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2i1p

From Proteopedia

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(New page: 200px<br /><applet load="2i1p" size="450" color="white" frame="true" align="right" spinBox="true" caption="2i1p" /> '''Solution structure of the twelfth cysteine-r...)
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[[Image:2i1p.jpg|left|200px]]<br /><applet load="2i1p" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2i1p" />
 
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'''Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin'''<br />
 
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==Overview==
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==Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin==
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Megalin, an approx. 600 kDa transmembrane glycoprotein that acts as, multi-ligand transporter, is a member of the low density lipoprotein, receptor gene family. Several cysteine-rich repeats, each consisting of, about 40 residues, are responsible for the multispecific binding of, ligands. The solution structure of the twelfth cysteine-rich, ligand-binding repeat with class A motif found in megalin features two, short beta-strands and two helical turns, yielding the typical fold with a, I-III, II-V and IV-VI disulfide bridge connectivity pattern and a calcium, coordination site at the C-terminal end. The resulting differences in, electrostatic surface potential compared to other ligand-binding modules, of this gene family, however, may be responsible for the functional, divergence.
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<StructureSection load='2i1p' size='340' side='right'caption='[[2i1p]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2i1p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I1P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i1p OCA], [https://pdbe.org/2i1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i1p RCSB], [https://www.ebi.ac.uk/pdbsum/2i1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i1p ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LRP2_RAT LRP2_RAT] Acts together with cubilin to mediate HDL endocytosis (By similarity). Receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B.<ref>PMID:7544804</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i1/2i1p_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i1p ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Megalin, an approx. 600 kDa transmembrane glycoprotein that acts as multi-ligand transporter, is a member of the low density lipoprotein receptor gene family. Several cysteine-rich repeats, each consisting of about 40 residues, are responsible for the multispecific binding of ligands. The solution structure of the twelfth cysteine-rich ligand-binding repeat with class A motif found in megalin features two short beta-strands and two helical turns, yielding the typical fold with a I-III, II-V and IV-VI disulfide bridge connectivity pattern and a calcium coordination site at the C-terminal end. The resulting differences in electrostatic surface potential compared to other ligand-binding modules of this gene family, however, may be responsible for the functional divergence.
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==About this Structure==
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Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin.,Wolf CA, Dancea F, Shi M, Bade-Noskova V, Ruterjans H, Kerjaschki D, Lucke C J Biomol NMR. 2007 Apr;37(4):321-8. Epub 2007 Jan 24. PMID:17245526<ref>PMID:17245526</ref>
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2I1P is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2I1P OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin., Wolf CA, Dancea F, Shi M, Bade-Noskova V, Ruterjans H, Kerjaschki D, Lucke C, J Biomol NMR. 2007 Apr;37(4):321-8. Epub 2007 Jan 24. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17245526 17245526]
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</div>
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<div class="pdbe-citations 2i1p" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Bade-Noskova V]]
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[[Category: Bade-Noskova, V.]]
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[[Category: Dancea F]]
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[[Category: Dancea, F.]]
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[[Category: Kerjaschki D]]
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[[Category: Kerjaschki, D.]]
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[[Category: Luecke C]]
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[[Category: Luecke, C.]]
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[[Category: Rueterjans H]]
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[[Category: Rueterjans, H.]]
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[[Category: Shi M]]
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[[Category: Shi, M.]]
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[[Category: Wolf CA]]
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[[Category: Wolf, C.A.]]
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[[Category: CA]]
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[[Category: calcium cage]]
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[[Category: cysteine-rich repeat]]
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[[Category: ligand binding domain]]
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[[Category: low density lipoprotein receptor]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 12:06:09 2007''
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Current revision

Solution structure of the twelfth cysteine-rich ligand-binding repeat in rat megalin

PDB ID 2i1p

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