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2wcy

From Proteopedia

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==NMR SOLUTION STRUCTURE OF FACTOR I-LIKE MODULES OF COMPLEMENT C7.==
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<StructureSection load='2wcy' size='340' side='right' caption='[[2wcy]], [[NMR_Ensembles_of_Models | 48 NMR models]]' scene=''>
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==NMR solution structure of factor I-like modules of complement C7.==
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<StructureSection load='2wcy' size='340' side='right'caption='[[2wcy]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2wcy]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WCY FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2wcy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WCY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WCY FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wcy OCA], [http://pdbe.org/2wcy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wcy RCSB], [http://www.ebi.ac.uk/pdbsum/2wcy PDBsum]</span></td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wcy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wcy OCA], [https://pdbe.org/2wcy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wcy RCSB], [https://www.ebi.ac.uk/pdbsum/2wcy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wcy ProSAT]</span></td></tr>
</table>
</table>
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{{Large structure}}
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== Disease ==
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[https://www.uniprot.org/uniprot/CO7_HUMAN CO7_HUMAN] Immunodeficiency due to a late component of complement deficiency. Disease susceptibility is associated with variations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/CO7_HUMAN CO7_HUMAN] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/2wcy_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wc/2wcy_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Barlow, P N]]
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[[Category: Large Structures]]
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[[Category: Bramham, J]]
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[[Category: Barlow PN]]
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[[Category: Ogata, R T]]
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[[Category: Bramham J]]
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[[Category: Phelan, M M]]
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[[Category: Ogata RT]]
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[[Category: Soares, D C]]
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[[Category: Phelan MM]]
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[[Category: Thai, C T]]
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[[Category: Soares DC]]
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[[Category: C7]]
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[[Category: Thai CT]]
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[[Category: Complement]]
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[[Category: Complement alternate pathway]]
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[[Category: Complement pathway]]
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[[Category: Cytolysis]]
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[[Category: Disease mutation]]
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[[Category: Disulfide]]
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[[Category: Disulfide bond]]
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[[Category: Egf]]
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[[Category: Egf-like domain]]
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[[Category: Factor i module]]
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[[Category: Fim]]
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[[Category: Fimac]]
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[[Category: Follistatin]]
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[[Category: Foln]]
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[[Category: Glycoprotein]]
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[[Category: Immune response]]
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[[Category: Immune system]]
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[[Category: Innate immunity]]
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[[Category: Kazal]]
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[[Category: Mac]]
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[[Category: Membrane attack complex]]
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[[Category: Secreted]]
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[[Category: Sushi]]
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Current revision

NMR solution structure of factor I-like modules of complement C7.

PDB ID 2wcy

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