1l2c

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[[Image:1l2c.gif|left|200px]]
[[Image:1l2c.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1l2c |SIZE=350|CAPTION= <scene name='initialview01'>1l2c</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_1l2c", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=HPD:1-HYDROXY-PENTANE-3,4-DIOL-5-PHOSPHATE'>HPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= mutM ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Geobacillus stearothermophilus])
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-->
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|DOMAIN=
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{{STRUCTURE_1l2c| PDB=1l2c | SCENE= }}
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|RELATEDENTRY=[[1l1t|1L1T]], [[1l1z|1L1Z]], [[1l2b|1L2B]], [[1l2d|1L2D]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1l2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1l2c OCA], [http://www.ebi.ac.uk/pdbsum/1l2c PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1l2c RCSB]</span>
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}}
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'''MutM (Fpg)-DNA Estranged Thymine Mismatch Recognition Complex'''
'''MutM (Fpg)-DNA Estranged Thymine Mismatch Recognition Complex'''
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==About this Structure==
==About this Structure==
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1L2C is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2C OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1L2C OCA].
==Reference==
==Reference==
Structural insights into lesion recognition and repair by the bacterial 8-oxoguanine DNA glycosylase MutM., Fromme JC, Verdine GL, Nat Struct Biol. 2002 Jul;9(7):544-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12055620 12055620]
Structural insights into lesion recognition and repair by the bacterial 8-oxoguanine DNA glycosylase MutM., Fromme JC, Verdine GL, Nat Struct Biol. 2002 Jul;9(7):544-52. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12055620 12055620]
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[[Category: Geobacillus stearothermophilus]]
 
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[[Category: Protein complex]]
 
[[Category: Fromme, J C.]]
[[Category: Fromme, J C.]]
[[Category: Verdine, G L.]]
[[Category: Verdine, G L.]]
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[[Category: dna glycosylase]]
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[[Category: Dna glycosylase]]
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[[Category: dna repair]]
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[[Category: Dna repair]]
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[[Category: zinc finger]]
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[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 23:27:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:56:58 2008''
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Revision as of 20:27, 2 May 2008

Image:1l2c.gif

Template:STRUCTURE 1l2c

MutM (Fpg)-DNA Estranged Thymine Mismatch Recognition Complex


Overview

MutM is a bacterial 8-oxoguanine glycosylase responsible for initiating base-excision repair of oxidized guanine residues in DNA. Here we report five different crystal structures of MutM-DNA complexes that represent different steps of the repair reaction cascade catalyzed by the protein and also differ in the identity of the base opposite the lesion (the 'estranged' base). These structures reveal that the MutM active site performs the multiple steps of base-excision and 3' and 5' nicking with minimal rearrangement of the DNA backbone.

About this Structure

Full crystallographic information is available from OCA.

Reference

Structural insights into lesion recognition and repair by the bacterial 8-oxoguanine DNA glycosylase MutM., Fromme JC, Verdine GL, Nat Struct Biol. 2002 Jul;9(7):544-52. PMID:12055620 Page seeded by OCA on Fri May 2 23:27:37 2008

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