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2l29

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==Complex structure of E4 mutant human IGF2R domain 11 bound to IGF-II==
==Complex structure of E4 mutant human IGF2R domain 11 bound to IGF-II==
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<StructureSection load='2l29' size='340' side='right' caption='[[2l29]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2l29' size='340' side='right'caption='[[2l29]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2l29]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L29 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2L29 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2l29]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L29 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2cnj|2cnj]], [[1gp0|1gp0]], [[2l21|2l21]], [[2l2a|2l2a]]</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l29 OCA], [https://pdbe.org/2l29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l29 RCSB], [https://www.ebi.ac.uk/pdbsum/2l29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l29 ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IGF2, PP1446 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2l29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l29 OCA], [http://pdbe.org/2l29 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2l29 RCSB], [http://www.ebi.ac.uk/pdbsum/2l29 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2l29 ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/IGF2_HUMAN IGF2_HUMAN]] Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SRS) [MIM:[http://omim.org/entry/180860 180860]]. A clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age.<ref>PMID:19066168</ref>
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[https://www.uniprot.org/uniprot/IGF2_HUMAN IGF2_HUMAN] Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SRS) [MIM:[https://omim.org/entry/180860 180860]. A clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age.<ref>PMID:19066168</ref>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IGF2_HUMAN IGF2_HUMAN]] The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.<ref>PMID:16912056</ref> Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.<ref>PMID:16912056</ref>
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[https://www.uniprot.org/uniprot/IGF2_HUMAN IGF2_HUMAN] The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.<ref>PMID:16912056</ref> Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.<ref>PMID:16912056</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Crump, M P]]
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[[Category: Large Structures]]
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[[Category: Ellis, R Z]]
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[[Category: Crump MP]]
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[[Category: Forbes, B]]
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[[Category: Ellis RZ]]
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[[Category: Frago, S]]
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[[Category: Forbes B]]
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[[Category: Hassan, A B]]
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[[Category: Frago S]]
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[[Category: Hoppe, H]]
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[[Category: Hassan AB]]
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[[Category: Jones, E Y]]
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[[Category: Hoppe H]]
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[[Category: Prince, S N]]
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[[Category: Jones EY]]
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[[Category: Rezgui, D]]
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[[Category: Prince SN]]
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[[Category: Strickland, M]]
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[[Category: Rezgui D]]
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[[Category: Wattana-Amorn, P]]
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[[Category: Strickland M]]
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[[Category: Williams, C]]
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[[Category: Wattana-Amorn P]]
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[[Category: Zaccheo, O J]]
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[[Category: Williams C]]
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[[Category: Genomic imprinting]]
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[[Category: Zaccheo OJ]]
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[[Category: Insulin-like growth factor 2]]
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[[Category: Ligand trap]]
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[[Category: Mannose 6 phosphate receptor]]
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[[Category: Transport protein]]
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Current revision

Complex structure of E4 mutant human IGF2R domain 11 bound to IGF-II

PDB ID 2l29

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