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2ll5
From Proteopedia
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| - | [[Image:2ll5.jpg|left|200px]] | ||
| - | + | ==Cyclo-TC1 Trp-cage== | |
| + | <StructureSection load='2ll5' size='340' side='right'caption='[[2ll5]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2ll5]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LL5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LL5 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ll5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ll5 OCA], [https://pdbe.org/2ll5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ll5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ll5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ll5 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | To provide high-resolution X-ray crystallographic structures of a peptide with the Trp-cage fold, we prepared a cyclized version of this motif. Cyclized Trp-cage is remarkably stable and afforded two crystal forms suitable for X-ray diffraction. The resulting higher resolution crystal structures validate the prior NMR models and provide explanations for experimental observations that could not be rationalized by NMR structural data, including the structural basis for the increase in fold stability associated with motif cyclization and the manner in which a polar serine side chain is accommodated in the hydrophobic interior. A hexameric oligomer of the cyclic peptide is found in both crystal forms and indicates that under appropriate conditions, this minimized system may also serve as a model for protein-protein interactions. | ||
| - | + | Crystal and NMR structures of a Trp-cage mini-protein benchmark for computational fold prediction.,Scian M, Lin JC, Le Trong I, Makhatadze GI, Stenkamp RE, Andersen NH Proc Natl Acad Sci U S A. 2012 Jul 16. PMID:22802678<ref>PMID:22802678</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 2ll5" style="background-color:#fffaf0;"></div> | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Andersen NH]] |
| - | [[Category: | + | [[Category: Lin JC]] |
| - | + | [[Category: Scian M]] | |
Current revision
Cyclo-TC1 Trp-cage
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