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5fzv
From Proteopedia
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==High resolution solution NMR structure of the spider venom peptide U3- scytotoxin-Sth1a== | ==High resolution solution NMR structure of the spider venom peptide U3- scytotoxin-Sth1a== | ||
| - | <StructureSection load='5fzv' size='340' side='right' caption='[[5fzv | + | <StructureSection load='5fzv' size='340' side='right'caption='[[5fzv]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5fzv]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZV OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5fzv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Scytodes_thoracica Scytodes thoracica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FZV FirstGlance]. <br> |
| - | </td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fzv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzv OCA], [https://pdbe.org/5fzv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fzv RCSB], [https://www.ebi.ac.uk/pdbsum/5fzv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fzv ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/U31A_SCYTH U31A_SCYTH] Probable insect neurotoxin with ion channel impairing activity (Probable). Does not show activity on 45 human receptors from 9 families (5-hydroxytryptamine, adrenergic, dopamine, muscarinic, histamine, neurotransmitter, opioid, sigma, and gaba(A) receptors) (PubMed:27227898). In vivo, does not cause paralytic or lethal activity when injected into sheep blowflies (PubMed:27227898). When mixed with U3-SYTX-Sth1h does not cause paralytic or lethal activity when injected into crickets (PubMed:27227898). It is noteworthy that both sheep blowflies and crickets are evolutionarily distant from prey species (PubMed:27227898).<ref>PMID:27227898</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Scytodes thoracica]] |
| - | [[Category: | + | [[Category: Loening NM]] |
| - | + | ||
Current revision
High resolution solution NMR structure of the spider venom peptide U3- scytotoxin-Sth1a
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