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1kzh

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[[Image:1kzh.jpg|left|200px]]
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{{Structure
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|PDB= 1kzh |SIZE=350|CAPTION= <scene name='initialview01'>1kzh</scene>, resolution 2.55&Aring;
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The line below this paragraph, containing "STRUCTURE_1kzh", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=X:2&#39;-DEOXY-N7-(8,9-DIHYDRO-9-HYDROXY-10-DEHYDROXY-AFLATOXIN)GUANOSINE+MONOPHOSPHATE'>X</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Diphosphate--fructose-6-phosphate_1-phosphotransferase Diphosphate--fructose-6-phosphate 1-phosphotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.90 2.7.1.90] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= BB0020 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=139 Borrelia burgdorferi])
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|DOMAIN=
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{{STRUCTURE_1kzh| PDB=1kzh | SCENE= }}
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|RELATEDENTRY=[[1pfk|1PFK]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kzh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kzh OCA], [http://www.ebi.ac.uk/pdbsum/1kzh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1kzh RCSB]</span>
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'''Structure of a pyrophosphate-dependent phosphofructokinase from the Lyme disease spirochete Borrelia burgdorferi'''
'''Structure of a pyrophosphate-dependent phosphofructokinase from the Lyme disease spirochete Borrelia burgdorferi'''
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[[Category: Roberson, R S.]]
[[Category: Roberson, R S.]]
[[Category: Ronimus, R S.]]
[[Category: Ronimus, R S.]]
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[[Category: borrelia burgdorferi]]
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[[Category: Borrelia burgdorferi]]
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[[Category: phosphofructokinase]]
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[[Category: Phosphofructokinase]]
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[[Category: phosphotransferase]]
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[[Category: Phosphotransferase]]
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[[Category: pyrophosphate]]
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[[Category: Pyrophosphate]]
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[[Category: spirochete]]
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[[Category: Spirochete]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:21:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:55:53 2008''
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Revision as of 20:21, 2 May 2008

Image:1kzh.jpg

Template:STRUCTURE 1kzh

Structure of a pyrophosphate-dependent phosphofructokinase from the Lyme disease spirochete Borrelia burgdorferi


Overview

The structure of the 60 kDa pyrophosphate (PP(i))-dependent phosphofructokinase (PFK) from Borrelia burgdorferi has been solved and refined (R(free) = 0.243) at 2.55 A resolution. The domain structure of eubacterial ATP-dependent PFKs is conserved in B. burgdorferi PFK, and there are three large insertions relative to E. coli PFK, including a helical domain containing a hairpin structure that interacts with the active site. Asp177, conserved in all PP(i) PFKs, negates the binding of the alpha-phosphate group of ATP and likely contacts the essential Mg(2+) cation via a water molecule. Asn181 blocks the binding of the adenine moiety of ATP. Lys203 hydrogen bonds to a sulfate anion that likely mimics PP(i) substrate binding.

About this Structure

1KZH is a Single protein structure of sequence from Borrelia burgdorferi. Full crystallographic information is available from OCA.

Reference

The structure of a pyrophosphate-dependent phosphofructokinase from the Lyme disease spirochete Borrelia burgdorferi., Moore SA, Ronimus RS, Roberson RS, Morgan HW, Structure. 2002 May;10(5):659-71. PMID:12015149 Page seeded by OCA on Fri May 2 23:21:51 2008

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