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5c2a

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==PDE10 complexed with 6-chloro-2-cyclopropyl-N-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-pyrimidin-4-amine==
==PDE10 complexed with 6-chloro-2-cyclopropyl-N-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-pyrimidin-4-amine==
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<StructureSection load='5c2a' size='340' side='right' caption='[[5c2a]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='5c2a' size='340' side='right'caption='[[5c2a]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5c2a]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C2A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C2A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5c2a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C2A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5C2A FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4Y2:6-CHLORO-2-CYCLOPROPYL-N-[(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHYL]-5-METHYLPYRIMIDIN-4-AMINE'>4Y2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4Y2:6-CHLORO-2-CYCLOPROPYL-N-[(2,4-DIMETHYL-1,3-THIAZOL-5-YL)METHYL]-5-METHYLPYRIMIDIN-4-AMINE'>4Y2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5c1w|5c1w]], [[5c28|5c28]], [[5c29|5c29]], [[5c2e|5c2e]], [[5c2h|5c2h]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5c2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c2a OCA], [https://pdbe.org/5c2a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5c2a RCSB], [https://www.ebi.ac.uk/pdbsum/5c2a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5c2a ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c2a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c2a OCA], [http://pdbe.org/5c2a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c2a RCSB], [http://www.ebi.ac.uk/pdbsum/5c2a PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5c2a" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5c2a" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Yan, Y]]
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[[Category: Homo sapiens]]
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[[Category: Complex]]
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[[Category: Large Structures]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Yan Y]]
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[[Category: Inhibitor]]
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[[Category: Phosphodiesterase]]
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Current revision

PDE10 complexed with 6-chloro-2-cyclopropyl-N-[(2,4-dimethylthiazol-5-yl)methyl]-5-methyl-pyrimidin-4-amine

PDB ID 5c2a

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