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2mcr

From Proteopedia

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Current revision

Solution structure of ShK-like immunomodulatory peptide from Brugia malayi (filarial worm)

Structural highlights

2mcr is a 1 chain structure with sequence from Brugia malayi. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

A0A0J9XQE3_BRUMA Metalloprotease.[ARBA:ARBA00002657]

Publication Abstract from PubMed

The voltage-gated potassium (Kv) 1.3 channel is widely regarded as a therapeutic target for immunomodulation in autoimmune diseases. ShK-186, a selective inhibitor of Kv1.3 channels, ameliorates autoimmune diseases in rodent models, and human phase 1 trials of this agent in healthy volunteers have been completed. In this study, we identified and characterized a large family of Stichodactyla helianthus toxin (ShK)-related peptides in parasitic worms. Based on phylogenetic analysis, 2 worm peptides were selected for study: AcK1, a 51-residue peptide expressed in the anterior secretory glands of the dog-infecting hookworm Ancylostoma caninum and the human-infecting hookworm Ancylostoma ceylanicum, and BmK1, the C-terminal domain of a metalloprotease from the filarial worm Brugia malayi. These peptides in solution adopt helical structures closely resembling that of ShK. At doses in the nanomolar-micromolar range, they block native Kv1.3 in human T cells and cloned Kv1.3 stably expressed in L929 mouse fibroblasts. They preferentially suppress the proliferation of rat CCR7- effector memory T cells without affecting naive and central memory subsets and inhibit the delayed-type hypersensitivity (DTH) response caused by skin-homing effector memory T cells in rats. Further, they suppress IFNgamma production by human T lymphocytes. ShK-related peptides in parasitic worms may contribute to the potential beneficial effects of probiotic parasitic worm therapy in human autoimmune diseases.-Chhabra, S., Chang, S. C., Nguyen, H. M., Huq, R., Tanner, M. R., Londono, L. M., Estrada, R., Dhawan, V., Chauhan, S., Upadhyay, S. K., Gindin, M., Hotez, P. J., Valenzuela, J. G., Mohanty, B., Swarbrick, J. D., Wulff, H., Iadonato, S. P., Gutman, G. A., Beeton, C., Pennington, M. W., Norton, R. S., Chandy, K. G. Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases.

Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases.,Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK, Gindin M, Hotez PJ, Valenzuela JG, Mohanty B, Swarbrick JD, Wulff H, Iadonato SP, Gutman GA, Beeton C, Pennington MW, Norton RS, Chandy KG FASEB J. 2014 Jun 2. pii: fj.14-251967. PMID:24891519^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Chhabra S, Chang SC, Nguyen HM, Huq R, Tanner MR, Londono LM, Estrada R, Dhawan V, Chauhan S, Upadhyay SK, Gindin M, Hotez PJ, Valenzuela JG, Mohanty B, Swarbrick JD, Wulff H, Iadonato SP, Gutman GA, Beeton C, Pennington MW, Norton RS, Chandy KG. Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: implications for autoimmune diseases. FASEB J. 2014 Jun 2. pii: fj.14-251967. PMID:24891519 doi:http://dx.doi.org/10.1096/fj.14-251967

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2mcr"

@@ Line 1: / Line 1: @@
 ==Solution structure of ShK-like immunomodulatory peptide from Brugia malayi (filarial worm)==
-<StructureSection load='2mcr' size='340' side='right' caption='[[2mcr]], [[NMR_Ensembles_of_Models | 30 NMR models]]' scene=''>
+<StructureSection load='2mcr' size='340' side='right'caption='[[2mcr]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2mcr]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2MCR FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2mcr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Brugia_malayi Brugia malayi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MCR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MCR FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1roo|1roo]], [[2k72|2k72]]</td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2mcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mcr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2mcr RCSB], [http://www.ebi.ac.uk/pdbsum/2mcr PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mcr OCA], [https://pdbe.org/2mcr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mcr RCSB], [https://www.ebi.ac.uk/pdbsum/2mcr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mcr ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A0J9XQE3_BRUMA A0A0J9XQE3_BRUMA] Metalloprotease.[ARBA:ARBA00002657]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 14: / Line 17: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 2mcr" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Chang, S C]]
+[[Category: Brugia malayi]]
-[[Category: Chhabra, S]]
+[[Category: Large Structures]]
-[[Category: Norton, R S]]
+[[Category: Chang SC]]
-[[Category: Pennington, M W]]
+[[Category: Chhabra S]]
-[[Category: Swarbrick, J D]]
+[[Category: Norton RS]]
-[[Category: Bmk1]]
+[[Category: Pennington MW]]
-[[Category: Immune system]]
+[[Category: Swarbrick JD]]
-[[Category: Kv1 3]]
-[[Category: Shk-like peptide]]
-[[Category: Worm]]

2mcr

From Proteopedia

Current revision

Solution structure of ShK-like immunomodulatory peptide from Brugia malayi (filarial worm)

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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