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Insulin-like growth factor receptor

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<StructureSection load='' size='450' side='right' scene='Journal:JBSD:38/Cv/1' caption='Human insulin-like growth factor 1 receptor (PDB code [[3i81]])'>
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<StructureSection load='3i81' size='350' side='right' scene='' caption='Human insulin-like growth factor 1 receptor complex with inhibitor (PDB code [[3i81]])'>
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'''Insulin-like growth factor receptors''' (IGFR) are transmembrane receptors which are stimulated by insulin-like growth factors (IGF). IGFR contains 2 extracellular α chains and 2 transmembranal β chains. Upon binding of IGF, a tyrosine in the β chain becomes autophosphorylated and triggers a cascade of intracellular signaling.
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'''Insulin-like growth factor receptors''' (IGFR) are transmembrane receptors which are stimulated by insulin-like growth factors (IGF). IGFR contains 2 extracellular α chains and 2 transmembranal β chains. Upon binding of IGF, a tyrosine in the β chain becomes autophosphorylated and triggers a cascade of intracellular signaling. The insulin-like growth factor 1 (IGF-1) receptor belongs to the large class of [[Receptor tyrosine kinases|tyrosine kinase receptors]]. See also [[IGF1]], [[Growth factors]] and [[Kinase-linked, enzyme-linked and related receptors]].
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=== Memory-Enhancement by Traditional Chinese Medicine? <ref>doi 10.1080/07391102.2012.741052</ref>===
=== Memory-Enhancement by Traditional Chinese Medicine? <ref>doi 10.1080/07391102.2012.741052</ref>===
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__NOTOC__
__NOTOC__
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===3D structures of insulin-like growth factor receptor===
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==3D structures of insulin-like growth factor receptor==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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==IGFR I==
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*IGFR I
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[[1igr]] – hIGFR I domains 1-3 – human<BR />
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**[[1igr]] – hIGFR I domains 1-3 31-492– human<BR />
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[[1jqh]], [[1p4o]] - hIGFR I kinase domain (mutant) <BR />
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**[[1jqh]], [[1p4o]] - hIGFR I kinase domain (mutant) 983-1286<BR />
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[[1m7n]] - hIGFR I kinase domain<BR />
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**[[1m7n]] - hIGFR I kinase domain<BR />
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[[1k3a]] - hIGFR I kinase domain + insulin receptor substrate peptide<BR />
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**[[1k3a]] - hIGFR I kinase domain + insulin receptor substrate peptide<BR />
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[[2oj9]], [[2zm3]], [[3d94]], [[3f5p]], [[3i81]], [[3lvp]], [[3nw5]], [[3nw6]], [[3nw7]], [[3lw0]], [[3qqu]], [[3o23]] - hIGFR I kinase domain + inhibitor<BR />
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**[[2oj9]], [[2zm3]], [[3d94]], [[3f5p]], [[3i81]], [[3lvp]], [[3nw5]], [[3nw6]], [[3nw7]], [[3lw0]], [[3qqu]], [[3o23]], [[4d2r]], [[5fxq]], [[5fxr]], [[5fxs]], [[5hzn]] - hIGFR I kinase domain + inhibitor<BR />
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**[[5u8r]] - hIGFR I (mutant) + antibody<BR />
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==IGFR II==
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**[[5u8q]] - hIGFR I (mutant) + IGFI + antibody<BR />
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**[[6pyh]] - hIGFR I + IGFI – Cryo EM<BR />
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[[1gqb]] - hIGFR II<BR />
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**[[6vwg]], [[6vwh]], [[6vwi]], [[6vwj]] - hIGFR I + IGFII – Cryo EM<BR />
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[[2kva]] - hIGFR II domain 5 – NMR<BR />
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**[[7s8v]] - hIGFR I + insulin receptor – Cryo EM<BR />
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[[2cnj]] - hIGFR II domain 11 - NMR<BR />
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**[[7s0q]] - hIGFR I + insulin receptor + IGF I – Cryo EM<BR />
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[[2l2a]] - hIGFR II domains 11 (mutant) - NMR<BR />
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[[2kvb]] - hIGFR II domain 5 + inhibitor – NMR<BR />
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[[2v5n]] - hIGFR II domains 11-12<BR />
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[[2v5o]] - hIGFR II domains 11-14<BR />
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[[2v5p]] - hIGFR II domains 11-13 + IGF II<BR />
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[[2l29]] - hIGFR II domain 11 + IGF II - NMR<BR />
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[[1gp0]], [[1gp3]], [[1e6f]] - hIGFR II IGF II-binding domain<br />
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[[1q25]] - bIGFR II domains 1-3 – bovine<BR />
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[[1syo]], [[1sz0]] - bIGFR II domains 1-3 + mannose-6-phosphate<BR />
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*IGFR II
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**[[1gqb]] - hIGFR II<BR />
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**[[2kva]] - hIGFR II domain 5 – NMR<BR />
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**[[2cnj]] - hIGFR II domain 11 - NMR<BR />
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**[[2l2a]], [[2m68]], [[2m6t]] - hIGFR II domains 11 (mutant) - NMR<BR />
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**[[2kvb]] - hIGFR II domain 5 + inhibitor – NMR<BR />
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**[[2v5n]] - hIGFR II domains 11-12<BR />
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**[[2v5o]] - hIGFR II domains 11-14<BR />
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**[[2v5p]] - hIGFR II domains 11-13 + IGF II<BR />
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**[[2l29]] - hIGFR II domain 11 + IGF II - NMR<BR />
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**[[1gp0]], [[1gp3]], [[1e6f]] - hIGFR II IGF II-binding domain<br />
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**[[1q25]] - bIGFR II domains 1-3 – bovine<BR />
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**[[1syo]], [[1sz0]] - bIGFR II domains 1-3 + mannose-6-phosphate<BR />
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**[[2lla]] - IGFR II domain 11 – short-beaked echidna - NMR<BR />
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**[[2l2g]] - IGFR II domain 11 – opossum - NMR<BR />
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}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human insulin-like growth factor 1 receptor complex with inhibitor (PDB code 3i81)

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3D structures of insulin-like growth factor receptor

Updated on 08-June-2023

References

  1. ↑ Hung IC, Chang SS, Chang PC, Lee CC, Chen CY. Memory enhancement by traditional Chinese medicine? J Biomol Struct Dyn. 2012 Dec 19. PMID:23249175 doi:10.1080/07391102.2012.741052

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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