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Interleukin 3D structures

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(New page: ==3D structures of interleukin== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *IL-1 α **2ila - hIL-1 α - ...)
Current revision (10:05, 4 June 2023) (edit) (undo)
 
(4 intermediate revisions not shown.)
Line 17: Line 17:
**[[3ltq]] - hIL-1 β residues 117-269 <BR />
**[[3ltq]] - hIL-1 β residues 117-269 <BR />
**[[3pok]] - hIL-1 β residues 117-269 (mutant) <BR />
**[[3pok]] - hIL-1 β residues 117-269 (mutant) <BR />
 +
**[[6y8i]], [[6y8m]] - hIL-1 β residues 117-269 + pyridine derivative<BR />
**[[1itb]] - hIL-1 β + IL-1 receptor 1 extracellular domain<BR />
**[[1itb]] - hIL-1 β + IL-1 receptor 1 extracellular domain<BR />
**[[3o4o]] - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein<BR />
**[[3o4o]] - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein<BR />
**[[4dep]] - hIL-1 β + IL-1 receptor 1 + IL-1 receptor accessory protein<BR />
**[[4dep]] - hIL-1 β + IL-1 receptor 1 + IL-1 receptor accessory protein<BR />
-
**[[4g6j]], [[4g6m]], [[5bvp]] - hIL-1 β + antibody<br />
+
**[[4g6j]], [[4g6m]], [[5bvp]], [[7chy]], [[7chz]], 7z4t]] - hIL-1 β + antibody<br />
**[[2kh2]] - hIL-1 β + SCFV - NMR<BR />
**[[2kh2]] - hIL-1 β + SCFV - NMR<BR />
**[[1md6]] – mIL-1F5 – mouse<BR />
**[[1md6]] – mIL-1F5 – mouse<BR />
Line 30: Line 31:
**[[1m47]], [[1m4c]], [[3ink]] – hIL-2<BR />
**[[1m47]], [[1m4c]], [[3ink]] – hIL-2<BR />
-
**[[3qb1]] - hIL-2 (mutant)<br />
+
**[[3qb1]], [[7m2g]], [[7ra9]], [[7raa]] - hIL-2 (mutant)<br />
**[[1irl]] – hIL-2 (mutant) - NMR<BR />
**[[1irl]] – hIL-2 (mutant) - NMR<BR />
**[[5m5e]] - hIL-2 + IL-2 receptor β + cytokine receptor common γ<BR />
**[[5m5e]] - hIL-2 + IL-2 receptor β + cytokine receptor common γ<BR />
Line 39: Line 40:
**[[1pw6]], [[1py2]], [[1m48]], [[1m49]] – hIL-2 + inhibitor<BR />
**[[1pw6]], [[1py2]], [[1m48]], [[1m49]] – hIL-2 + inhibitor<BR />
**[[4nej]], [[4nem]] – hIL-2 + methylfuran carboxylate derivative<BR />
**[[4nej]], [[4nem]] – hIL-2 + methylfuran carboxylate derivative<BR />
-
**[[5lqb]] - hIL-2 + antibody<br />
+
**[[5lqb]], [[6ye3]], [[7dr4]] - hIL-2 + antibody<br />
 +
**[[7zmz]] - hIL-2 + CD25<br />
**[[4yue]] - mIL-2 + antibody<br />
**[[4yue]] - mIL-2 + antibody<br />
**[[4yqx]] - IL-2 + antibody - rat<br />
**[[4yqx]] - IL-2 + antibody - rat<br />
**[[4zf7]] – hIL-2 - ferret<BR />
**[[4zf7]] – hIL-2 - ferret<BR />
 +
**[[7cjn]], [[7d9m]] – IL-2 – grass carp<BR />
*IL-3
*IL-3
**[[1jli]] – hIL-3 (mutant) – NMR<BR />
**[[1jli]] – hIL-3 (mutant) – NMR<BR />
 +
**[[6nmy]] – hIL-3 + IL-3 receptor α + cytokine receptor common subunit β<BR />
**[[5uv8]], [[5uwc]] – hIL-3 (mutant) + IL-3 receptor α<BR />
**[[5uv8]], [[5uwc]] – hIL-3 (mutant) + IL-3 receptor α<BR />
**[[2l3o]] – mIL-3 residues 33-156 (mutant) - NMR
**[[2l3o]] – mIL-3 residues 33-156 (mutant) - NMR
Line 72: Line 76:
*IL-6
*IL-6
-
**[[1alu]] – hIL-6<BR />
+
**[[1alu]], [[7nxz]] – hIL-6<BR />
**[[1il6]], [[2il6]] – hIL-6 - NMR<BR />
**[[1il6]], [[2il6]] – hIL-6 - NMR<BR />
**[[1p9m]] - hIL-6 + IL-6 receptor α and β<br />
**[[1p9m]] - hIL-6 + IL-6 receptor α and β<br />
 +
**[[8d82]] - hIL-6 + IL-6 receptor α and β – Cryo EM<br />
**[[5fuc]] - hIL-6 + IL-6 receptor α + VHH6<br />
**[[5fuc]] - hIL-6 + IL-6 receptor α + VHH6<br />
**[[4j4l]] – hIL-6 + internalin B<BR />
**[[4j4l]] – hIL-6 + internalin B<BR />
Line 88: Line 93:
*IL-8
*IL-8
-
**[[3il8]], [[5d14]], [[4xdx]] – hIL-8 residues 28-99<BR />
+
**[[6n2u]] – hIL-8 <BR />
**[[1il8]], [[2il8]], [[5wdz]] – hIL-8 - NMR<BR />
**[[1il8]], [[2il8]], [[5wdz]] – hIL-8 - NMR<BR />
**[[1qe6]], [[1icw]] – hIL-8 (mutant) <BR />
**[[1qe6]], [[1icw]] – hIL-8 (mutant) <BR />
**[[1ikl]], [[1ikm]] - hIL-8 (mutant) - NMR<BR />
**[[1ikl]], [[1ikm]] - hIL-8 (mutant) - NMR<BR />
 +
**[[3il8]], [[5d14]], [[4xdx]] – hIL-8 residues 28-99<BR />
 +
**[[6xmn]] – hIL-8 residues 28-93 + CXCR1 N-terminal - NMR<BR />
**[[1rod]] - hIL-8/melanoma growth stimulating protein – NMR<br />
**[[1rod]] - hIL-8/melanoma growth stimulating protein – NMR<br />
-
**[[1ilp]], [[1ilq]] - hIL-8 + IL-8 receptor peptide
+
**[[1ilp]], [[1ilq]] - hIL-8 + IL-8 receptor peptide<br />
 +
**[[6wzm]] – hIL-8 + antibody<BR />
 +
**[[6lfm]], [[6lfo]]– hIL-8 in G-protein coupled receptor – Cryo EM<br />
 +
 
