w]], [[1w5x]], [[1w5y]], [[1zbg]], [[2aid]], [[2a1e]], [[2aoc]], [[2aod]], [[2aoe]], [[2azc]], [[2f3k]], [[2f80]], [[2f81]], [[2f8g]], [[2fdd]], [[2hb3]], [[2hc0]], [[2i0a]], [[2i0d]], [[2idw]], [[2ien]], [[2ieo]], [[2j9j]], [[2j9k]], [[2je4]], [[2pk5]], [[2pk6]], [[2q54]], [[2qci]], [[2qd6]], [[2qd7]], [[2qd8]], [[2qhy]], [[2qhz]], [[2qi1]], [[2qi7]], [[2r38]], [[2r3t]], [[2r43]], [[2psu]], [[2psv]], [[2wl0]], [[2xye]], [[2xyf]], [[2z4o]], [[3bva]], [[3bxr]], [[3bxs]], [[3d1y]], [[3dk1]], [[3djk]], [[3fx5]], [[3h5b]], [[3i6o]], [[3i7e]], [[3kdb]], [[3kdc]], [[3kdd]], [[3ok9]], [[3qaa]], [[3qbf]], [[3qih]], [[3qn8]], [[3qp0]], [[3qpj]], [[3qrm]], [[3qro]], [[3qrs]], [[3sa3]], [[3sa4]], [[3sa5]], [[3sa6]], [[3sa7]], [[3sa8]], [[3sa9]], [[3saa]], [[3sab]], [[3sac]], [[3st5]], [[3tof]], [[3tog]], [[3toh]], [[3vf5]], [[3vf7]], [[3vfa]], [[3vfb]], [[4a4q]], [[4cpq]], [[4cpr]], [[4cps]], [[4cpt]], [[4cpu]], [[4cpw]], [[4cpx]], [[4coe]], [[4cp7]], [[4djo]], [[4djp]], [[4djq]], [[4djr]], [[4dqc]], [[4dqe]], [[4dqf]], [[4dqg]], [[4dqh]], [[4hdb]], [[4hdf]], [[4hdp]], [[4he9]], [[4heg]], [[4kb9]], [[4m8x]], [[4m8y]], [[4zip]], [[4zis]], [[5agz]], [[5ah6]], [[5ah8]], [[5ah9]], [[5aha]], [[5ahb]], [[5ahc]], [[5ah7]], [[5cok]], [[5con]], [[5coo]], [[5cop]], [[5dgu]], [[5dgw]], [[5jfp]], [[5jfu]], [[5jg1]], [[5kao]], [[5jfp]], [[5jfu]], [[5jg1]], [[5kao]], [[5vea]], [[5vck]], [[5vj3]], [[6dj5]], [[6dj7]], [[6ptp]] – HIVP (mutant) + inhibitor <br /> |
| + | **[[1ajx]], [[1dmp]], [[1hvr]], [[1hwr]], [[1qbr]], [[1qbs]], [[1qbt]], [[1qbu]] – HIVP + urea inhibitor <br /> | ||
| + | **[[1bv9]], [[1mer]], [[1mes]], [[1met]], [[1meu]] – HIVP (mutant) + urea inhibitor <br /> | ||
| + | **[[1bve]], [[1bvg]] – HIVP (mutant) + urea inhibitor - NMR<br /> | ||
**[[2zye]] – HIVP (mutant) + inhibitor - neutron<br /> | **[[2zye]] – HIVP (mutant) + inhibitor - neutron<br /> | ||
| Line 25: | Line 25: | ||
**[[4tvg]], [[5hvp]] – HIVP + pepstatin peptide<br /> | **[[4tvg]], [[5hvp]] – HIVP + pepstatin peptide<br /> | ||
**[[4f73]], [[4f74]], [[4f75]], [[4f76]], [[4ep2]], [[4ep3]], [[4epj]], [[4eq0]], [[4eqj]] – HIVP + substrate peptide<br /> | **[[4f73]], [[4f74]], [[4f75]], [[4f76]], [[4ep2]], [[4ep3]], [[4epj]], [[4eq0]], [[4eqj]] – HIVP + substrate peptide<br /> | ||
| - | **[[ | + | **[[1f7a]], [[1kj4]], [[1kj7]], [[1kjf]], [[1kjg]], [[1kjh]], [[1tsq]], [[1tsu]], [[2aof]], [[2aog]], [[2aoh]], [[2fns]], [[2fnt]], [[3d3t]], [[3dox]], [[5yrs]], [[4fae]], [[4faf]], [[6bra]] – HIVP (mutant) + substrate peptide<br /> |
