This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2m0q

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
==Solution NMR analysis of intact KCNE2 in detergent micelles demonstrate a straight transmembrane helix==
==Solution NMR analysis of intact KCNE2 in detergent micelles demonstrate a straight transmembrane helix==
-
<StructureSection load='2m0q' size='340' side='right'caption='[[2m0q]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+
<StructureSection load='2m0q' size='340' side='right'caption='[[2m0q]]' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[2m0q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M0Q FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[2m0q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M0Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M0Q FirstGlance]. <br>
-
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">KCNE2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m0q OCA], [https://pdbe.org/2m0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m0q RCSB], [https://www.ebi.ac.uk/pdbsum/2m0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m0q ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m0q OCA], [https://pdbe.org/2m0q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m0q RCSB], [https://www.ebi.ac.uk/pdbsum/2m0q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m0q ProSAT]</span></td></tr>
+
</table>
</table>
== Disease ==
== Disease ==
-
[[https://www.uniprot.org/uniprot/KCNE2_HUMAN KCNE2_HUMAN]] Familial atrial fibrillation;Romano-Ward syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
+
[https://www.uniprot.org/uniprot/KCNE2_HUMAN KCNE2_HUMAN] Familial atrial fibrillation;Romano-Ward syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/KCNE2_HUMAN KCNE2_HUMAN]] Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current.
+
[https://www.uniprot.org/uniprot/KCNE2_HUMAN KCNE2_HUMAN] Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 24: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Chen, L]]
+
[[Category: Chen L]]
-
[[Category: Lai, C]]
+
[[Category: Lai C]]
-
[[Category: Li, P]]
+
[[Category: Li P]]
-
[[Category: Tian, C]]
+
[[Category: Tian C]]
-
[[Category: Wu, F]]
+
[[Category: Wu F]]
-
[[Category: Zhang, L]]
+
[[Category: Zhang L]]
-
[[Category: Detergent micelle]]
+
-
[[Category: Membrane protein]]
+
-
[[Category: Transmembrane helix]]
+

Revision as of 09:23, 14 June 2023

Solution NMR analysis of intact KCNE2 in detergent micelles demonstrate a straight transmembrane helix

PDB ID 2m0q

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2m0q"
Personal tools