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Janus kinase 3D structures
From Proteopedia
(Difference between revisions)
(New page: == 3D Structures of Janus kinase == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *JAK1 kinase or JH1 domain resi...) |
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| - | *JAK1 | + | *'''JAK1''' |
| - | **[[4e4l]], [[4e4n]], [[4e5w]], [[4ehz]], [[4ei4]], [[4fk6]], [[4i5c]], [[4k6z]], [[3eyg]], [[3eyh]], [[5e1e]], [[5hx8]], [[5khx]], [[6n77]], [[6n78]], [[6n79]], [[6n7a]], [[6n7b]], [[6n7c]], [[6n7d]], [[6elr]], [[6dbn]], [[4k77]], [[6bbu]], [[5wo4]] - hJAK1 kinase domain + PTyr + inhibitor - human<br /> | + | *''JAK1 kinase or JH1 domain residues 869-1153'' |
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| + | **[[4e4l]], [[4e4n]], [[4e5w]], [[4ehz]], [[4ei4]], [[4fk6]], [[4i5c]], [[4k6z]], [[3eyg]], [[3eyh]], [[5e1e]], [[5hx8]], [[5khx]], [[6n77]], [[6n78]], [[6n79]], [[6n7a]], [[6n7b]], [[6n7c]], [[6n7d]], [[6elr]], [[6dbn]], [[4k77]], [[6bbu]], [[5wo4]], [[6w8l]], [[6hzu]], [[6rsb]], [[6rsc]], [[6rsd]], [[6rse]], [[6rsh]], [[6sm8]], [[6smb]], [[6tpe]], [[6tpf]], [[6vnb]], [[6vnc]], [[6vne]], [[6vnf]], [[6vng]], [[6vnh]], [[6vni]], [[6vnj]], [[6vnk]], [[6vnl]], [[6vnm]], [[6vs3]], [[6vsn]], [[6wtq]] - hJAK1 kinase domain + PTyr + inhibitor - human<br /> | ||
**[[5khw]] – hJAK1 kinase domain + PTyr + ADP<br /> | **[[5khw]] – hJAK1 kinase domain + PTyr + ADP<br /> | ||
**[[6c7y]]]] – hJAK1 kinase domain + PTyr + SOCY1 + ADP<br /> | **[[6c7y]]]] – hJAK1 kinase domain + PTyr + SOCY1 + ADP<br /> | ||
| - | **[[6aah]] – hJAK1 kinase domain + PTyr + drug <br /> | + | **[[6aah]], [[6aaj]], [[6vgl]], [[6vn8]], [[6wtn]], [[6wto]] – hJAK1 kinase domain + PTyr + drug <br /> |
| - | *JAK1 pseudokinase domain residues 561-860 | + | *''JAK1 pseudokinase domain residues 561-860'' |
**[[4l00]] – hJAK1 pseudokinase domain <br /> | **[[4l00]] – hJAK1 pseudokinase domain <br /> | ||
**[[4l01]] – hJAK1 pseudokinase domain (mutant)<br /> | **[[4l01]] – hJAK1 pseudokinase domain (mutant)<br /> | ||
| - | *JAK1 FERM-SH2 domain residues 36-514 | + | *''JAK1 FERM-SH2 domain residues 36-514'' |
**[[5ixd]], [[5l04]] – hJAK1 + IFN l receptor <br /> | **[[5ixd]], [[5l04]] – hJAK1 + IFN l receptor <br /> | ||
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**[[6e2q]] – hJAK1 + erythropoietin receptor <br /> | **[[6e2q]] – hJAK1 + erythropoietin receptor <br /> | ||
| - | *JAK2 kinase domain residues 536-812 | + | *'''JAK2''' |
| + | |||
| + | *''JAK2 kinase domain residues 536-812'' | ||
**[[4fvp]] - hJAK2 kinase domain <br /> | **[[4fvp]] - hJAK2 kinase domain <br /> | ||
| + | **[[3ugc]], [[4bbe]], [[4bbf]], [[3zmm]], [[2xa4]], [[4c61]], [[4c62]], [[5l3a]], [[5tq3]], [[5tq4]], [[5tq5]], [[5tq6]], [[5tq7]], [[5tq8]], [[6tpd]] – hJAK2 kinase domain (mutant) + inhibitor <br /> | ||