| - | **[[ | + | **[[2nxd]], [[2nxl]], [[2nxm]], [[3b7v]], [[3b80]], [[4e43]], [[4fl8]], [[4flg]], [[4fm6]], [[4gzf]], [[4qj2]], [[4qj6]], [[4qj7]], [[4qj8]], [[4qj9]], [[4qja]] – HIVP (mutant) + peptide<br /> |
| - | **[[ | + | **[[1cpi]] – HIVP + peptide inhibitor<br /> |
| - | **[[1lzq]], [[1z8c]], [[1zbg]], [[1zj7]], [[1zpk]] – HIVP (mutant) + peptidomimetic inhibitor<br /> | + | **[[1a30]], [[1a9m]] – HIVP (mutant) + peptide inhibitor<br /> |
| + | **[[1hbv]], [[1mtr]], [[1zsr]] – HIVP + peptidomimetic inhibitor<br /> | ||
| + | **[[1d4k]], [[1d4l]], [[1lzq]], [[1z8c]], [[1zbg]], [[1zj7]], [[1zpk]] – HIVP (mutant) + peptidomimetic inhibitor<br /> | ||
**[[4i3s]], [[4i3r]] – HIVP Gp120 + antibody<br /> | **[[4i3s]], [[4i3r]] – HIVP Gp120 + antibody<br /> | ||
| + | **[[6nc3]] – HIVP Gp120 (mutant) + Gp41 (mutant) + antibody – Cryo EM<br /> | ||
*Drug resistant HIV-I protease | *Drug resistant HIV-I protease | ||
| - | **[[ | + | **[[1daz]], [[1dw6]], [[1ebk]], [[1rpi]], [[1rq9]], [[1tw7]], [[3uf3]], [[2avm]], [[2avo]], [[2avq]], [[2avs]], [[2avv]], [[3mws]], [[3oq7]], [[3oqa]], [[3oqd]], [[3pj6]], [[4nkk]], [[4q1w]], [[4q1x]], [[4q1y]], [[4qlh]], [[4z4x]], [[4z50]], [[5t2e]], – HIVP (mutant) <br /> |
| - | **[[ | + | **[[1bv7]], [[1hvs]], [[1n49]], [[2p3a]], [[2p3b]], [[2p3c]], [[2p3d]], [[3r0w]], [[3r0y]], [[3t3c]], [[4j54]], [[4j55]], [[4njs]], [[4rvi]], [[4rvx]], [[4ye3]], [[4yhq]] – HIVP (mutant) + inhibitor <br /> |
**[[4rvj]] – HIVP + drug<br /> | **[[4rvj]] – HIVP + drug<br /> | ||
| - | **[[ | + | **[[1rv7]], [[1t7j]], [[3ekp]], [[3ekq]], [[3ekt]], [[3ekv]], [[3ekw]], [[3eky]], [[3el0]], [[3el5]], [[3el9]], [[3em3]], [[3em4]], [[3em6]], [[3ggu]], [[3lzu]], [[3ttp]], [[3ucb]], [[3ufn]], [[3u7s]], [[3uhl]], [[4eyr]], [[4j5j]], [[4l1t]], [[4njt]], [[4nju]], [[4njv]], [[5t2z]] – HIVP (mutant) + drug<br /> |
| - | **[[4obd]], [[4obf]], [[4obg]], [[4obh]], [[4obj]], [[4obk]] – HIVP (mutant) + peptide<br /> | + | **[[3ots]], [[3oty]], [[3ou1]], [[3ou3]], [[3ou4]], [[3oua]], [[3oub]], [[3ouc]], [[3oud]] – HIVP + peptide<br /> |
| - | **[[1fej]], [[1ff0]], [[1fff]], [[1ffi]], [[1fg6]], [[1fg8]], [[1fgc]] – HIVP (mutant) + substrate analog<br /> | + | **[[4obd]], [[4obf]], [[4obg]], [[4obh]], [[4obj]], [[4obk]], [[4gye]] – HIVP (mutant) + peptide<br /> |
