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2kuy

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[[Image:2kuy.png|left|200px]]
 
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==Structure of Glycocin F==
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The line below this paragraph, containing "STRUCTURE_2kuy", creates the "Structure Box" on the page.
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<StructureSection load='2kuy' size='340' side='right'caption='[[2kuy]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2kuy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactiplantibacillus_plantarum Lactiplantibacillus plantarum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KUY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KUY FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kuy OCA], [https://pdbe.org/2kuy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kuy RCSB], [https://www.ebi.ac.uk/pdbsum/2kuy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kuy ProSAT]</span></td></tr>
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{{STRUCTURE_2kuy| PDB=2kuy | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GCCF_LACPN GCCF_LACPN] Has antibacterial activity against L.plantarum ATCC 8014. In purified form, the activity is bacteriostatic (IC(50)=2 nM) rather than bactericidal.<ref>PMID:21251913</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bacteriocins are bacterial peptides with specific activity against competing species. They hold great potential as natural preservatives and for their probiotic effects. We show here nuclear magnetic resonance-based evidence that glycocin F, a 43-amino acid bacteriocin from Lactobacillus plantarum, contains two beta-linked N-acetylglucosamine moieties, attached via side chain linkages to a serine via oxygen, and to a cysteine via sulfur. The latter linkage is novel and has helped to establish a new type of post-translational modification, the S-linked sugar. The peptide conformation consists primarily of two alpha-helices held together by a pair of nested disulfide bonds. The serine-linked sugar is positioned on a short loop sequentially connecting the two helices, while the cysteine-linked sugar presents at the end of a long disordered C-terminal tail. The differing chemical and conformational stabilities of the two N-actetylglucosamine moieties provide clues about the possible mode of action of this bacteriostatic peptide.
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===Structure of Glycocin F===
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Structural, dynamic, and chemical characterization of a novel s-glycosylated bacteriocin.,Venugopal H, Edwards PJ, Schwalbe M, Claridge JK, Libich DS, Stepper J, Loo T, Patchett ML, Norris GE, Pascal SM Biochemistry. 2011 Apr 12;50(14):2748-55. Epub 2011 Mar 21. PMID:21395300<ref>PMID:21395300</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_21395300}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2kuy" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 21395300 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21395300}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Lactiplantibacillus plantarum]]
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[[2kuy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lactobacillus_plantarum Lactobacillus plantarum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KUY OCA].
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[[Category: Large Structures]]
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[[Category: Claridge J]]
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==Reference==
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[[Category: Edwards P]]
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<ref group="xtra">PMID:021395300</ref><references group="xtra"/>
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[[Category: Libich D]]
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[[Category: Lactobacillus plantarum]]
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[[Category: Loo T]]
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[[Category: Claridge, J.]]
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[[Category: Norris G]]
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[[Category: Edwards, P.]]
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[[Category: Pascal S]]
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[[Category: Libich, D.]]
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[[Category: Patchett M]]
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[[Category: Loo, T.]]
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[[Category: Schwalbe M]]
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[[Category: Norris, G.]]
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[[Category: Stepper J]]
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[[Category: Pascal, S.]]
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[[Category: Venugopal H]]
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[[Category: Patchett, M.]]
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[[Category: Schwalbe, M.]]
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[[Category: Stepper, J.]]
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[[Category: Venugopal, H.]]
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Current revision

Structure of Glycocin F

PDB ID 2kuy

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