| + | **[[3e62]], [[3e63]], [[3e64]], [[2w1i]], [[4ytc]], [[4ytf]], [[4yth]], [[4yti]], [[4zim]], [[5aep]], [[5cf4]], [[5cf5]], [[5cf6]], [[3io7]], [[3iok]], [[3kck]], [[3jy9]], [[3lpb]], [[3krr]], [[3q32]], [[3tjc]], [[3tjd]], [[3rvg]], [[4aqc]], [[4e4m]], [[4f09]], [[4hge]], [[4d0w]], [[4d0x]], [[4d1s]], [[4p7e]], [[4aep]], [[5cf8]], [[6ggh]], [[7ree]] – hJAK2 kinase domain + PTyr + inhibitor <br /> | ||
**[[2b7a]], [[3fup]], [[4e6d]], [[4e6q]], [[4f08]] – hJAK2 kinase domain (mutant) + PTyr + inhibitor <br /> | **[[2b7a]], [[3fup]], [[4e6d]], [[4e6q]], [[4f08]] – hJAK2 kinase domain (mutant) + PTyr + inhibitor <br /> | ||
| - | **[[3ugc]], [[4bbe]], [[4bbf]], [[3zmm]], [[2xa4]], [[4c61]], [[4c62]], [[5l3a]], [[5tq3]], [[5tq4]], [[5tq5]], [[5tq6]], [[5tq7]], [[5tq8]] – hJAK2 kinase domain (mutant) + inhibitor <br /> | ||
| - | **[[3e62]], [[3e63]], [[3e64]], [[2w1i]], [[4ytc]], [[4ytf]], [[4yth]], [[4yti]], [[4zim]], [[5aep]], [[5cf4]], [[5cf5]], [[5cf6]], [[3io7]], [[3iok]], [[3kck]], [[3jy9]], [[3lpb]], [[3krr]], [[3q32]], [[3tjc]], [[3tjd]], [[3rvg]], [[4aqc]], [[4e4m]], [[4f09]], [[4hge]], [[4d0w]], [[4d0x]], [[4d1s]], [[4p7e]], [[4aep]], [[5cf8]] – hJAK2 kinase domain + PTyr + inhibitor <br /> | ||
**[[6aaj]] – hJAK2 kinase domain (mutant) + PTyr + drug <br /> | **[[6aaj]] – hJAK2 kinase domain (mutant) + PTyr + drug <br /> | ||
**[[4gl9]] – mJAK2 kinase domain + PTyr + inhibitor + suppressor of cytokine signaling 3 + interleukin 6 receptor subunit β - mouse<br /> | **[[4gl9]] – mJAK2 kinase domain + PTyr + inhibitor + suppressor of cytokine signaling 3 + interleukin 6 receptor subunit β - mouse<br /> | ||
| - | *JAK2 JH1 domain residues 833-1132 | + | *''JAK2 JH1 domain residues 833-1132'' |
**[[4gfm]], [[4gmy]], [[4iva]], [[4ivb]], [[4ivc]], [[4ivd]], [[4ji9]], [[4jia]], [[5usy]], [[5usz]], [[5ut0]], [[5ut1]], [[5ut2]], [[5ut3]], [[5ut4]], [[5ut5]], [[5ut6]], [[6drw]], [[5wev]] - hJAK2 JH1 domain + PTyr + inhibitor <br /> | **[[4gfm]], [[4gmy]], [[4iva]], [[4ivb]], [[4ivc]], [[4ivd]], [[4ji9]], [[4jia]], [[5usy]], [[5usz]], [[5ut0]], [[5ut1]], [[5ut2]], [[5ut3]], [[5ut4]], [[5ut5]], [[5ut6]], [[6drw]], [[5wev]] - hJAK2 JH1 domain + PTyr + inhibitor <br /> | ||
**[[5hez]] - hJAK2 JH1 domain (mutant) + PTyr + inhibitor <br /> | **[[5hez]] - hJAK2 JH1 domain (mutant) + PTyr + inhibitor <br /> | ||
| - | **[[6bbv]] - hJAK2 JH1 domain + inhibitor <br /> | + | **[[6bbv]], [[6wtp]], [[7ll4]], [[7ll5]], [[7q7i]], [[7q7k]], [[7q7l]], [[7q7w]], [[7rn6]], [[7uyw]] - hJAK2 JH1 domain + inhibitor <br /> |
| - | *JAK2 JH2 or pseudokinase domain residues 536-812 | + | *''JAK2 JH2 or pseudokinase domain residues 536-812'' |
| - | **[[6brw]], [[6d2i]], [[6bs0]], [[6bss]], [[5wij]], [[5wik]], [[5wil]], [[5wim]] - hJAK2 JH2 domain (mutant) + inhibitor <br /> | + | **[[7f7w]] – hJAK2 JH2 domain <br /> |