| + | **[[1fej]], [[1ff0]], [[1fff]], [[1ffi]], [[1fg6]], [[1fg8]], [[1fgc]], [[6o48]], [[6o54]], [[6o57]], [[6o5a]], [[6o5x]] – HIVP (mutant) + substrate analog<br /> | ||
*HIV-I protease complex at the top of the flap | *HIV-I protease complex at the top of the flap | ||
| Line 57: | Line 61: | ||
**[[3ebz]] – HIVP + drug<br /> | **[[3ebz]] – HIVP + drug<br /> | ||
| - | **[[ | + | **[[1ida]], [[1idb]], [[1ivq]], [[1jld]], [[1hsg]], [[1hsh]], [[1hsi]], [[2mip]], [[3ec0]], [[3ecg]], – HIVP + inhibitor<br /> |
| - | **[[ | + | **[[1ivp]], [[3upj]], [[4upj]], [[5upj]], [[6upj]] – HIVP (mutant) + inhibitor <br /> |
| + | **[[2hpf]], [[2hpe]] – HIVP + peptide<br /> | ||
**[[5cay]] – HIVP + CD4<br /> | **[[5cay]] – HIVP + CD4<br /> | ||
| - | *FIV | + | *FIV |
| - | **[[1b11]], [[ | + | **[[1b11]], [[1fiv]], [[2fiv]], [[3fiv]], [[3tlh]], [[4fiv]], [[5fiv]], [[6fiv]] – FIVP + inhibitor – cat immunodeficiency virus <br /> |
**[[2hah]] – FIVP (mutant) + inhibitor <br /> | **[[2hah]] – FIVP (mutant) + inhibitor <br /> | ||
**[[3ogp]], [[3ogq]] – FIVP (mutant) + drug<br /> | **[[3ogp]], [[3ogq]] – FIVP (mutant) + drug<br /> | ||
| - | *SIV | + | *SIV |
**[[1sip]] – SIVP – monkey immunodeficiency virus<br /> | **[[1sip]] – SIVP – monkey immunodeficiency virus<br /> | ||
| Line 74: | Line 79: | ||
**[[2bf1]] – SIVP Gp120 <br /> | **[[2bf1]] – SIVP Gp120 <br /> | ||
**[[1tcw]], [[2sam]], [[1siv]] – SIVP + inhibitor <br /> | **[[1tcw]], [[2sam]], [[1siv]] – SIVP + inhibitor <br /> | ||
| - | **[[1ytg]], [[1yth]], [[1yti]], [[1ytj]] – SIVP | + | **[[1ytg]], [[1yth]], [[1yti]], [[1ytj]] – SIVP |
}} | }} | ||
| Line 82: | Line 87: | ||
* [[Human Immunodeficiency Virus]] | * [[Human Immunodeficiency Virus]] | ||
* [http://cdn.rcsb.org/pdb101/learn/resources/structural-biology-of-hiv/index.html Structural Biology of HIV], an interactive Flash graphic of the virion with explanations of its components. | * [http://cdn.rcsb.org/pdb101/learn/resources/structural-biology-of-hiv/index.html Structural Biology of HIV], an interactive Flash graphic of the virion with explanations of its components. | ||
| - | |||
| - | |||
| - | |||
| - | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
Immunodeficiency virus protease 3D structures
Updated on 31-May-2023
Additional Resources
For additional information, see:
- Human Immunodeficiency Virus
- Structural Biology of HIV, an interactive Flash graphic of the virion with explanations of its components.