 +
*IL-9
 +
 
 +
**[[7ox6]] – hIL-9 - NMR<BR />
 +
**[[7ox5]] - hIL-9 + IL—9 receptor a<br />
 +
**[[7ox1]], [[7ox2]], [[7ox3]] - hIL-9 + antibody<br />
 +
**[[7xcb]] – mIL-9 <BR />
 +
**[[7ox4]] – mIL-9 + antibody<BR />
*IL-10
*IL-10
Line 119: Line 136:
**[[1f42]] - hIL-12 β P40 domain<BR />
**[[1f42]] - hIL-12 β P40 domain<BR />
**[[3hmx]] - hIL-12 α and β+ antibody<br />
**[[3hmx]] - hIL-12 α and β+ antibody<br />
-
**[[4oe8]], [[4og9]], [[5njd]] - hIL-12 β + hIL-23 α + antibody<br />
+
**[[5mj3]], [[5mj4]], [[5njd]] - hIL-12 β + hIL-23 α + antibody<br />
**[[5mzv]] - hIL-12 β + hIL-23 α + hIL-23 receptor + antibody<br />
**[[5mzv]] - hIL-12 β + hIL-23 α + hIL-23 receptor + antibody<br />
 +
**[[6wdq]] - hIL-12 β + hIL-23 α + hIL-12 receptor + hIL-23 receptor <br />
**[[5mxa]] - hIL-12 β + hIL- 23 α<br />
**[[5mxa]] - hIL-12 β + hIL- 23 α<br />
**[[5mj3]], [[5mj4]] - hIL-12 β + hIL-23 α + alphabody MB3<br />
**[[5mj3]], [[5mj4]] - hIL-12 β + hIL-23 α + alphabody MB3<br />
-
**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin
+
**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin<br />
 +
**[[6uib]] - hIL-12 β + hIL- 23 α + peptide<br />
 +
**[[6sff]], [[6smc]], [[6sp3]], [[7pur]], [[7r3n]] - mIL-12 β <br />
*IL-13
*IL-13
Line 132: Line 152:
**[[3lb6]] - hIL-13 + IL-13 receptor α2<BR />
**[[3lb6]] - hIL-13 + IL-13 receptor α2<BR />
**[[3bpo]], [[5e4e]] - hIL-13 residues 20-145 + IL-4 receptor α + IL-13 receptor α<br />
**[[3bpo]], [[5e4e]] - hIL-13 residues 20-145 + IL-4 receptor α + IL-13 receptor α<br />
-
**[[5l6y]] - hIL-13 + antibody<br />
+
**[[5l6y]], [[7rew]] - hIL-13 + antibody<br />
*IL-15
*IL-15
Line 149: Line 169:
**[[4hr9]] - hIL-17A (mutant)<br />
**[[4hr9]] - hIL-17A (mutant)<br />
**[[5n92]] - hIL-17A + hIL-17F <br />
**[[5n92]] - hIL-17A + hIL-17F <br />
 +
**[[7uwm]] - hIL-17A + IL-17A receptor α – Cryo EM<br />
**[[4hsa]] - hIL-17A (mutant) + IL-17A receptor α <br />
**[[4hsa]] - hIL-17A (mutant) + IL-17A receptor α <br />
**[[5nan]] - hIL-17A + hIL-17F + IL-17A receptor α <br />
**[[5nan]] - hIL-17A + hIL-17F + IL-17A receptor α <br />
-
**[[2vxs]], [[4qhu]] - hIL-17A + antibody<BR />
+
**[[7uwn]] - hIL-17A + IL-17A receptor α + IL-17A receptor gamma<br />
 +
**[[7zan]] - hIL-17A (mutant) + IL-17A receptor α + IL-17A receptor gamma<br />
 +
**[[2vxs]], [[4qhu]], [[6wio]], [[6wir]], [[7wkx]], [[7z2m]] - hIL-17A + antibody<BR />
 +
**[[8b7w]], [[8dy1]], [[8dy5]] - hIL-17A + scFv<BR />
 +
