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2n17

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NMR structure of a Kazal-type serine protease inhibitor from the subterranean termite defense gland of Coptotermes formosanus Shiraki soldiers

Structural highlights

2n17 is a 1 chain structure with sequence from Coptotermes formosanus. This structure supersedes the now removed PDB entry 2m25. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

V9GZ93_COPFO

Publication Abstract from PubMed

Coptotermes formosanus is an imported, subterranean termite species with the largest economic impact in the United States. The frontal glands of the soldier caste termites comprising one third of the body mass, contain a secretion expelled through a foramen in defense. The small molecule composition of the frontal gland secretion is well-characterized, but the proteins remain to be identified. Herein is reported the structure and function of one of several proteins found in the termite defense gland secretion. TFP4 is a 6.9 kDa, non-classical group 1 Kazal-type serine protease inhibitor with activity towards chymotrypsin and elastase, but not trypsin. The 3-dimensional solution structure of TFP4 was solved with nuclear magnetic resonance spectroscopy, and represents the first structure from the taxonomic family, Rhinotermitidae. Based on the structure of TFP4, the protease inhibitor active loop (Cys8 to Cys16) was identified.

A Kazal-Type Serine Protease Inhibitor from the Defense Gland Secretion of the Subterranean Termite Coptotermes formosanus Shiraki.,Negulescu H, Guo Y, Garner TP, Goodwin OY, Henderson G, Laine RA, Macnaughtan MA PLoS One. 2015 May 15;10(5):e0125376. doi: 10.1371/journal.pone.0125376., eCollection 2015. PMID:25978745^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Negulescu H, Guo Y, Garner TP, Goodwin OY, Henderson G, Laine RA, Macnaughtan MA. A Kazal-Type Serine Protease Inhibitor from the Defense Gland Secretion of the Subterranean Termite Coptotermes formosanus Shiraki. PLoS One. 2015 May 15;10(5):e0125376. doi: 10.1371/journal.pone.0125376., eCollection 2015. PMID:25978745 doi:http://dx.doi.org/10.1371/journal.pone.0125376

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2n17"

@@ Line 1: / Line 1: @@
 ==NMR structure of a Kazal-type serine protease inhibitor from the subterranean termite defense gland of Coptotermes formosanus Shiraki soldiers==
-<StructureSection load='2n17' size='340' side='right'caption='[[2n17]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+<StructureSection load='2n17' size='340' side='right'caption='[[2n17]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2n17]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Copfo Copfo]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2m25 2m25]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N17 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2n17]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Coptotermes_formosanus Coptotermes formosanus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2m25 2m25]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N17 FirstGlance]. <br>
 </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n17 OCA], [https://pdbe.org/2n17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n17 RCSB], [https://www.ebi.ac.uk/pdbsum/2n17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n17 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/V9GZ93_COPFO V9GZ93_COPFO]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 19: / Line 21: @@
 __TOC__
 </StructureSection>
-[[Category: Copfo]]
+[[Category: Coptotermes formosanus]]
 [[Category: Large Structures]]
-[[Category: Garner, T P]]
+[[Category: Garner TP]]
-[[Category: Goodwin, O Y]]
+[[Category: Goodwin OY]]
-[[Category: Guo, Y]]
+[[Category: Guo Y]]
-[[Category: Henderson, G]]
+[[Category: Henderson G]]
-[[Category: Laine, R A]]
+[[Category: Laine RA]]
-[[Category: Macnaughtan, M A]]
+[[Category: Macnaughtan MA]]
-[[Category: Negulescu, H]]
+[[Category: Negulescu H]]
-[[Category: Chymotrypsin]]
-[[Category: Defense gland]]
-[[Category: Elastase]]
-[[Category: Hydrolase]]
-[[Category: Kazal-type]]
-[[Category: Secretion]]
-[[Category: Serine protease inhibitor]]
-[[Category: Soldier]]
-[[Category: Termite]]

2n17

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Current revision

NMR structure of a Kazal-type serine protease inhibitor from the subterranean termite defense gland of Coptotermes formosanus Shiraki soldiers

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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