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8hmf
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8hmf is ON HOLD Authors: Ma, Y., Wu, J., Lei, M. Description: head module state 2 of Tetrahymena IFT-A Category: Unreleased Structures [[Catego...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==head module state 2 of Tetrahymena IFT-A== | |
| + | <StructureSection load='8hmf' size='340' side='right'caption='[[8hmf]], [[Resolution|resolution]] 4.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8hmf]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HMF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HMF FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hmf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hmf OCA], [https://pdbe.org/8hmf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hmf RCSB], [https://www.ebi.ac.uk/pdbsum/8hmf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hmf ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q244W3_TETTS Q244W3_TETTS] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Intraflagellar transport (IFT) trains, the polymers composed of two multi-subunit complexes, IFT-A and IFT-B, carry out bidirectional intracellular transport in cilia, vital for cilia biogenesis and signaling. IFT-A plays crucial roles in the ciliary import of membrane proteins and the retrograde cargo trafficking. However, the molecular architecture of IFT-A and the assembly mechanism of the IFT-A into the IFT trains in vivo remains elusive. Here, we report the cryo-electron microscopic structures of the IFT-A complex from protozoa Tetrahymena thermophila. We find that IFT-A complexes present two distinct, elongated and folded states. Remarkably, comparison with the in situ cryo-electron tomography structure of the anterograde IFT train unveils a series of adjustments of the flexible arms in apo IFT-A when incorporated into the anterograde train. Our results provide an atomic-resolution model for the IFT-A complex and valuable insights into the assembly mechanism of anterograde IFT trains. | ||
| - | + | Structural insight into the intraflagellar transport complex IFT-A and its assembly in the anterograde IFT train.,Ma Y, He J, Li S, Yao D, Huang C, Wu J, Lei M Nat Commun. 2023 Mar 17;14(1):1506. doi: 10.1038/s41467-023-37208-2. PMID:36932088<ref>PMID:36932088</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 8hmf" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: Ma | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Tetrahymena thermophila]] | ||
| + | [[Category: Lei M]] | ||
| + | [[Category: Ma Y]] | ||
| + | [[Category: Wu J]] | ||
Current revision
head module state 2 of Tetrahymena IFT-A
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