**[[8dyf]], [[8dyg]], [[8dyh]], [[8dyi]] - hIL-17A + inhibitor<BR />
**[[5vb9]] - hIL-17A + peptide inhibitor<BR />
**[[5vb9]] - hIL-17A + peptide inhibitor<BR />
 +
**[[7ama]], [[7amg]] - hIL-17A + modulator<br />
**[[5hi5]], [[5hi4]], [[5hi3]], [[5hhx]], [[5hhv]] - hIL-17A + peptide inhibitor + antibody<BR />
**[[5hi5]], [[5hi4]], [[5hi3]], [[5hhx]], [[5hhv]] - hIL-17A + peptide inhibitor + antibody<BR />
-
**[[1jpy]] – hIL-17F<BR />
+
**[[1jpy]], [[6hgo]] – hIL-17F<BR />
-
**[[3jvf]] - hIL-17F + IL-17 receptor α
+
**[[6ppg]] – hIL-17F + antibody<BR />
 +
**[[3jvf]], [[6hg4]], [[6hg9]] - hIL-17F + IL-17 receptor α
*IL-18 (Interferon-γ inducing factor)
*IL-18 (Interferon-γ inducing factor)
Line 188: Line 215:
**[[3dlq]], [[3dgc]] - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1<br />
**[[3dlq]], [[3dgc]] - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1<br />
**[[3q1s]] - hIL-22 residues 29-179 (mutant) + antibody<br />
**[[3q1s]] - hIL-22 residues 29-179 (mutant) + antibody<br />
 +
**[[6weo]] - hIL-22 + IL-22 receptor + IL-10 receptor <br />
**[[4o6k]] – IL-22 – zebra fish<BR />
**[[4o6k]] – IL-22 – zebra fish<BR />
Line 201: Line 229:
**[[6gg1]] - hIL-24<br />
**[[6gg1]] - hIL-24<br />
**[[6df3]] - hIL-24 + IL—22 receptor α1 + IL-20 receptor β<br />
**[[6df3]] - hIL-24 + IL—22 receptor α1 + IL-20 receptor β<br />
 +
 +
*IL-25
 +
 +
**[[7uwj]], [[7uwk]] - hIL-25 + IL—17 receptor b – Cryo EM<br />
 +
**[[7uwl]] - hIL-25 + IL—17 receptor a + IL—17 receptor b – Cryo EM<br />
 +
 +
*IL-27
 +
 +
**[[7u7n]], [[8d85]] - hIL-27 + IL—27 receptor a + IL-6 receptor b – Cryo EM<br />
 +
**[[7zxk]] - hIL-27 + antibody<br />
 +
**[[7zg0]] - mIL-27 + IL—27 receptor a <br />
 +
**[[7z0l]] - mIL-27 + IL—27 receptor a + IL-6 receptor b – Cryo EM<br />
*IL-28
*IL-28
Line 214: Line 254:
**[[2kll]] - hIL-33 residues 110-270 - NMR<BR />
**[[2kll]] - hIL-33 residues 110-270 - NMR<BR />
 +
**[[4kc3]] - hIL-33 + IL—1 receptor-like 1<br />
 +
**[[5iv4]] - mIL-33 + IL—1 receptor-like 1 + IL-1 receptor accessory protein<br />
*IL-34
*IL-34
Line 225: Line 267:
*IL-36
*IL-36
 +
**[[6hpi]] - hIL-36 α - NMR<br />
**[[4ize]] - hIL-36 γ<br />
**[[4ize]] - hIL-36 γ<br />
-
**[[6p9e]] - hIL-36 g + antagonist<br />
+
**[[6p9e]] - hIL-36 γ + antagonist<br />
*IL-37
*IL-37

Current revision

3D structures of interleukin

Updated on 04-June-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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