| + | **[[6obb]], [[7t0p]] - hJAK2 JH2 domain + inhibitor <br /> | ||
| + | **[[6brw]], [[6d2i]], [[6bs0]], [[6bss]], [[5wij]], [[5wik]], [[5wil]], [[5wim]], [[5win]], [[6g3c]], [[6m9h]], [[6oav]], [[6obf]], [[6obl]], [[6occ]], [[6x8e]], [[6xjk]], [[7jyo]], [[7jyq]], [[7t1t]], [[8b8n]], [[8b8u]], [[8b99]], [[8b9e]], [[8b9h]], [[8ba2]], [[8bab]], [[8bak]], [[8ex0]], [[8ex1]], [[8ex2]] - hJAK2 JH2 domain (mutant) + inhibitor <br /> | ||
| + | **[[8ba3]], [[8ba4]] - hJAK2 JH2 domain (mutant) + drug<br /> | ||
**[[3ugc]] – hJAK2 JH2 domain (mutant) <br /> | **[[3ugc]] – hJAK2 JH2 domain (mutant) <br /> | ||
**[[4fvq]], [[4fvr]], [[5i4n]] – hJAK2 JH2 domain (mutant) + ATP<br /> | **[[4fvq]], [[4fvr]], [[5i4n]] – hJAK2 JH2 domain (mutant) + ATP<br /> | ||
| - | *JAK2 FERM-SH2 domain residues 31-516 | + | *''JAK2 FERM-SH2 domain residues 31-516'' |
**[[4z32]] – hJAK2 <br /> | **[[4z32]] – hJAK2 <br /> | ||
| - | *JAK3 kinase domain residues 810-1100 | + | *'''JAK3''' |
| + | |||
| + | *''JAK3 kinase domain residues 810-1100'' | ||
**[[1yvj]] – hJAK3 kinase domain (mutant) + PTyr + staurosporine analog<br /> | **[[1yvj]] – hJAK3 kinase domain (mutant) + PTyr + staurosporine analog<br /> | ||
**[[3lxk]], [[3lxl]], [[5wfj]] – hJAK3 kinase domain (mutant) + PTyr + inhibitor <br /> | **[[3lxk]], [[3lxl]], [[5wfj]] – hJAK3 kinase domain (mutant) + PTyr + inhibitor <br /> | ||
| - | **[[3pjc]], [[4v0g]], [[4z16]], [[5lwm]], [[5lwn]], [[5toz]], [[6glb]], [[6gl9]], [[6gla]], [[6ny4]], [[6dud]], [[6da4]] – hJAK3 kinase domain + inhibitor <br /> | + | **[[3pjc]], [[4v0g]], [[4z16]], [[5lwm]], [[5lwn]], [[5toz]], [[6glb]], [[6gl9]], [[6gla]], [[6ny4]], [[6dud]], [[6da4]], [[7apf]], [[7apg]], [[7q6h]], [[7uyv]] – hJAK3 kinase domain + inhibitor <br /> |
| - | **[[4hvd]], [[4hvg]], [[4hvh]], [[4hvi]], [[3zc6]], [[3zep]], [[4i6q]], [[4qps]], [[4rio]], [[4qt1]], [[5tts]], [[5ttu]], [[5ttv]], [[5vo6]] – hJAK3 kinase domain (mutant) + inhibitor <br /> | + | **[[4hvd]], [[4hvg]], [[4hvh]], [[4hvi]], [[3zc6]], [[3zep]], [[4i6q]], [[4qps]], [[4rio]], [[4qt1]], [[5tts]], [[5ttu]], [[5ttv]], [[5vo6]], [[6db3]], [[6db4]] – hJAK3 kinase domain (mutant) + inhibitor <br /> |
| - | **[[5w86]] – hJAK3 kinase domain + PTyr + inhibitor <br /> | + | **[[5w86]], [[6hzv]] – hJAK3 kinase domain + PTyr + inhibitor <br /> |
| + | **[[7c3n]] – hJAK3 kinase domain + PTyr + drug <br /> | ||
**[[6aak]] – hJAK3 kinase domain (mutant) + PTyr + drug <br /> | **[[6aak]] – hJAK3 kinase domain (mutant) + PTyr + drug <br /> | ||
| + | |||
| + | *JAK | ||
| + | |||
| + | **[[7t6f]], [[8ewy]] – mJAK + interferon lambda receptor 1 <br /> | ||
*TYK2 see [[Tyrosine kinase]] | *TYK2 see [[Tyrosine kinase]] | ||
Current revision
3D Structures of Janus kinase
Updated on 12-June-2023
