This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


8hvh

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8hvh is ON HOLD until Paper Publication
+
==Cryo-EM structure of ABC transporter ABCC3==
-
 
+
<StructureSection load='8hvh' size='340' side='right'caption='[[8hvh]], [[Resolution|resolution]] 3.07&Aring;' scene=''>
-
Authors:
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[8hvh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HVH FirstGlance]. <br>
-
Description:
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hvh OCA], [https://pdbe.org/8hvh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hvh RCSB], [https://www.ebi.ac.uk/pdbsum/8hvh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hvh ProSAT]</span></td></tr>
-
[[Category: Unreleased Structures]]
+
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MRP3_HUMAN MRP3_HUMAN] ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:11581266, PubMed:15083066, PubMed:10359813). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:15083066, PubMed:11581266). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:11581266, PubMed:10359813).[UniProtKB:O88563]<ref>PMID:10359813</ref> <ref>PMID:11581266</ref> <ref>PMID:15083066</ref> <ref>PMID:35307651</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Chen YX]]
 +
[[Category: Wang FF]]
 +
[[Category: Wang J]]
 +
[[Category: Zhou CZ]]

Revision as of 05:42, 7 June 2023

Cryo-EM structure of ABC transporter ABCC3

PDB ID 8hvh

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8hvh"
Personal tools