This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2n9f
From Proteopedia
(Difference between revisions)
m (Protected "2n9f" [edit=sysop:move=sysop]) |
|||
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Glucose as non natural nucleobase== | |
| + | <StructureSection load='2n9f' size='340' side='right'caption='[[2n9f]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2n9f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N9F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N9F FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4JA:(2S)-3-[(6-DEOXY-BETA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYPROPYL+DIHYDROGEN+PHOSPHATE'>4JA</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n9f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n9f OCA], [https://pdbe.org/2n9f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n9f RCSB], [https://www.ebi.ac.uk/pdbsum/2n9f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n9f ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Noncovalent forces rule the interactions between biomolecules. Inspired by a biomolecular interaction found in aminoglycoside-RNA recognition, glucose-nucleobase pairs have been examined. Deoxyoligonucleotides with a 6-deoxyglucose insertion are able to hybridize with their complementary strand, thus exhibiting a preference for purine nucleobases. Although the resulting double helices are less stable than natural ones, they present only minor local distortions. 6-Deoxyglucose stays fully integrated in the double helix and its OH groups form two hydrogen bonds with the opposing guanine. This 6-deoxyglucose-guanine pair closely resembles a purine-pyrimidine geometry. Quantum chemical calculations indicate that glucose-purine pairs are as stable as a natural T-A pair. | ||
| - | + | Glucose-Nucleobase Pseudo Base Pairs: Biomolecular Interactions within DNA.,Vengut-Climent E, Gomez-Pinto I, Lucas R, Penalver P, Avino A, Fonseca Guerra C, Bickelhaupt FM, Eritja R, Gonzalez C, Morales JC Angew Chem Int Ed Engl. 2016 Jul 18;55(30):8643-7. doi: 10.1002/anie.201603510., Epub 2016 Jun 22. PMID:27328804<ref>PMID:27328804</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 2n9f" style="background-color:#fffaf0;"></div> |
| - | [[Category: Bickelhaupt | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Gonzalez-Ibanez | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Synthetic construct]] |
| - | [[Category: | + | [[Category: Avino A]] |
| - | [[Category: | + | [[Category: Bickelhaupt M]] |
| - | [[Category: | + | [[Category: Eritja R]] |
| + | [[Category: Fonseca-Guerra C]] | ||
| + | [[Category: Gomez-Pinto I]] | ||
| + | [[Category: Gonzalez-Ibanez C]] | ||
| + | [[Category: Lucas R]] | ||
| + | [[Category: Morales J]] | ||
| + | [[Category: Penalver P]] | ||
| + | [[Category: Vengut-Climent E]] | ||
Current revision
Glucose as non natural nucleobase
| |||||||||||
